0001546927-15-000231.txt : 20150814 0001546927-15-000231.hdr.sgml : 20150814 20150814102749 ACCESSION NUMBER: 0001546927-15-000231 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150630 FILED AS OF DATE: 20150814 DATE AS OF CHANGE: 20150814 EFFECTIVENESS DATE: 20150814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Opaleye Management Inc. CENTRAL INDEX KEY: 0001595855 IRS NUMBER: 205648796 STATE OF INCORPORATION: MA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15896 FILM NUMBER: 151053272 BUSINESS ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617-904-9195 MAIL ADDRESS: STREET 1: 175 FEDERAL STREET, 6TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001595855 XXXXXXXX 06-30-2015 06-30-2015 false Opaleye Management Inc.

175 Federal Street, 6th Floor Boston MA 02110

13F HOLDINGS REPORT 028-15896 N James Silverman 617-229-5085 James Silverman Boston MA 08-14-2015 0 46 251326 INFORMATION TABLE 2 infotable.xml ACCELERATE DIAGNOSTICS INC COM 00430H102 2596 100600 SH SOLE 100600 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 3933 150000 SH SOLE 150000 0 0 AFFIMED NV COM N01045108 7951 590300 SH SOLE 590300 0 0 AGILE THERAPEUTICS INC COM 00847L100 472 55000 SH SOLE 55000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 13121 190000 SH SOLE 190000 0 0 AMARIN CORP PLC COM 023111206 4315 1754000 SH SOLE 1754000 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 12405 1500000 SH SOLE 1500000 0 0 AURIS MED HLDG AG COM H03579101 1725 355000 SH SOLE 355000 0 0 AVINGER INC COM 053734109 2688 208200 SH SOLE 208200 0 0 AXOGEN INC COM 05463X106 6657 2120000 SH SOLE 2120000 0 0 BIOLINERX LTD COM 09071M106 495 250000 SH SOLE 250000 0 0 CARA THERAPEUTICS INC COM 140755109 4131 340000 SH SOLE 340000 0 0 CELGENE CORP RIGHTS 151020112 950 456492 SH SOLE 456492 0 0 CEMPRA INC COM 15130J109 16836 490000 SH SOLE 490000 0 0 CHIMERIX INC COM 16934W106 20328 440000 SH SOLE 440000 0 0 CLOVIS ONCOLOGY INC COM 189464100 7909 90000 SH SOLE 90000 0 0 CODEXIS INC COM 192005106 6706 1724000 SH SOLE 1724000 0 0 DERMIRA INC COM 24983L104 330 18800 SH SOLE 18800 0 0 EAGLE PHARMACEUTICALS INC COM 269796108 4043 50000 SH SOLE 50000 0 0 EVOKE PHARMA INC COM 30049G104 1355 259100 SH SOLE 259100 0 0 FIBROGEN INC COM 31572Q808 7638 325000 SH SOLE 325000 0 0 FLAMEL TECHNOLOGIES SA COM 338488109 6569 310000 SH SOLE 310000 0 0 FOAMIX PHARMACEUTICALS LTD COM M46135105 871 85000 SH SOLE 85000 0 0 GERON CORP COM 374163103 7811 1825000 SH SOLE 1825000 0 0 IMPRIMIS PHARMACEUTICALS INC COM 45323A201 9797 1205000 SH SOLE 1205000 0 0 INNOCOLL AG COM 45780Q103 1481 101200 SH SOLE 101200 0 0 INOTEK PHARMACEUTICALS CORP COM 45780VAA0 2963 604700 SH SOLE 604700 0 0 INSYS THERAPEUTICS INC NEW COM NEW 45824V209 3197 89000 SH SOLE 89000 0 0 MACROGENICS INC COM 556099109 3417 90000 SH SOLE 90000 0 0 MEDGENICS INC COM NEW 58436Q203 6437 1050000 SH SOLE 1050000 0 0 MIMEDX GROUP INC COM 602496101 7151 617000 SH SOLE 617000 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 6925 145000 SH SOLE 145000 0 0 NEURODERM LTD COM M74231107 399 26000 SH SOLE 26000 0 0 OPHTHOTECH CORP COM 683745103 5487 105000 SH SOLE 105000 0 0 PROTALIX BIOTHERAPEUTICS INC COM 74365AAB7 4885 2505000 SH SOLE 2505000 0 0 RETROPHIN INC COM 761299106 15249 460000 SH SOLE 460000 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 9084 535000 SH SOLE 535000 0 0 TENAX THERAPEUTICS INC COM 88032L100 2343 635000 SH SOLE 635000 0 0 TETRAPHASE PHARMACEUTICALS I COM 88165N105 3084 65000 SH SOLE 65000 0 0 TONIX PHARMACEUTICALS HLDG C COM 890260201 1704 190000 SH SOLE 190000 0 0 TRACON PHARMACEUTICALS INC COM 89237H10A 138 12172 SH SOLE 12172 0 0 TRILLIUM THERAPEUTICS INC COM 89620X506 5455 250000 SH SOLE 250000 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 11263 110000 SH SOLE 110000 0 0 XOMA CORP DEL COM 98419J107 2522 650000 SH SOLE 650000 0 0 ZOGENIX INC COM 98978L105 1533 912500 SH SOLE 912500 0 0 ZS PHARMA INC COM 98979G105 4977 95000 SH SOLE 95000 0 0