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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 J5g3iOclS9Mt53t26FIXkCgZUWnDeEdmfc+Eo6qnDvpPL6g6IFcvnDu8sztYmnaC
 vbzBQBLgfDoU4quORklWQw==

<SEC-DOCUMENT>0001225208-11-005343.txt : 20110210
<SEC-HEADER>0001225208-11-005343.hdr.sgml : 20110210
<ACCEPTANCE-DATETIME>20110210163913
ACCESSION NUMBER:		0001225208-11-005343
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110208
FILED AS OF DATE:		20110210
DATE AS OF CHANGE:		20110210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GATES WILLIAM H III
		CENTRAL INDEX KEY:			0000902012

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-13107
		FILM NUMBER:		11593100

	MAIL ADDRESS:	
		STREET 1:		ONE MICROSOFT WAY
		CITY:			REDMOND
		STATE:			WA
		ZIP:			98052

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AUTONATION, INC.
		CENTRAL INDEX KEY:			0000350698
		STANDARD INDUSTRIAL CLASSIFICATION:	RETAIL-AUTO DEALERS & GASOLINE STATIONS [5500]
		IRS NUMBER:				731105145
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		200 SW 1ST AVE
		STREET 2:		SUITE 1600
		CITY:			FORT LAUDERDALE
		STATE:			FL
		ZIP:			33301
		BUSINESS PHONE:		9547696000

	MAIL ADDRESS:	
		STREET 1:		200 SW 1ST AVE
		STREET 2:		SUITE 1600
		CITY:			FORT LAUDERDALE
		STATE:			FL
		ZIP:			33301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AUTONATION, INC. /FL
		DATE OF NAME CHANGE:	20090827

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AutoNation, Inc. /FL
		DATE OF NAME CHANGE:	20090827

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AUTONATION INC /FL
		DATE OF NAME CHANGE:	19990407

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CASCADE INVESTMENT LLC
		CENTRAL INDEX KEY:			0001052192
		STATE OF INCORPORATION:			WA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-13107
		FILM NUMBER:		11593098

	BUSINESS ADDRESS:	
		STREET 1:		2365 CARILLON POINT
		CITY:			KIRKLAND
		STATE:			WA
		ZIP:			98033
		BUSINESS PHONE:		4258030720

	MAIL ADDRESS:	
		STREET 1:		2365 CARILLON POINT
		CITY:			KIRKLAND
		STATE:			WA
		ZIP:			98033
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2011-02-08</periodOfReport>

    <issuer>
        <issuerCik>0000350698</issuerCik>
        <issuerName>AUTONATION, INC.</issuerName>
        <issuerTradingSymbol>AN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001052192</rptOwnerCik>
            <rptOwnerName>CASCADE INVESTMENT LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2365 CARILLON POINT</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>KIRKLAND</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98033</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>1</isOther>
            <otherText>(See footnote 2)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000902012</rptOwnerCik>
            <rptOwnerName>GATES WILLIAM H III</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE MICROSOFT WAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>REDMOND</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98052</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>1</isOther>
            <otherText>(See footnote 2)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2011-02-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>731914.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>32.1723</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>13753872.0000</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This transaction was executed in multiple trades at prices ranging from $31.70 to $32.38.  The price reported above reflects the weighted average purchase price.  The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.</footnote>
        <footnote id="F2">The reporting person may be deemed to be a member of a Section 13(d) group that beneficially owns more than 10% of the issuer's outstanding Common Stock.  This report shall not be deemed an admission that the reporting person and any other person or persons in fact constitute a &quot;group&quot; for purposes of Section 13(d)(3) of the Securities Exchange Act of 1934, as amended, and the reporting person disclaims that it is the beneficial owner of securities owned by such other person or persons, except to the extent of the reporting person's pecuniary interest, if any, therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Alan Heuberger, Attorney-in-fact for each of Michael Larson, Business Manager for Cascade Investment, L.L.C. and William H. Gates III</signatureName>
        <signatureDate>2011-02-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Alan Heuberger, Attorney-in-fact for William H. Gates III</signatureName>
        <signatureDate>2011-02-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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