EXHIBIT 21

Significant Subsidiaries of WesBanco, Inc.

(As of December 31, 2015)

Subsidiaries	State of Incorporation
WesBanco, Inc.		West Virginia
WesBanco Bank, Inc.		West Virginia
WesBanco Insurance Services, Inc.		West Virginia
WesBanco Title Agency, LLC		Ohio
THF, Inc.		Pennsylvania
WesBanco Asset Management, Inc.		Delaware
WesBanco Community Development Corp.		Ohio
AMSCO, Inc.		Pennsylvania
AMS Ventures, LLC		Pennsylvania
Bellevue Park Partners, LP		Pennsylvania
Brandy One, LLC		Pennsylvania
The Links at Deer Run Associates, LLC		Pennsylvania
McCormick Farms, LLC		Pennsylvania
McCormick Place Associates		Pennsylvania
The Vineyards at Brandywine, LP		Pennsylvania
WesBanco Properties, Inc.		West Virginia
WesBanco Securities, Inc.		Ohio
WesBanco Capital Trust II		Delaware
WesBanco Capital Statutory Trust III		Connecticut
WesBanco Capital Trust IV		Delaware
WesBanco Capital Trust V		Delaware
WesBanco Capital Trust VI		Delaware
Oak Hill Capital Trust 2		Delaware
Oak Hill Capital Trust 3		Delaware
Oak Hill Capital Trust 4		Delaware