<?xml version="1.0" encoding="us-ascii"?>
<!-- EDGAR Online I-Metrix Xcelerate Risk Return XBRL Instance Document, based on XBRL 2.1  http://www.edgar-online.com/ -->
<!-- Created (UTC): 1/16/2013 3:14:36 PM -->
<!-- XBRL File Set ID: b5d58798-6793-4c1b-865c-55c8ebabcb2e -->
<!-- App Version: 3.0.0.183, 5.1.2600.196608, 14.0 -->
<!-- Copyright (c) 2005-2013 EDGAR Online, Inc. All Rights Reserved. -->
<xbrl xmlns="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:ixt="http://www.xbrl.org/2008/inlineXBRL/transformation" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:rr="http://xbrl.sec.gov/rr/2010-02-28" xmlns:dei="http://xbrl.us/dei/2009-01-31" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:ck0000730044="http://www.morganstanley.com/20130114">
  <link:schemaRef xlink:href="ck0000730044-20130114.xsd" xlink:type="simple" />
  <unit id="USD">
    <measure>iso4217:USD</measure>
  </unit>
  <unit id="Ratio">
    <measure>pure</measure>
  </unit>
  <context id="DocumentContext" xmlns="http://www.xbrl.org/2003/instance">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000730044</identifier>
    </entity>
    <period>
      <startDate>2013-01-14</startDate>
      <endDate>2013-01-14</endDate>
    </period>
  </context>
  <context id="S000002426member_C000006469member" xmlns="http://www.xbrl.org/2003/instance">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000730044</identifier>
      <segment>
        <xbrldi:explicitMember dimension="dei:LegalEntityAxis" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">ck0000730044:S000002426Member</xbrldi:explicitMember>
        <xbrldi:explicitMember dimension="rr:ProspectusShareClassAxis" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">ck0000730044:C000006469Member</xbrldi:explicitMember>
      </segment>
    </entity>
    <period>
      <startDate>2013-01-14</startDate>
      <endDate>2013-01-14</endDate>
    </period>
  </context>
  <context id="CTXT_P0001S000002426member_S000002426member" xmlns="http://www.xbrl.org/2003/instance">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000730044</identifier>
      <segment>
        <xbrldi:explicitMember dimension="dei:DocumentInformationDocumentAxis" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">ck0000730044:P0001-S000002426Member</xbrldi:explicitMember>
        <xbrldi:explicitMember dimension="dei:LegalEntityAxis" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">ck0000730044:S000002426Member</xbrldi:explicitMember>
      </segment>
    </entity>
    <period>
      <startDate>2013-01-14</startDate>
      <endDate>2013-01-14</endDate>
    </period>
  </context>
  <dei:DocumentType contextRef="DocumentContext">Other</dei:DocumentType>
  <dei:DocumentPeriodEndDate contextRef="DocumentContext">2013-01-14</dei:DocumentPeriodEndDate>
  <dei:EntityRegistrantName contextRef="DocumentContext">MORGAN STANLEY US GOVERNMENT SECURITIES TRUST</dei:EntityRegistrantName>
  <dei:EntityCentralIndexKey contextRef="DocumentContext">0000730044</dei:EntityCentralIndexKey>
  <dei:AmendmentFlag contextRef="DocumentContext">false</dei:AmendmentFlag>
  <dei:DocumentCreationDate contextRef="DocumentContext">2013-01-14</dei:DocumentCreationDate>
  <dei:DocumentEffectiveDate contextRef="DocumentContext">2013-01-14</dei:DocumentEffectiveDate>
  <rr:ProspectusDate contextRef="DocumentContext">2012-04-30</rr:ProspectusDate>
  <rr:RiskReturnHeading contextRef="CTXT_P0001S000002426member_S000002426member">MORGAN STANLEY U.S. GOVERNMENT SECURITIES TRUST</rr:RiskReturnHeading>
  <ck0000730044:SupplementTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;p class="MsoNormal" style="font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;margin-top:12.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"&gt;&lt;font style=&apos;font-size:40.0pt;font-family:"Arial","sans-serif"&apos;&gt;Morgan Stanley&lt;/font&gt;&lt;/p&gt;  &lt;p class="MsoNormal" style="font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;margin-top:12.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"&gt;&lt;i&gt;&lt;font style=&apos;font-size:9.0pt;font-family:"Arial","sans-serif"&apos;&gt;January 14, 2013&lt;/font&gt;&lt;/i&gt;&lt;/p&gt;  &lt;p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"&gt;&lt;font style=&apos;font-size:14.0pt;font-family:"Arial","sans-serif"&apos;&gt;Supplement&lt;/font&gt;&lt;/p&gt;  &lt;p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"&gt;&lt;font style=&apos;font-family:"Arial","sans-serif"&apos;&gt;SUPPLEMENT DATED JANUARY 14, 2013 TO THE PROSPECTUS OF&lt;br /&gt; MORGAN STANLEY U.S. GOVERNMENT SECURITIES TRUST&lt;br /&gt; Dated April 30, 2012&lt;/font&gt;&lt;/p&gt;  &lt;p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;"&gt;&amp;nbsp;&lt;/p&gt;</ck0000730044:SupplementTextBlock>
  <rr:ShareholderFeesCaption contextRef="CTXT_P0001S000002426member_S000002426member">The following table replaces the &amp;quot;Shareholder Fees&amp;quot; table with respect to Class L shares only in the section of the Prospectus entitled &amp;quot;Fund Summary&#8212;Fees and Expenses&#8212;Shareholder Fees,&amp;quot; effective February 25, 2013:  &amp;nbsp;</rr:ShareholderFeesCaption>
  <rr:OperatingExpensesCaption contextRef="CTXT_P0001S000002426member_S000002426member">Effective February 25, 2013, the 12b-1 fee for the Class L shares of the Fund will be reduced from 0.75% to 0.50%. Accordingly, the following table replaces the &amp;quot;Annual Fund Operating Expenses&amp;quot; table with respect to Class L shares only in the section of the Prospectus entitled &amp;quot;Fund Summary&#8212;Fees and Expenses&#8212;Annual Fund Operating Expenses,&amp;quot; effective February 25, 2013:  &amp;nbsp;</rr:OperatingExpensesCaption>
  <rr:ExpenseExampleHeading contextRef="CTXT_P0001S000002426member_S000002426member">The following tables replace the &amp;quot;Example&amp;quot; tables with respect to Class L shares only in the section of the Prospectus entitled &amp;quot;Fund Summary&#8212;Example:&amp;quot;  &amp;nbsp;</rr:ExpenseExampleHeading>
  <rr:ExpenseExampleByYearCaption contextRef="CTXT_P0001S000002426member_S000002426member">If You SOLD Your Shares:  &amp;nbsp;</rr:ExpenseExampleByYearCaption>
  <rr:ExpenseExampleNoRedemptionByYearCaption contextRef="CTXT_P0001S000002426member_S000002426member">If You HELD Your Shares:  &amp;nbsp;</rr:ExpenseExampleNoRedemptionByYearCaption>
  <rr:ExpenseExampleClosingTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"&gt;&lt;font style=&apos;font-size:10.0pt;font-family:"Arial","sans-serif"&apos;&gt;Additionally, all references elsewhere in the&lt;/font&gt;&lt;font style=&apos;font-size:10.0pt;font-family: "Times New Roman","serif"&apos;&gt; &lt;/font&gt;&lt;i&gt;&lt;font style=&apos;font-size:10.0pt;font-family: "Arial","sans-serif"&apos;&gt;Prospectus&lt;/font&gt;&lt;/i&gt;&lt;font style=&apos;font-size:10.0pt; font-family:"Times New Roman","serif"&apos;&gt; &lt;/font&gt;&lt;font style=&apos;font-size:10.0pt; font-family:"Arial","sans-serif"&apos;&gt;to a 12b-1 fee of 0.75% for Class L shares will be replaced with 0.50%.&lt;/font&gt;&lt;/p&gt;  &lt;p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;"&gt;&amp;nbsp;&lt;/p&gt;</rr:ExpenseExampleClosingTextBlock>
  <ck0000730044:SupplementClosingTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;margin-top:10.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"&gt;&lt;font style=&apos;font-size:10.0pt;font-family:"Arial","sans-serif"&apos;&gt;PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE.&lt;/font&gt;&lt;/p&gt;  &lt;p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:&apos;calibri&apos;,&apos;sans-serif&apos;;"&gt;&amp;nbsp;&lt;/p&gt;</ck0000730044:SupplementClosingTextBlock>
  <dei:TradingSymbol contextRef="S000002426member_C000006469member">USGCX</dei:TradingSymbol>
  <rr:MaximumSalesChargeImposedOnPurchasesOverOfferingPrice contextRef="S000002426member_C000006469member" unitRef="Ratio" decimals="4">0.0000</rr:MaximumSalesChargeImposedOnPurchasesOverOfferingPrice>
  <rr:MaximumDeferredSalesChargeOverOfferingPrice contextRef="S000002426member_C000006469member" unitRef="Ratio" decimals="4">0.0000</rr:MaximumDeferredSalesChargeOverOfferingPrice>
  <rr:ShareholderFeesTableTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;div&gt; &amp;lt;div style="display:none;" &amp;gt;~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002426Member row primary compact * row dei_LegalEntityAxis compact ck0000730044_S000002426Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000730044_S000002426Member ~&amp;lt;/div&amp;gt; &lt;/div&gt;</rr:ShareholderFeesTableTextBlock>
  <rr:ManagementFeesOverAssets contextRef="S000002426member_C000006469member" unitRef="Ratio" decimals="4">0.0042</rr:ManagementFeesOverAssets>
  <rr:DistributionAndService12b1FeesOverAssets contextRef="S000002426member_C000006469member" id="id_footnote_1000" unitRef="Ratio" decimals="4">0.0050</rr:DistributionAndService12b1FeesOverAssets>
  <rr:OtherExpensesOverAssets contextRef="S000002426member_C000006469member" unitRef="Ratio" decimals="4">0.0024</rr:OtherExpensesOverAssets>
  <rr:ExpensesOverAssets contextRef="S000002426member_C000006469member" unitRef="Ratio" decimals="4">0.0116</rr:ExpensesOverAssets>
  <rr:AnnualFundOperatingExpensesTableTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;div&gt; &amp;lt;div style="display:none;" &amp;gt;~ http://www.morganstanley.com/20130114/role/OperatingExpensesData_P0001-S000002426Member row primary compact * row dei_LegalEntityAxis compact ck0000730044_S000002426Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000730044_S000002426Member ~&amp;lt;/div&amp;gt; &lt;/div&gt;</rr:AnnualFundOperatingExpensesTableTextBlock>
  <rr:ExpenseExampleYear01 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">118</rr:ExpenseExampleYear01>
  <rr:ExpenseExampleYear03 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">368</rr:ExpenseExampleYear03>
  <rr:ExpenseExampleYear05 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">638</rr:ExpenseExampleYear05>
  <rr:ExpenseExampleYear10 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">1409</rr:ExpenseExampleYear10>
  <rr:ExpenseExampleWithRedemptionTableTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;div&gt; &amp;lt;div style="display:none;" &amp;gt;~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002426Member row primary compact * row dei_LegalEntityAxis compact ck0000730044_S000002426Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000730044_S000002426Member ~&amp;lt;/div&amp;gt; &lt;/div&gt;</rr:ExpenseExampleWithRedemptionTableTextBlock>
  <rr:ExpenseExampleNoRedemptionYear01 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">118</rr:ExpenseExampleNoRedemptionYear01>
  <rr:ExpenseExampleNoRedemptionYear03 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">368</rr:ExpenseExampleNoRedemptionYear03>
  <rr:ExpenseExampleNoRedemptionYear05 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">638</rr:ExpenseExampleNoRedemptionYear05>
  <rr:ExpenseExampleNoRedemptionYear10 contextRef="S000002426member_C000006469member" unitRef="USD" decimals="0">1409</rr:ExpenseExampleNoRedemptionYear10>
  <rr:ExpenseExampleNoRedemptionTableTextBlock contextRef="CTXT_P0001S000002426member_S000002426member">&lt;div&gt; &amp;lt;div style="display:none;" &amp;gt;~ http://www.morganstanley.com/20130114/role/ExpenseExampleNoRedemption_P0001-S000002426Member row primary compact * row dei_LegalEntityAxis compact ck0000730044_S000002426Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000730044_S000002426Member ~&amp;lt;/div&amp;gt; &lt;/div&gt;</rr:ExpenseExampleNoRedemptionTableTextBlock>
  <link:footnoteLink xlink:type="extended" xlink:role="http://www.xbrl.org/2003/role/link">
    <link:footnote xlink:type="resource" xlink:label="footnote_1000" xlink:role="http://www.xbrl.org/2003/role/footnote" xml:lang="en-US">The Board of Trustees approved an amendment to the Plan of Distribution reducing the distribution and shareholder services (12b-1) fee for the Fund&#8217;s Class L shares from 0.75% to 0.50% of the average daily net assets of such Class, effective February 25, 2013. The Distribution and Service (12b-1) Fees shown in the table above have been restated to reflect such change.</link:footnote>
    <link:loc xlink:type="locator" xlink:href="#id_footnote_1000" xlink:label="DistributionAndService12b1FeesOverAssets_1001" />
    <link:footnoteArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote" xlink:from="DistributionAndService12b1FeesOverAssets_1001" xlink:to="footnote_1000" order="1.0" />
  </link:footnoteLink>
</xbrl>
