<?xml version="1.0" encoding="US-ASCII" ?>
    <!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 3.4c -->
    <!-- Field: Doc-Info; Name: VendorURI; Value: http://www.novaworks.co -->
    <!-- Field: Doc-Info; Name: Source; Value: EVMFT497_30245.xfr; Date: 2013/03/04T23:22:27 -->
    <!-- Field: Doc-Info; Name: Status; Value: 0x00000000 -->
<xbrli:xbrl xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:dei="http://xbrl.sec.gov/dei/2012-01-31" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:rr="http://xbrl.sec.gov/rr/2012-01-31" xmlns:EVMFT="http://eatonvance.com/20130214">
    <link:schemaRef xlink:href="evmft-20130214.xsd" xlink:type="simple" />
    <xbrli:context id="AsOf2013-02-14">
      <xbrli:entity>
        <xbrli:identifier scheme="http://www.sec.gov/CIK">0000745463</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
        <xbrli:startDate>2013-02-14</xbrli:startDate>
        <xbrli:endDate>2013-02-14</xbrli:endDate>
      </xbrli:period>
    </xbrli:context>
    <xbrli:context id="AsOf2013-02-14_S000032773Member">
      <xbrli:entity>
        <xbrli:identifier scheme="http://www.sec.gov/CIK">0000745463</xbrli:identifier>
        <xbrli:segment>
          <xbrldi:explicitMember dimension="dei:LegalEntityAxis">EVMFT:S000032773Member</xbrldi:explicitMember>
        </xbrli:segment>
      </xbrli:entity>
      <xbrli:period>
        <xbrli:startDate>2013-02-14</xbrli:startDate>
        <xbrli:endDate>2013-02-14</xbrli:endDate>
      </xbrli:period>
    </xbrli:context>
    <xbrli:context id="AsOf2013-02-14_S000032773Member_C000111445Member">
      <xbrli:entity>
        <xbrli:identifier scheme="http://www.sec.gov/CIK">0000745463</xbrli:identifier>
        <xbrli:segment>
          <xbrldi:explicitMember dimension="dei:LegalEntityAxis">EVMFT:S000032773Member</xbrldi:explicitMember>
          <xbrldi:explicitMember dimension="rr:ProspectusShareClassAxis">EVMFT:C000111445Member</xbrldi:explicitMember>
        </xbrli:segment>
      </xbrli:entity>
      <xbrli:period>
        <xbrli:startDate>2013-02-14</xbrli:startDate>
        <xbrli:endDate>2013-02-14</xbrli:endDate>
      </xbrli:period>
    </xbrli:context>
    <xbrli:context id="AsOf2013-02-14_S000032773Member_C000101132Member">
      <xbrli:entity>
        <xbrli:identifier scheme="http://www.sec.gov/CIK">0000745463</xbrli:identifier>
        <xbrli:segment>
          <xbrldi:explicitMember dimension="dei:LegalEntityAxis">EVMFT:S000032773Member</xbrldi:explicitMember>
          <xbrldi:explicitMember dimension="rr:ProspectusShareClassAxis">EVMFT:C000101132Member</xbrldi:explicitMember>
        </xbrli:segment>
      </xbrli:entity>
      <xbrli:period>
        <xbrli:startDate>2013-02-14</xbrli:startDate>
        <xbrli:endDate>2013-02-14</xbrli:endDate>
      </xbrli:period>
    </xbrli:context>
    <xbrli:unit id="USD">
      <xbrli:measure>iso4217:USD</xbrli:measure>
    </xbrli:unit>
    <xbrli:unit id="Ratio">
      <xbrli:measure>xbrli:pure</xbrli:measure>
    </xbrli:unit>
    <dei:DocumentType contextRef="AsOf2013-02-14">Other</dei:DocumentType>
    <dei:DocumentPeriodEndDate contextRef="AsOf2013-02-14">2011-12-31</dei:DocumentPeriodEndDate>
    <dei:EntityRegistrantName contextRef="AsOf2013-02-14">Eaton Vance Mutual Funds Trust</dei:EntityRegistrantName>
    <dei:EntityCentralIndexKey contextRef="AsOf2013-02-14">0000745463</dei:EntityCentralIndexKey>
    <dei:AmendmentFlag contextRef="AsOf2013-02-14">false</dei:AmendmentFlag>
    <dei:DocumentCreationDate contextRef="AsOf2013-02-14">2013-02-14</dei:DocumentCreationDate>
    <dei:DocumentEffectiveDate contextRef="AsOf2013-02-14">2013-02-14</dei:DocumentEffectiveDate>
    <rr:ProspectusDate contextRef="AsOf2013-02-14">2012-05-01</rr:ProspectusDate>
    <EVMFT:SupplementTextBlock contextRef="AsOf2013-02-14_S000032773Member">&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 18.7pt; text-align: center"&gt;EATON VANCE PARAMETRIC STRUCTURED COMMODITY&#13;STRATEGY FUND&lt;br /&gt;&#13;Supplement to Summary Prospectus dated May 1, 2012&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt"&gt;The following amendments to the Summary Prospectus are effective&#13;on March 1, 2013.&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt"&gt;1. &amp;#160;The Summary Prospectus is amended to reflect the&#13;following:&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 22.45pt"&gt;&amp;#149;&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt; text-indent: -1.85pt"&gt;The name of the Fund is changed to&#13;Parametric Commodity Strategy Fund;&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 22.45pt"&gt;&amp;#149;&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt; text-indent: -1.85pt"&gt;Class A and Class I shares of the&#13;Fund are renamed Investor Class and Institutional Class, respectively;&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 22.45pt"&gt;&amp;#149;&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt; text-indent: -1.85pt"&gt;The front-end sales charge payable&#13;upon purchase of Investor Class shares of the Fund is eliminated; and&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 22.45pt"&gt;&amp;#149;&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt; text-indent: -1.85pt"&gt;The minimum initial purchase of Institutional&#13;Class shares of the Fund is changed to $50,000 (waived in certain circumstances).&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt"&gt;2. &amp;#160;The following replaces the &amp;#147;Shareholder Fees&amp;#148;&#13;and &amp;#147;Example&amp;#148; tables under &amp;#147;Fees and Expenses of the Fund&amp;#148;:&lt;/p&gt;&#13;&#13;&lt;table cellspacing="0" cellpadding="0" style="width: 100%; font-size: 9pt"&gt;&#13;&lt;tr&gt;&#13;    &lt;td style="width: 76%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 12%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 12%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="vertical-align: bottom; background-color: #E6E6E6"&gt;&#13;    &lt;td style="border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt"&gt;&lt;font style="font-size: 9pt"&gt;Shareholder Fees (fees paid directly from your investment)&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;Investor Class&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;Institutional Class&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="vertical-align: bottom; background-color: #E6E6E6"&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt"&gt;&lt;font style="font-size: 9pt"&gt;Maximum Sales Charge (Load) (as a percentage of offering price)&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;None&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;None&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="vertical-align: bottom; background-color: #E6E6E6"&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt"&gt;&lt;font style="font-size: 9pt"&gt;Maximum Deferred Sales Charge (Load) (as a percentage of the lower of net asset value at purchase or redemption)&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;None&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;None&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;/table&gt;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0"&gt;&amp;#160;&lt;/p&gt;&#13;&#13;&lt;table cellspacing="0" cellpadding="0" style="width: 100%; font-size: 9pt"&gt;&#13;&lt;tr&gt;&#13;    &lt;td style="width: 36%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 16%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 16%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 16%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 16%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="background-color: #E6E6E6"&gt;&#13;    &lt;td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="vertical-align: bottom; border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;1 Year&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="vertical-align: bottom; border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;3 Years&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="vertical-align: bottom; border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;5 Years&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="vertical-align: bottom; border-bottom: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;10 Years&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="vertical-align: bottom; background-color: #E6E6E6"&gt;&#13;    &lt;td style="border-right: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt"&gt;&lt;font style="font-size: 9pt"&gt;Investor Class shares&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$102&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$718&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$1,360&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$3,087&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="vertical-align: bottom; background-color: #E6E6E6"&gt;&#13;    &lt;td style="border-right: black 1pt solid; padding-top: 2.8pt; padding-bottom: 2.8pt"&gt;&lt;font style="font-size: 9pt"&gt;Institutional Class shares&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$77&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$642&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$1,235&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 2.8pt; padding-bottom: 2.8pt; text-align: center"&gt;&lt;font style="font-size: 9pt"&gt;$2,842&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;/table&gt;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 12.15pt 0 5.6pt"&gt;3. &amp;#160;The following replaces the paragraph under&#13;&amp;#147;Purchase and Sale of Fund Shares&amp;#148;:&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt"&gt;You may purchase, redeem or exchange Fund shares on any&#13;business day, which is any day the New York Stock Exchange is open for business. You may purchase, redeem or exchange Fund shares&#13;either through your financial intermediary or directly from the Fund either by writing to the Fund, P.O. Box 9653, Providence,&#13;RI 02940-9653, or by calling 1-800-260-0761. The minimum initial purchase or exchange into the Fund is $1,000 for Investor Class&#13;and $50,000 for Institutional Class (waived in certain circumstances). There is no minimum for subsequent investments.&lt;/p&gt;&#13;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 5.6pt"&gt;&amp;#160;&lt;/p&gt;&#13;&#13;&lt;table cellspacing="0" cellpadding="0" style="width: 100%; font-size: 9pt"&gt;&#13;&lt;tr&gt;&#13;    &lt;td style="width: 50%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&#13;    &lt;td style="width: 50%; font: 0.5pt Times New Roman, Times, Serif"&gt;&amp;#160;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;tr style="vertical-align: top"&gt;&#13;    &lt;td style="padding-top: 5.6pt; padding-bottom: 5.6pt; font-size: 10pt"&gt;&lt;font style="font-size: 10pt"&gt;February 14, 2013&lt;/font&gt;&lt;/td&gt;&#13;    &lt;td style="padding-top: 5.6pt; padding-bottom: 5.6pt; font-size: 10pt; text-align: right"&gt;&lt;font style="font-size: 10pt"&gt;6623-2/13 &amp;#160;&amp;#160;&amp;#160;&amp;#160;PPASCSPS&lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&#13;&lt;/table&gt;&#13;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 5.6pt"&gt;&amp;#160;&lt;/p&gt;</EVMFT:SupplementTextBlock>
    <rr:MaximumSalesChargeImposedOnPurchasesOverOfferingPrice contextRef="AsOf2013-02-14_S000032773Member_C000111445Member" unitRef="Ratio" decimals="INF">0</rr:MaximumSalesChargeImposedOnPurchasesOverOfferingPrice>
    <rr:MaximumSalesChargeImposedOnPurchasesOverOfferingPrice contextRef="AsOf2013-02-14_S000032773Member_C000101132Member" unitRef="Ratio" decimals="INF">0</rr:MaximumSalesChargeImposedOnPurchasesOverOfferingPrice>
    <rr:MaximumDeferredSalesChargeOverOther contextRef="AsOf2013-02-14_S000032773Member_C000111445Member" unitRef="Ratio" decimals="INF">0</rr:MaximumDeferredSalesChargeOverOther>
    <rr:MaximumDeferredSalesChargeOverOther contextRef="AsOf2013-02-14_S000032773Member_C000101132Member" unitRef="Ratio" decimals="INF">0</rr:MaximumDeferredSalesChargeOverOther>
    <rr:ExpenseExampleYear01 contextRef="AsOf2013-02-14_S000032773Member_C000111445Member" unitRef="USD" decimals="0">102</rr:ExpenseExampleYear01>
    <rr:ExpenseExampleYear01 contextRef="AsOf2013-02-14_S000032773Member_C000101132Member" unitRef="USD" decimals="0">77</rr:ExpenseExampleYear01>
    <rr:ExpenseExampleYear03 contextRef="AsOf2013-02-14_S000032773Member_C000111445Member" unitRef="USD" decimals="0">718</rr:ExpenseExampleYear03>
    <rr:ExpenseExampleYear03 contextRef="AsOf2013-02-14_S000032773Member_C000101132Member" unitRef="USD" decimals="0">642</rr:ExpenseExampleYear03>
    <rr:ExpenseExampleYear05 contextRef="AsOf2013-02-14_S000032773Member_C000111445Member" unitRef="USD" decimals="0">1360</rr:ExpenseExampleYear05>
    <rr:ExpenseExampleYear05 contextRef="AsOf2013-02-14_S000032773Member_C000101132Member" unitRef="USD" decimals="0">1235</rr:ExpenseExampleYear05>
    <rr:ExpenseExampleYear10 contextRef="AsOf2013-02-14_S000032773Member_C000111445Member" unitRef="USD" decimals="0">3087</rr:ExpenseExampleYear10>
    <rr:ExpenseExampleYear10 contextRef="AsOf2013-02-14_S000032773Member_C000101132Member" unitRef="USD" decimals="0">2842</rr:ExpenseExampleYear10>
    <rr:ShareholderFeesTableTextBlock contextRef="AsOf2013-02-14_S000032773Member">&lt;div style="display: none"&gt;~ http://xbrl.sec.gov/rr/role/ShareholderFeesData column period compact * column dei_LegalEntityAxis compact EVMFT_S000032773Member column rr_ProspectusShareClassAxis compact * row primary compact * ~&lt;/div&gt;</rr:ShareholderFeesTableTextBlock>
    <rr:ExpenseExampleWithRedemptionTableTextBlock contextRef="AsOf2013-02-14_S000032773Member">&lt;div style="display: none"&gt;~ http://xbrl.sec.gov/rr/role/ExpenseExample column period compact * column dei_LegalEntityAxis compact EVMFT_S000032773Member column rr_ProspectusShareClassAxis compact * row primary compact * ~&lt;/div&gt;</rr:ExpenseExampleWithRedemptionTableTextBlock>
    <dei:TradingSymbol contextRef="AsOf2013-02-14_S000032773Member_C000111445Member">EAPCX</dei:TradingSymbol>
    <dei:TradingSymbol contextRef="AsOf2013-02-14_S000032773Member_C000101132Member">EIPCX</dei:TradingSymbol>
</xbrli:xbrl>
