SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Chione Ltd (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 11/05/2013	3. Issuer Name and Ticker or Trading Symbol Karyopharm Therapeutics Inc. [ KPTI ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Preferred Stock	(1)	(1)	Common Stock	6,060,606	(1)	I	See Footnotes(2)(3)(4)(5)
Series A-2 Preferred Stock	(1)	(1)	Common Stock	1,844,532	(1)	I	See Footnotes(2)(3)(4)(5)
Series A-3 Preferred Stock	(1)	(1)	Common Stock	534,759	(1)	I	See Footnotes(2)(3)(4)(5)
Series B Preferred Stock	(1)	(1)	Common Stock	1,818,182	(1)	I	See Footnotes(2)(3)(4)(5)

1. Name and Address of Reporting Person* Chione Ltd (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Czernik Marcin (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Hadjimichael Andreas (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Hadjimichael Amalia (Last) (First) (Middle) SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 (Street) 6015 LARNACA G4 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Smolokowski Wiaczeslaw (Last) (First) (Middle) CHALET LENOTCHKA CH.DE BARNOUD 1885 CHESIERES (Street) SWITZERLAND (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. Each share of Preferred Stock is convertible into Common Stock on a 1 for 3.3 basis at any time at the holder's election and automatically upon the closing of the issuer's initial public offering. The total number of shares of Common Stock issuable upon such conversion in respect of each series of Preferred Stock is shown in column 3. The shares of Preferred Stock have no expiration date.

2. Shares of Preferred Stock owned directly by Chione Limited ("Chione"). Upon conversion of those shares of Preferred Stock, the shares of Common Stock issuable upon such conversion will be owned directly by Chione.

3. Chione's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Preferred Stock directly owned by Chione (and of the Common Stock issuable upon conversion of those shares of Preferred Stock). Wiaczeslaw Smolokowski, the sole shareholder of Chione, may be deemed to share voting and investment power and beneficial ownership of the shares of Preferred Stock directly owned by Chione (and of the Common Stock issuable upon conversion of those shares of Preferred Stock). The shares owned by Chione do not include the shares of the issuer's Series A-4 Preferred Stock and Series B Preferred Stock (and the 3,193,473 shares of Common Stock issuable upon conversion of those shares of Preferred Stock) held (or to be held) by Plio Limited, which has the same directors as Chione.

4. Each reporting person states that neither the filing of this Form 3 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 3. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

5. Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 3 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Remarks:

Exhibit Index Exhibit 24.1 - Power of Attorney, dated November 5. 2013, made by Marcin Czernik and Chione Limited in favor of Simon Prisk (filed herewith) Exhibit 24.2 - Power of Attorney, dated November 5. 2013, made by Andreas Hadjimichael and Chione Limited in favor of Simon Prisk (filed herewith) Exhibit 24.3 - Power of Attorney, dated November 5. 2013, made by Amalia Hadjimichael and Chione Limited in favor of Simon Prisk (filed herewith) Exhibit 24.4 - Power of Attorney, dated November 5. 2013, made by Wiaczeslaw Smolokowski in favor of Simon Prisk (filed herewith) Exhibit 99.1 - Joint Filer Information (filed herewith) Exhibit 99.2 - Joint Filing Agreement (filed herewith)

	Chione Limited, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/07/2013
	Marcin Czernik, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/07/2013
	Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/07/2013
	Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/07/2013
	Wiaczeslaw Smolokowski, by /s/ Simon Prisk, as attorney-in fact by power of attorney	11/07/2013
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
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