SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
X	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Hatteras Venture Advisors IV SBIC, LLC (Last) (First) (Middle) 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol Clearside Biomedical, Inc. [ CLSD ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group
	3. Date of Earliest Transaction (Month/Day/Year) 01/17/2017
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	01/17/2017		S		9,806	D	$8.92(1)	2,080,364	I	See Footnote(2)
Common Stock	01/18/2017		S		12,258	D	$8.64(3)	2,068,106	I	See Footnote(2)
Common Stock	01/19/2017		S		7,592	D	$8.22(4)	2,060,514	I	See Footnote(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person* Hatteras Venture Advisors IV SBIC, LLC (Last) (First) (Middle) 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

1. Name and Address of Reporting Person* Hatteras Venture Partners IV SBIC, LP (Last) (First) (Middle) 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

1. Name and Address of Reporting Person* Crumpler John (Last) (First) (Middle) C/O HATTERAS VENTURES 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

1. Name and Address of Reporting Person* INGRAM ROBERT ALEXANDER (Last) (First) (Middle) C/O HATTERAS VENTURES 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

1. Name and Address of Reporting Person* LEE KENNETH B JR (Last) (First) (Middle) C/O HATTERAS VENTURES 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

1. Name and Address of Reporting Person* Reed Douglas MD (Last) (First) (Middle) C/O HATTERAS VENTURES 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

1. Name and Address of Reporting Person* Thorp Clay (Last) (First) (Middle) C/O HATTERAS VENTURES 280 S. MANGUM STREET, SUITE 350 (Street) DURHAM NC 27701 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) X Other (specify below) May be part of a 13(d) Group

Explanation of Responses:

1. This transaction was executed in multiple trades at prices ranging from $8.68 to $9.22. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.

2. The reportable securities are owned directly by Hatteras Venture Partners IV SBIC, LP ("HVP IV"). Hatteras Venture Advisors IV SBIC, LLC is the general partner of HVP IV (the "GP"). The securities directly held by HVP IV are indirectly held by the individual managing members of GP (each, a "GP Managing Member" and collectively, the "GP Managing Members"). The GP Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The GP Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each GP Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any GP Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.

3. This transaction was executed in multiple trades at prices ranging from $8.42 to $8.79. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.

4. This transaction was executed in multiple trades at prices ranging from $8.01 to $8.65. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.

	/s/ Thomas A. Allen, attorney-in-fact for Hatteras Venture Advisors IV SBIC, LLC	01/19/2017
	/s/ Thomas A. Allen, attorney-in-fact for Hatteras Venture Advisors IV SBIC, LLC, the general partner of Hatteras Venture Partners IV SBIC, LP	01/19/2017
	/s/ Thomas A. Allen, attorney-in-fact for John C. Crumpler	01/19/2017
	/s/ Thomas A. Allen, attorney-in-fact for Robert A. Ingram	01/19/2017
	/s/ Thomas A. Allen, attorney-in-fact for Kenneth B. Lee	01/19/2017
	/s/ Thomas A. Allen, attorney-in-fact for Douglas Reed	01/19/2017
	/s/ Thomas A. Allen, attorney-in-fact for Clay B. Thorp	01/19/2017
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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