0001546927-16-000408.txt : 20160212 0001546927-16-000408.hdr.sgml : 20160212 20160212125729 ACCESSION NUMBER: 0001546927-16-000408 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20151231 FILED AS OF DATE: 20160212 DATE AS OF CHANGE: 20160212 EFFECTIVENESS DATE: 20160212 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Opaleye Management Inc. CENTRAL INDEX KEY: 0001595855 IRS NUMBER: 205648796 STATE OF INCORPORATION: MA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15896 FILM NUMBER: 161417125 BUSINESS ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617-904-9195 MAIL ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001595855 XXXXXXXX 12-31-2015 12-31-2015 false Opaleye Management Inc.

175 Federal Street, 6th Floor Boston MA 02110

13F HOLDINGS REPORT 028-15896 N James Silverman 617-229-5085 James Silverman Boston MA 02-12-2016 0 53 239178 INFORMATION TABLE 2 infotable.xml ACCELERATED DIAGNOSTICS INC COM 00430H102 1612 75000 SH SOLE 75000 0 0 ACHAOGEN INC COM OO4449104 718 125000 SH SOLE 125000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 5380 190000 SH SOLE 190000 0 0 AFFIMED N V COM N01045108 4236 595000 SH SOLE 595000 0 0 AGILE THERAPEUTICS INC COM 00847L100 2928 300000 SH SOLE 300000 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 2147 65000 SH SOLE 65000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 4529 150000 SH SOLE 150000 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 3326 1760000 SH SOLE 1760000 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 8188 1310000 SH SOLE 1310000 0 0 AURIS MED HLDG AG COM H03579101 1834 375000 SH SOLE 375000 0 0 AVINGER INC COM 053734109 4315 190000 SH SOLE 190000 0 0 AXOGEN INC COM 05463X106 10600 2120000 SH SOLE 2120000 0 0 BIOLINERX LTD SPONSORED ADR 09071M106 325 250000 SH SOLE 250000 0 0 BLUEPRINT MEDICINES CORP COM 09627Y109 7244 275000 SH SOLE 275000 0 0 CARA THERAPEUTICS INC COM 140755109 7199 427000 SH SOLE 427000 0 0 CELLECTIS S A SPONSORED ADS 15117K103 1552 50000 SH SOLE 50000 0 0 CEMPRA INC COM 15130J109 6226 200000 SH SOLE 200000 0 0 CODEXIS INC COM 192005106 6768 1600000 SH SOLE 1600000 0 0 CORIUM INTL INC COM 21887L107 2883 355000 SH SOLE 355000 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 1682 110000 SH SOLE 110000 0 0 CYTRX CORP COM PAR $.001 838828509 3816 1440000 SH SOLE 1440000 0 0 DEPOMED INC COM 249908104 5439 300000 SH SOLE 300000 0 0 EAGLE PHARMACEUTICALS INC COM 269796108 7537 85000 SH SOLE 85000 0 0 EVOKE PHARMA INC COM 30049G104 429 130000 SH SOLE 130000 0 0 FIBROGEN INC COM 31572Q808 9903 325000 SH SOLE 325000 0 0 FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 3053 250000 SH SOLE 250000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 4055 500000 SH SOLE 500000 0 0 GERON CORP COM 374163103 8833 1825000 SH SOLE 1825000 0 0 IMMUNOMEDICS INC COM 452907108 890 290000 SH SOLE 290000 0 0 IMPRIMIS PHARMACEUTICALS INC COM NEW 45323A201 8351 1205000 SH SOLE 1205000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780VAA0 7308 645000 SH SOLE 645000 0 0 INTEC PHARMA LTD JERUSALEM SHS M53644106 3377 630000 SH SOLE 630000 0 0 LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459904 3780 140000 SH SOLE 140000 0 0 MACROGENICS INC COM 556099109 1084 35000 SH SOLE 35000 0 0 MEDGENICS INC COM NEW 58436Q203 8368 1390000 SH SOLE 1390000 0 0 NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 2116 220000 SH SOLE 220000 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 3111 55000 SH SOLE 55000 0 0 OPHTHOTECH CORP COM 683745103 8246 105000 SH SOLE 105000 0 0 PROTALIX BIOTHERAPEUTICS INC COM 74365AAB7 8262 8100000 SH SOLE 8100000 0 0 RELYPSA INC COM 759531106 6235 220000 SH SOLE 220000 0 0 RETROPHIN INC COM 761299106 6655 345000 SH SOLE 345000 0 0 SAGE THERAPEUTICS INC COM 78667J108 5830 100000 SH SOLE 100000 0 0 SANGAMO BIOSCIENCES INC COM 800677106 548 60000 SH SOLE 60000 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 5645 420000 SH SOLE 420000 0 0 TENAX THERAPEUTICS INC COM 88032L100 1771 540000 SH SOLE 540000 0 0 TG THERAPEUTICS INC COM 88322Q108 3579 300000 SH SOLE 300000 0 0 TONIX PHARMACEUTICALS HLDG C COM NEW 890260201 4334 565000 SH SOLE 565000 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 2648 210000 SH SOLE 210000 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 12340 110000 SH SOLE 110000 0 0 VITAE PHARMACEUTICALS INC COM 92847N103 1059 58500 SH SOLE 58500 0 0 XENON PHARMACEUTICALS INC COM 98420N105 2412 300000 SH SOLE 300000 0 0 XOMA CORP DEL COM 98419J107 2261 1700000 SH SOLE 1700000 0 0 ZOGENIX INC COM NEW 98978L105 2211 150000 SH SOLE 150000 0 0