0001546927-16-000514.txt : 20160812 0001546927-16-000514.hdr.sgml : 20160812 20160812163553 ACCESSION NUMBER: 0001546927-16-000514 CONFORMED SUBMISSION TYPE: 13F-HR/A PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160630 FILED AS OF DATE: 20160812 DATE AS OF CHANGE: 20160812 EFFECTIVENESS DATE: 20160812 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Opaleye Management Inc. CENTRAL INDEX KEY: 0001595855 IRS NUMBER: 205648796 STATE OF INCORPORATION: MA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR/A SEC ACT: 1934 Act SEC FILE NUMBER: 028-15896 FILM NUMBER: 161828727 BUSINESS ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617-904-9195 MAIL ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 13F-HR/A 1 primary_doc.xml 13F-HR/A LIVE false true false 0001595855 XXXXXXXX 06-30-2016 06-30-2016 true 1 RESTATEMENT false Opaleye Management Inc.

175 Federal Street, 6th Floor Boston MA 02110

13F HOLDINGS REPORT 028-15896 N James Silverman 617-229-5085 James Silverman Boston MA 08-12-2016 0 49 149709 INFORMATION TABLE 2 infotable.xml ADAMAS PHARMACEUTICALS INC COM 00548A106 4542 300000 SH SOLE 300000 0 0 ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 326 40000 SH SOLE 40000 0 0 AFFIMED NV COM N01045108 1476 595000 SH SOLE 595000 0 0 AGIOS PHARMACEUTICALS COM 00847X104 3561 85000 SH SOLE 85000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 2870 120000 SH SOLE 120000 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 3802 1760000 SH SOLE 1760000 0 0 AQUINOX PHARMACEUTICALS INC COM 03842B101 1953 295000 SH SOLE 295000 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 9238 1250000 SH SOLE 1250000 0 0 AURIS MED HLDG AG COM H03579101 1425 340000 SH SOLE 340000 0 0 AXOGEN INC COM 05463X106 14586 2120000 SH SOLE 2120000 0 0 BIOLINERX LTD SPONSORED ADR 09071M106 223 250000 SH SOLE 250000 0 0 BLUEPRINT MEDICINES CORP COM 09627Y109 5063 250000 SH SOLE 250000 0 0 CARA THERAPEUTICS INC COM 140755109 4016 835000 SH SOLE 835000 0 0 CHIMERIX INC COM 16934W106 2653 675000 SH SOLE 675000 0 0 CIDARA THERAPEUTICS INC COM 171757107 443 43000 SH SOLE 43000 0 0 CODEXIS INC COM 192005106 4749 1178500 SH SOLE 1178500 0 0 CORIUM INTL INC COM 21887L107 1249 360000 SH SOLE 360000 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 2094 125000 SH SOLE 125000 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 1634 160000 SH SOLE 160000 0 0 EAGLE PHARMACEUTICALS INC COM 269796108 1940 50000 SH SOLE 50000 0 0 EDGE THERAPEUTICS INC COM 279870109 2281 225600 SH SOLE 225600 0 0 EVOKE PHARMA INC COM 30049G104 891 130000 SH SOLE 130000 0 0 FIBROGEN INC COM 31572Q808 5415 330000 SH SOLE 330000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 4413 695000 SH SOLE 695000 0 0 GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 2522 152000 SH SOLE 152000 0 0 HORIZON PHARMA PLC COM G4617B105 3294 200000 SH SOLE 200000 0 0 IMMUNOMEDICS INC COM 452907108 3016 1300000 SH SOLE 1300000 0 0 IMPRIMIS PHARMACEUTICALS INC COM NEW 45323A201 4766 1267500 SH SOLE 1267500 0 0 INNOCOLL HOLDINGS PLC SHS G4783X105 1460 265000 SH SOLE 265000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780VAA0 4799 645000 SH SOLE 645000 0 0 INTEC PHARMA LTD JERUSALEM SHS M53644106 2989 650000 SH SOLE 650000 0 0 LION BIOTECHNOLOGIES INC COM 53619R102 2106 260000 SH SOLE 260000 0 0 MACROGENICS INC COM 556099109 3023 112000 SH SOLE 112000 0 0 MEDGENICS INC COM NEW 58436Q203 10823 1950000 SH SOLE 1950000 0 0 NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 2025 270000 SH SOLE 270000 0 0 NEURODERM LTD ORD SHS M74231107 853 52500 SH SOLE 52500 0 0 OCULAR THERAPEUTIX INC COM 67576A100 1287 260000 SH SOLE 260000 0 0 PARATEK PHARMACEUTICALS INC COM 699374302 2041 146700 SH SOLE 146700 0 0 PROTALIX BIOTHERAPEUTICS INC COM 74365AAB7 5248 8200000 SH SOLE 8200000 0 0 PROTEOSTASIS THERAPEUTICS IN COM 74373B109 1274 105000 SH SOLE 105000 0 0 SERES THERAPEUTICS INC COM 81750R102 1670 57500 SH SOLE 57500 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 2546 125000 SH SOLE 125000 0 0 TENAX THERAPEUTICS INC COM 88032L100 1190 465000 SH SOLE 465000 0 0 TG THERAPEUTICS INC COM 88322Q108 1061 175000 SH SOLE 175000 0 0 TONIX PHARMACEUTICALS HLDG C COM NEW 890260201 1592 800000 SH SOLE 800000 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1751 195000 SH SOLE 195000 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3179 65000 SH SOLE 65000 0 0 XENON PHARMACEUTICALS INC COM 98420N105 2419 410000 SH SOLE 410000 0 0 ZOGENIX INC COM NEW 98978L105 1932 240000 SH SOLE 240000 0 0