The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABIVAX SA | SPONSORED ADS | 00370M103 | 22,791,000 | 2,130,000 | SH | DFND | 1 | 2,130,000 | 0 | 0 | ||
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 27,420,680 | 1,211,696 | SH | DFND | 1 | 1,211,696 | 0 | 0 | ||
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 48,603,000 | 2,550,000 | SH | DFND | 1 | 2,550,000 | 0 | 0 | ||
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 46,785,556 | 3,142,079 | SH | DFND | 1 | 3,142,079 | 0 | 0 | ||
| AMBRX BIOPHARMA INC | COM | 641871108 | 159,929,440 | 11,231,000 | SH | DFND | 1 | 11,231,000 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 37,412,500 | 625,000 | SH | DFND | 1 | 625,000 | 0 | 0 | ||
| ARCELLX INC | COMMON STOCK | 03940C100 | 94,350,000 | 1,700,000 | SH | DFND | 1 | 1,700,000 | 0 | 0 | ||
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 35,098,000 | 5,450,000 | SH | DFND | 1 | 5,450,000 | 0 | 0 | ||
| AXONICS INC | COM | 05465P101 | 15,557,500 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | ||
| BIOATLA INC | COM | 09077B104 | 2,905,543 | 1,181,115 | SH | DFND | 1 | 1,181,115 | 0 | 0 | ||
| BIOHAVEN LTD | COM | G1110E107 | 3,508,016 | 81,963 | SH | DFND | 1 | 81,963 | 0 | 0 | ||
| BIOMEA FUSION INC | COM | 09077A106 | 51,849,061 | 3,570,872 | SH | DFND | 1 | 3,570,872 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 135,004,506 | 3,344,179 | SH | DFND | 1 | 3,344,179 | 0 | 0 | ||
| CARGO THERAPEUTICS INC | COM | 14179K101 | 27,376,333 | 1,182,563 | SH | DFND | 1 | 1,182,563 | 0 | 0 | ||
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 4,470,336 | 561,600 | SH | DFND | 1 | 561,600 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 40,917,000 | 1,150,000 | SH | DFND | 1 | 1,150,000 | 0 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 42,516,000 | 1,800,000 | SH | DFND | 1 | 1,800,000 | 0 | 0 | ||
| DISC MEDICINE INC | COM | 254604101 | 7,220,000 | 125,000 | SH | DFND | 1 | 125,000 | 0 | 0 | ||
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 27,918,760 | 2,551,989 | SH | DFND | 1 | 2,551,989 | 0 | 0 | ||
| EDITAS MEDICINE INC | COM | 28106W103 | 5,065,000 | 500,000 | SH | Put | DFND | 1 | 500,000 | 0 | 0 | |
| EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | 139,543,611 | 6,038,235 | SH | DFND | 1 | 6,038,235 | 0 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 3,439,649 | 593,043 | SH | DFND | 1 | 593,043 | 0 | 0 | ||
| HARPOON THERAPEUTICS INC | COM NEW | 41358P205 | 22,550,934 | 2,349,060 | SH | DFND | 1 | 1,584,060 | 0 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 16,011,000 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | ||
| IMMUNEERING CORP | CLASS A COM | 45254E107 | 30,902,075 | 4,204,364 | SH | DFND | 1 | 4,204,364 | 0 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | 49,081,450 | 1,165,000 | SH | DFND | 1 | 1,165,000 | 0 | 0 | ||
| INSMED INC | COM PAR $.01 | 457669307 | 17,819,250 | 575,000 | SH | DFND | 1 | 575,000 | 0 | 0 | ||
| KORRO BIO INC | COM | 500946108 | 25,363,118 | 529,170 | SH | DFND | 1 | 529,170 | 0 | 0 | ||
| LANTHEUS HLDGS INC | COM | 516544103 | 4,650,000 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | ||
| LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 14,189,440 | 2,353,141 | SH | DFND | 1 | 2,353,141 | 0 | 0 | ||
| MARINUS PHARMACEUTICALS INC | COM NEW | 56854Q200 | 35,327,500 | 3,250,000 | SH | DFND | 1 | 3,250,000 | 0 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 512,961,779 | 8,494,151 | SH | DFND | 1 | 8,494,151 | 0 | 0 | ||
| NEUMORA THERAPEUTICS INC. | COM | 640979100 | 1,573,596 | 92,293 | SH | DFND | 1 | 92,293 | 0 | 0 | ||
| NEUROGENE INC | COM | 64135M105 | 14,460,968 | 746,180 | SH | DFND | 1 | 746,180 | 0 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 34,468,904 | 2,456,800 | SH | DFND | 1 | 2,456,800 | 0 | 0 | ||
| PHARVARIS N V | COM | N69605108 | 48,006,453 | 1,711,460 | SH | DFND | 1 | 1,711,460 | 0 | 0 | ||
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 | 14,110,927 | 633,345 | SH | DFND | 1 | 633,345 | 0 | 0 | ||
| RAPT THERAPEUTICS INC | COM | 75382E109 | 12,344,238 | 496,750 | SH | DFND | 1 | 496,750 | 0 | 0 | ||
| RAYZEBIO INC | COM | 75525N107 | 75,441,927 | 1,213,478 | SH | DFND | 1 | 1,213,478 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 25,283,500 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 13,486,500 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | ||
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 20,165,962 | 937,080 | SH | DFND | 1 | 937,080 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 5,721,865 | 1,087,807 | SH | DFND | 1 | 1,087,807 | 0 | 0 | ||
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 25,391,750 | 1,175,000 | SH | DFND | 1 | 1,175,000 | 0 | 0 | ||
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 44,983,796 | 2,221,422 | SH | DFND | 1 | 2,221,422 | 0 | 0 | ||
| VAXCYTE INC | COM | 92243G108 | 41,762,000 | 665,000 | SH | DFND | 1 | 665,000 | 0 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 4,879,000 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | ||
| VYNE THERAPEUTICS INC | COM | 92941V308 | 3,248,803 | 1,394,336 | SH | DFND | 1 | 1,394,336 | 0 | 0 | ||