0001546927-16-000499.txt : 20160527 0001546927-16-000499.hdr.sgml : 20160527 20160527152910 ACCESSION NUMBER: 0001546927-16-000499 CONFORMED SUBMISSION TYPE: 13F-HR/A PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160331 FILED AS OF DATE: 20160527 DATE AS OF CHANGE: 20160527 EFFECTIVENESS DATE: 20160527 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Opaleye Management Inc. CENTRAL INDEX KEY: 0001595855 IRS NUMBER: 205648796 STATE OF INCORPORATION: MA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR/A SEC ACT: 1934 Act SEC FILE NUMBER: 028-15896 FILM NUMBER: 161682209 BUSINESS ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617-904-9195 MAIL ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 13F-HR/A 1 primary_doc.xml 13F-HR/A LIVE false true false 0001595855 XXXXXXXX 03-31-2016 03-31-2016 true 1 RESTATEMENT false Opaleye Management Inc.

175 Federal Street, 6th Floor Boston MA 02110

13F HOLDINGS REPORT 028-15896 N James Silverman 617-229-5085 James Silverman Boston MA 05-27-2016 0 52 160362 INFORMATION TABLE 2 infotable.xml ACHAOGEN INC COM 004449104 704 255000 SH SOLE 255000 0 0 ACLARIS THERAPEUTICS INC COM 00461U105 341 18000 SH SOLE 18000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 6064 320000 SH SOLE 320000 0 0 ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 1425 175300 SH SOLE 175300 0 0 AFFIMED N V COM N01045108 2281 610000 SH SOLE 610000 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 4263 105000 SH SOLE 105000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 5148 220000 SH SOLE 220000 0 0 AMARIN CORP PLC COM 023111206 2693 1760000 SH SOLE 1760000 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 7988 1250000 SH SOLE 1250000 0 0 AURIS MED HLDG AG COM H03579101 1238 340000 SH SOLE 340000 0 0 AXOGEN INC COM 05463X106 11363 2120000 SH SOLE 2120000 0 0 BIOLINERX LTD SPONSORED ADR 09071M106 255 250000 SH SOLE 250000 0 0 BLUEPRINT MEDICINES CORP COM 09627Y109 3971 220000 SH SOLE 220000 0 0 CARA THERAPEUTICS INC COM 140755109 5318 855000 SH SOLE 855000 0 0 CHIASMA INC COM 16706W102 183 20000 SH SOLE 20000 0 0 CHIMERIX INC COM 16934W106 3449 675000 SH SOLE 675000 0 0 CODEXIS INC COM 192005106 3665 1178500 SH SOLE 1178500 0 0 CORIUM INTL INC COM 21887L107 1390 360000 SH SOLE 360000 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 1440 121000 SH SOLE 121000 0 0 CYTRX CORP COM PAR $.001 838828509 4118 1440000 SH SOLE 1440000 0 0 DEPOMED INC COM 249908104 4527 325000 SH SOLE 325000 0 0 EAGLE PHARMACEUTICALS INC COM 269796108 2430 60000 SH SOLE 60000 0 0 EDGE THERAPEUTICS INC COM 279870109 1693 185000 SH SOLE 185000 0 0 EVOKE PHARMA COM 30049G104 662 130000 SH SOLE 130000 0 0 FIBROGEN INC COM 31572Q808 6919 325000 SH SOLE 325000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 3847 590000 SH SOLE 590000 0 0 GERON CORP COM 374163103 3869 1325000 SH SOLE 1325000 0 0 IMMUNOMEDICS INC COM 452907108 3313 1325000 SH SOLE 1325000 0 0 IMPRIMIS PHARMACEUTICALS INC COM NEW 45323A201 4963 1250000 SH SOLE 1250000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780VAA0 4773 645000 SH SOLE 645000 0 0 INTEC PHARMA LTD JERUSALEM SHS M53644106 2629 638000 SH SOLE 638000 0 0 MEDGENICS INC COM NEW 58436Q203 6854 1557700 SH SOLE 1557700 0 0 MEDIVATION INC COM 58501N101 667 14500 SH SOLE 14500 0 0 NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 2453 273800 SH SOLE 273800 0 0 NEKTAR THERAPEUTICS COM 640268108 688 50000 SH SOLE 50000 0 0 NEURODERM LTD ORD SHS M74231107 544 38500 SH SOLE 38500 0 0 NIVALIS THERAPEUTICS INC COM 65481J109 417 100000 SH SOLE 100000 0 0 OHR PHARMACEUTICAL INC COM NEW 67778H200 1175 366000 SH SOLE 366000 0 0 OPHTHOTECH CORP COM 683745103 3382 80000 SH SOLE 80000 0 0 PROTALIX BIOTHERAPEUTICS INC COM 74365AAB7 6892 8200000 SH SOLE 8200000 0 0 PROTEON THERAPEUTICS INC COM 7437IL109 1161 150000 SH SOLE 150000 0 0 PROTHENA CORP PLC SHS G72800108 576 14000 SH SOLE 14000 0 0 RETROPHIN INC COM 761299106 2049 150000 SH SOLE 150000 0 0 SAGE THERAPEUTICS INC COM 78667J108 5290 165000 SH SOLE 165000 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 1906 125000 SH SOLE 125000 0 0 TENAX THERAPEUTICS INC COM 88032L100 1024 499600 SH SOLE 499600 0 0 TG THERAPEUTICS INC COM 88322Q108 3536 415000 SH SOLE 415000 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1804 195000 SH SOLE 195000 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 6964 110000 SH SOLE 110000 0 0 XENON PHARMACEUTICALS INC COM 98420N105 2796 400000 SH SOLE 400000 0 0 XOMA CORP DEL COM 98419J107 1044 1350000 SH SOLE 1350000 0 0 ZOGENIX INC COM NEW 98978L204 2218 240000 SH SOLE 240000 0 0