EXHIBIT 21.1

List of Subsidiaries of Upland Software, Inc. as of December 31, 2015

Upland Software I, Inc. (f/k/a PowerSteering Software, Inc.)

Upland Software II, Inc. (f/k/a Tenrox Inc. (U.S.))

Upland Software III, LLC (f/k/a LMR Solutions LLC)

Upland Software IV, Inc. (f/k/a Filebound Solutions, Inc.)

Upland Software V, Inc. (f/k/a ComSci, Inc.)

Upland Software VI, LLC (f/k/a ComSci, LLC)

Upland Software VII, Inc. (f/k/a Clickability Inc.)

Upland IX, LLC (f/k/a Mobile Commons, Inc.)

Solution Q Inc.

Upland Software Inc. (f/k/a Tenrox Inc. (Canada))

PowerSteering Software Limited (UK)

Ultriva, Inc.