EXHIBIT 21

Significant Subsidiaries of WesBanco, Inc.

(As of December 31, 2016)

Subsidiaries	State of Incorporation
WesBanco, Inc.		West Virginia
WesBanco Bank, Inc.		West Virginia
WesBanco Insurance Services, Inc.		West Virginia
WesBanco Title Agency, LLC		Ohio
THF, Inc.		Pennsylvania
WesBanco Asset Management, Inc.		Delaware
CBSI Holdings, Inc		Nevada
CBSI Investments, Inc.		Nevada
CBSI Investment Portfolio Management, LLC		Nevada
WesBanco Community Development Corp.		Ohio
CBSI Development Fund, Inc.		Indiana
AMSCO, Inc.		Pennsylvania
AMS Ventures, LLC		Pennsylvania
Bellevue Park Partners, LP		Pennsylvania
Brandy One, LLC		Pennsylvania
The Links at Deer Run Associates, LLC		Pennsylvania
McCormick Farms, LLC		Pennsylvania
McCormick Place Associates		Pennsylvania
The Vineyards at Brandywine, LP		Pennsylvania
Kentuckiana Real Estate Holdings, LLC		Indiana
Southern Indiana Real Estate Holdings, LLC		Indiana
WesBanco Properties, Inc.		West Virginia
WesBanco Securities, Inc.		Ohio
WesBanco Capital Trust II		Delaware
WesBanco Capital Statutory Trust III		Connecticut
WesBanco Capital Trust IV		Delaware
WesBanco Capital Trust V		Delaware
WesBanco Capital Trust VI		Delaware
Oak Hill Capital Trust 2		Delaware
Oak Hill Capital Trust 3		Delaware
Oak Hill Capital Trust 4		Delaware
Community Bank Shares (IN) Statutory Trust I		Indiana
Community Bank Shares (IN) Statutory Trust II		Indiana
First Federal Statutory Trust II		Kentucky
First Federal Statutory Trust III		Kentucky
CBIN Insurance, Inc.		Nevada