The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106   71,495 12,521 SH   DFND 1,2 12,521 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   938,799 29,984 SH   DFND 1,2 29,984 0 0
AEROVATE THERAPEUTICS INC COM 008064107   1,084,792 47,936 SH   DFND 1,2 47,936 0 0
AFFIMED N V COM N01045108   232,795 372,472 SH   DFND 1,2 372,472 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   5,030,696 263,940 SH   DFND 1,2 263,940 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   624,636 41,950 SH   DFND 1,2 41,950 0 0
ARGENX SE SPONSORED ADR 04016X101   544,015 1,430 SH   DFND 1,2 1,430 0 0
ATHIRA PHARMA INC COM 04746L104   437,400 180,000 SH   DFND 1,2 180,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102   2,168,288 12,022 SH   DFND 1,2 12,022 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   106,904 17,847 SH   DFND 1,2 17,847 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   348,558 3,615 SH   DFND 1,2 3,615 0 0
BIOMEA FUSION INC COM 09077A106   580,800 40,000 SH   DFND 1,2 40,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   1,306,986 1,166,952 SH   DFND 1,2 1,166,952 0 0
CABALETTA BIO INC COM 12674W109   1,070,305 47,150 SH   DFND 1,2 47,150 0 0
CERUS CORP COM 157085101   30,612 14,172 SH   DFND 1,2 14,172 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101   353,441 370,950 SH   DFND 1,2 370,950 0 0
EARGO INC COM NEW 270087208   383,071 147,904 SH   DFND 1,2 147,904 0 0
ENTRADA THERAPEUTICS INC COM 29384C108   740,647 49,082 SH   DFND 1,2 49,082 0 0
EXELIXIS INC COM 30161Q104   1,540,158 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102   5,511,908 859,892 SH   DFND 1,2 859,892 0 0
FIBROGEN INC COM 31572Q808   55,045 62,106 SH   DFND 1,2 62,106 0 0
GALERA THERAPEUTICS INC COM 36338D108   89,163 613,223 SH   DFND 1,2 613,223 0 0
GERON CORP COM 374163103   1,927,591 913,550 SH   DFND 1,2 913,550 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   11,907,880 368,665 SH   DFND 1,2 368,665 0 0
ILLUMINA INC COM 452327109   16,596,851 119,196 SH   DFND 1,2 119,196 0 0
INCYTE CORP COM 45337C102   2,010,661 32,022 SH   DFND 1,2 32,022 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   3,727,393 304,277 SH   DFND 1,2 304,277 0 0
KARUNA THERAPEUTICS INC COM 48576A100   71,432,509 225,688 SH   DFND 1,2 225,688 0 0
KODIAK SCIENCES INC COM 50015M109   59,651 19,622 SH   DFND 1,2 19,622 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   273,491 1,182 SH   DFND 1,2 1,182 0 0
MERUS N V COM N5749R100   3,768,545 137,038 SH   DFND 1,2 137,038 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   2,836,872 96,100 SH   DFND 1,2 96,100 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   5,827,618 518,933 SH   DFND 1,2 518,933 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   2,692,727 274,488 SH   DFND 1,2 274,488 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100   1,638,699 493,584 SH   DFND 1,2 493,584 0 0
REPLIMUNE GROUP INC COM 76029N106   1,557,350 184,739 SH   DFND 1,2 184,739 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   1,842,018 40,070 SH   DFND 1,2 40,070 0 0
SOMALOGIC INC CLASS A COM 83444K105   4,292,292 1,696,558 SH   DFND 1,2 1,696,558 0 0
XENON PHARMACEUTICALS INC COM 98420N105   4,913,681 106,680 SH   DFND 1,2 106,680 0 0