EX-FILING FEES

Exhibit 107

Calculation of Filing Fee Tables

Form S-1

(Form Type)

OnKure Therapeutics, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

Security
Type

Security

Class

Title

Fee

Calculation

or Carry

Forward

Rule

Amount

Registered (1)

Proposed

Maximum

Offering

Price Per

Unit (2)

Maximum

Aggregate

Offering

Price

Fee

Rate

Amount of

Registration

Fee

Carry
Forward
Form
Type

Carry
Forward

File
Number

Carry
Forward
Initial
Effective
Date

Filing Fee
Previously
Paid In
Connection
with
Unsold
Securities
to be
Carried
Forward

Equity

Class A Common Stock, $0.0001

par value

per share

457(c)

2,839,005⁽²⁾

$17.66⁽³⁾

$50,136,828.30

$153.10 per $1,000,000

$7,675.95

Total Offering Amounts

$50,136,828.30

$7,675.95

Total Fees Previously Paid

—

Total Fee Offsets

—

Net Fee Due

$7,675.95

(1)

Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of the registrant’s Class A common stock (“Class A Common Stock”) that become issuable as a result of any stock dividend, stock split, recapitalization, or other similar transaction effected without the receipt of consideration that results in an increase to the number of outstanding shares of Class A Common Stock, as applicable.

(2)	The number of shares of Class A Common Stock being registered hereunder are being registered for sale by the selling securityholders named in this Registration Statement, and represents 2,839,005 shares of Common Stock issued in the PIPE Financing.

(3)

Pursuant to Rule 457(c) under the Securities Act, and solely for the purpose of calculating the registration fee, the proposed maximum offering price per share is $17.66, which is the average of the high and low prices of shares of Class A Common Stock on The Nasdaq Global Market on October 17, 2024 (such date being within five business days of the date that this Registration Statement was filed with the U.S. Securities and Exchange Commission).