March 22, 2013

VIA EDGAR TRANSMISSION

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re: Manning & Napier Fund, Inc. (the “Company”)

File Nos. 2-92633 and 811-04087                                                                                              

Ladies and Gentlemen:

On behalf of the Company, attached for filing pursuant to Rule 497(c) under the Securities Act of 1933, as amended (“the 1933 Act”) are exhibits containing interactive data format risk/return summary information that mirrors the risk/return summary information contained in the Company’s Equity Series Prospectus dated March 1, 2013 filed pursuant to Rule 497(c) under the 1933 Act on March 6, 2013. The purpose of this filing is to submit the data in XBRL format for the Company.

Any questions or comments regarding this filing should be directed to the undersigned at (585) 325-6880.

Very truly yours,

/s/ Amy J. Williams

Amy J. Williams

Director of Fund Documentation