Exhibit 107.1

Calculation of Filing Fee Tables

Form S-3

(Form Type)

Annexon, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial effective date

Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward

Newly Registered Securities

Fees to Be Paid

Equity

Common Stock, par value $0.001 per share

(1)(2)

(1)

Equity

Preferred Stock, par value $0.001 per share

(1)(2)

(1)

Debt

Debt Securities

(1)

(1)

Other

Warrants

(1)

(1)

Other

Units

(1)

(1)

Unallocated (Universal) Shelf

Rule 457(o)

(1)(2)

(1)

$200,000,000(3)

$92.70 per $1,000,000

$18,540(4)

Fees Previously Paid

Equity

Common Stock, par value $0.001 per share

Rule 457(o)

—

—

$100,000,000

$109.10 per $1,000,000

$10,910(5)

Carry Forward Securities
Carry Forward Securities	Equity	Common Stock, par value $0.001 per share	Rule 415(a)(6)	—	—	$100,000,000	$109.10 per $1,000,000	$10,910(5)	S-3	No. 333-258863	August 16, 2021	$10,910
	Total Offering Amounts					$300,000,000(3)		$29,450
	Total Fees Previously Paid							$10,910
	Total Fee Offsets							—
	Net Fee Due							$18,540

(1) An unspecified number of securities or aggregate principal amount, as applicable, is being registered as may from time to time be offered at unspecified prices and, in addition, an unspecified number of additional shares of Common Stock is being registered as may be issued from time to time upon conversion of any Debt Securities that are convertible into Common Stock or pursuant to any anti-dilution adjustments with respect to any such convertible Debt Securities.

(2) Includes rights to acquire common stock or preferred stock of the Company under any shareholder rights plan then in effect, if applicable under the terms of any such plan.

(3) Estimated solely for the purpose of calculating the registration fee. No separate consideration will be received for shares of common stock that are issued upon conversion of debt securities, depositary shares or preferred stock or upon exercise of common stock warrants registered hereunder. The aggregate maximum offering price of all securities issued pursuant to this registration statement will not exceed $300,000,000 (including in connection with the offering, issuance and sale of up to $100,000,000 of the registrant’s common stock pursuant to this registration statement and a sales agreement, dated as of August 16, 2021, by and between the registrant and Cowen and Company LLC, or the Sales Agreement).

(4) Calculated pursuant to Rule 457(o) under the Securities Act.

(5) Pursuant to Rule 415(a)(6) under the Securities Act, this amount includes the registration fee of $10,910 previously paid in connection with the offering, issuance and sale of up to $100,000,000 of the registrant’s common stock pursuant to this registration statement and the Sales Agreement. The $300,000,000 of shares of common stock registered pursuant to this registration statement includes $100,000,000 of shares of common stock, or the Unsold Shares, registered pursuant to Registration Statement No. 333-258863 filed on August 16, 2021. Pursuant to Rule 415(a)(6) under the Securities Act of 1933, as amended, the filing fees previously paid in connection with the Unsold Shares will continue to be applied to the Unsold Shares.