CHAPMAN AND CUTLER LLP                                 111 WEST MONROE STREET
                                                      CHICAGO, ILLINOIS 60603


                                 March 22, 2013


Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549

         Re:          First Trust Series Fund (the "Registrant")
                     (Registration Nos. 333-168727 and 811-22452)
                  -------------------------------------------------

 Ladies and Gentlemen:

      On behalf of First Trust Series Fund (the "Registrant"), we are
transmitting for electronic filing pursuant to Rule 497(e) under the Securities
Act of 1933, as amended, the exhibits containing interactive data format
risk/return summary information that mirrors the risk/return summary information
in the form of Supplement to the Prospectus and Statement of Additional
Information for the First Trust Preferred Securities and Income Fund and First
Trust/Confluence Small Cap Value Fund, each a series of the Registrant, filed
pursuant to Rule 497(e) on March 18, 2013.

      If you have any questions or comments, please telephone the undersigned at
(312) 845-3484.

                                                Very truly yours,

                                                CHAPMAN AND CUTLER LLP


                                                By: /s/ Morrison C. Warren
                                                    --------------------------
                                                        Morrison C. Warren
Enclosures