<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created by RR Donnelley IM Processor 4.0.0.0 using Fujitsu Interstage XWand-->
<xbrl xmlns:gmost1="http://www.gmo.com/20120911" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dei="http://xbrl.sec.gov/dei/2012-01-31" xmlns:rr="http://xbrl.sec.gov/rr/2012-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.xbrl.org/2003/instance">
  <link:schemaRef xlink:type="simple" xlink:href="gmost1-20120911.xsd" />
  <context id="Duration_01Sep2011_31Aug2012">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0001521894</identifier>
    </entity>
    <period>
      <startDate>2011-09-01</startDate>
      <endDate>2012-08-31</endDate>
    </period>
  </context>
  <context id="Duration_01Sep2011_31Aug2012S000035217_Member">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0001521894</identifier>
      <segment>
        <xbrldi:explicitMember dimension="dei:LegalEntityAxis">gmost1:S000035217Member</xbrldi:explicitMember>
      </segment>
    </entity>
    <period>
      <startDate>2011-09-01</startDate>
      <endDate>2012-08-31</endDate>
    </period>
  </context>
  <dei:EntityRegistrantName contextRef="Duration_01Sep2011_31Aug2012">GMO Series Trust</dei:EntityRegistrantName>
  <dei:DocumentType contextRef="Duration_01Sep2011_31Aug2012">Other</dei:DocumentType>
  <dei:DocumentPeriodEndDate contextRef="Duration_01Sep2011_31Aug2012">2012-04-30</dei:DocumentPeriodEndDate>
  <dei:AmendmentFlag contextRef="Duration_01Sep2011_31Aug2012">false</dei:AmendmentFlag>
  <dei:DocumentCreationDate contextRef="Duration_01Sep2011_31Aug2012">2012-09-11</dei:DocumentCreationDate>
  <dei:EntityCentralIndexKey contextRef="Duration_01Sep2011_31Aug2012">0001521894</dei:EntityCentralIndexKey>
  <dei:DocumentEffectiveDate contextRef="Duration_01Sep2011_31Aug2012">2012-09-11</dei:DocumentEffectiveDate>
  <rr:ProspectusDate contextRef="Duration_01Sep2011_31Aug2012">2012-08-31</rr:ProspectusDate>
  <gmost1:SupplementTextBlock contextRef="Duration_01Sep2011_31Aug2012">&lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt;&lt;strong&gt;GMO SERIES TRUST &lt;/strong&gt; &lt;/p&gt; &lt;p&gt;&lt;/p&gt;&lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt;&lt;strong&gt;Supplement dated September 11, 2012 to &lt;/strong&gt; &lt;/p&gt;  &lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt; &lt;strong&gt;GMO Series Trust Prospectus and Statement of Additional Information, &lt;/strong&gt; &lt;/p&gt;  &lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt;&lt;strong&gt;each dated August 31, 2012 &lt;/strong&gt; &lt;/p&gt;&lt;p&gt; &lt;strong&gt;&lt;u&gt;GMO Global Asset Allocation Series Fund &lt;/u&gt;&lt;/strong&gt; &lt;/p&gt; &lt;p&gt; The reference to the benchmark of GMO Global Asset Allocation Series Fund that appears in the Average Annual Total Returns table on page 69 of the Prospectus is amended to "GMO Global Asset Allocation Index." &lt;/p&gt;</gmost1:SupplementTextBlock>
  <gmost1:SupplementTextBlock contextRef="Duration_01Sep2011_31Aug2012S000035217_Member">&lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt;&lt;strong&gt;GMO SERIES TRUST &lt;/strong&gt; &lt;/p&gt; &lt;p&gt;&lt;/p&gt;&lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt;&lt;strong&gt;Supplement dated September 11, 2012 to &lt;/strong&gt; &lt;/p&gt;  &lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt; &lt;strong&gt;GMO Series Trust Prospectus and Statement of Additional Information, &lt;/strong&gt; &lt;/p&gt;  &lt;p style="margin-top:0px; margin-bottom:0px" align="center"&gt;&lt;strong&gt;each dated August 31, 2012 &lt;/strong&gt; &lt;/p&gt;&lt;p&gt; &lt;strong&gt;&lt;u&gt;GMO Global Asset Allocation Series Fund &lt;/u&gt;&lt;/strong&gt; &lt;/p&gt; &lt;p&gt; The reference to the benchmark of GMO Global Asset Allocation Series Fund that appears in the Average Annual Total Returns table on page 69 of the Prospectus is amended to "GMO Global Asset Allocation Index." &lt;/p&gt;</gmost1:SupplementTextBlock>
</xbrl>
