SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Chione Ltd (Last) (First) (Middle) SIMOU MENARDOU 8 RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol Karyopharm Therapeutics Inc. [ KPTI ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 11/12/2013
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
COMMON STOCK	11/12/2013		C		10,258,079(1)	A	$0	10,258,079(1)	D
COMMON STOCK	11/12/2013		C		10,258,079(1)	A	$0	10,258,079(1)	I	See Footnotes(2)(3)(4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Preferred Stock	(5)	11/12/2013		C			20,000,000	(5)	(5)	Common Stock	6,060,606	(5)	0	I	See Footnotes(3)(4)(6)
Series A-2 Preferred Stock	(5)	11/12/2013		C			6,086,957	(5)	(5)	Common Stock	1,844,532	(5)	0	I	See Footnotes(3)(4)(6)
Series A-3 Preferred Stock	(5)	11/12/2013		C			1,764,706	(5)	(5)	Common Stock	534,759	(5)	0	I	See Footnotes(3)(4)(6)
Series B Preferred Stock	(5)	11/12/2013		C			6,000,000	(5)	(5)	Common Stock	1,818,182	(5)	0	I	See Footnotes(3)(4)(6)

1. Name and Address of Reporting Person* Chione Ltd (Last) (First) (Middle) SIMOU MENARDOU 8 RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Czernik Marcin (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 00000 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Hadjimichael Andreas (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 00000 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Hadjimichael Amalia (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 00000 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Smolokowski Wiaczeslaw (Last) (First) (Middle) CHALET LENOTCHKA CH.DE BARNOUD 1885 CHESIERES (Street) SWITZERLAND G4 00000 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. Represents the total number of shares received upon the automatic conversion of shares of the issuer's Series A Preferred Stock, Series A-2 Preferred Stock, Series A-3 Preferred Stock and Series B Preferred Stock.

2. Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. The shares owned by Chione do not include the 3,193,473 shares of the issuer's Common Stock held by Plio Limited, which has the same directors as Chione.

3. Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

4. Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

5. Each share of Preferred Stock converted into Common Stock on a 1 for 3.3 basis automatically upon the closing of the issuer's initial public offering. The total number of shares of Common Stock issued upon such conversion in respect of each series of Preferred Stock is shown in column 7. The shares of Preferred Stock had no expiration date.

6. The shares of Preferred Stock were directly owned by Chione. Chione's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, may be deemed to have shared voting and investment power and beneficial ownership of the shares of Preferred Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to have shared voting and investment power and beneficial ownership of the shares of Preferred Stock directly owned by Chione. The shares owned by Chione do not include the shares of the issuer's Series A-4 Preferred Stock and Series B Preferred Stock previously held by Plio Limited, which has the same directors as Chione.

Remarks:

Exhibit Index Exhibit 24.1 - Power of Attorney, dated November 5. 2013, made by Marcin Czernik and Chione Limited in favor of Simon Prisk (previously filed) Exhibit 24.2 - Power of Attorney, dated November 5. 2013, made by Andreas Hadjimichael and Chione Limited in favor of Simon Prisk (previouslyfiled) Exhibit 24.3 - Power of Attorney, dated November 5. 2013, made by Amalia Hadjimichael and Chione Limited in favor of Simon Prisk (previously filed) Exhibit 24.4 - Power of Attorney, dated November 5. 2013, made by Wiaczeslaw Smolokowski in favor of Simon Prisk (previously filed) Exhibit 99.1 - Joint Filer Information (filed herewith) Exhibit 99.2 - Joint Filing Agreement (previously filed). All previously filed Exhibits were filed with the Form 3 of the reporting persons, filed on November 8, 2013.

	/s/ Chione Limited, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/14/2013
	/s/ Marcin Czernik, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/14/2013
	/s/ Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/14/2013
	/s/ Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/14/2013
	/s/ Wiaczeslaw Smolokowski, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/14/2013
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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