0001178913-21-001758.txt : 20210517
0001178913-21-001758.hdr.sgml : 20210517
20210517060149
ACCESSION NUMBER: 0001178913-21-001758
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20210331
FILED AS OF DATE: 20210517
DATE AS OF CHANGE: 20210517
EFFECTIVENESS DATE: 20210517
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 21927258
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
03-31-2021
03-31-2021
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
05-17-2021
2
170
1303789
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
890 5TH AVE PARTNERS INC
UNIT 01/12/2026
28250A204
983
98828
SH
DFND
98828
0
0
ABBVIE INC
COM
00287Y109
64878
599500
SH
DFND
1,2
599500
0
0
ACHILLES THERAPEUTICS PLC
SPONSORED ADS
00449L102
4965
300000
SH
DFND
1,2
300000
0
0
AFFIMED N V
COM
N01045108
8060
1018965
SH
DFND
1,2
1018965
0
0
AGILE GROWTH CORP
UNIT 03/09/2026
G01202129
496
50000
SH
DFND
50000
0
0
ALKURI GLOBAL ACQUISITION CO
UNIT 01/01/2028
66981N202
1482
150000
SH
DFND
150000
0
0
ALLOT LTD
SHS
M0854Q105
6711
420205
SH
DFND
420205
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
2102
198260
SH
DFND
1,2
198260
0
0
ALX ONCOLOGY HLDGS INC
COM
00166B105
9612
130351
SH
DFND
1,2
130351
0
0
AMAZON COM INC
COM
023135106
8543
2761
SH
DFND
2761
0
0
APOLLO STRATEGIC GROWTH CAPT
SHS CL A
G0411R106
1485
150000
SH
DFND
150000
0
0
ARGENX SE
SPONSORED ADR
04016X101
2547
9249
SH
DFND
1,2
9249
0
0
ARKO CORP
COM
041242108
4056
408000
SH
DFND
408000
0
0
ARYA SCIENCES ACQU CORP IV
CL A
G31659108
5200
500000
SH
DFND
1,2
500000
0
0
ARYA SCIENCES ACQUISITION CO
COM CL A
G3166W106
5512
400000
SH
DFND
1,2
400000
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
47755
960473
SH
DFND
1,2
960473
0
0
AUDIOCODES LTD
ORD
M15342104
12832
475624
SH
DFND
475624
0
0
BAIDU INC
SPON ADR REP A
056752108
5439
25000
SH
DFND
25000
0
0
BCLS ACQUISITION CORP
COM CL A
G0904B105
7271
687900
SH
DFND
1,2
687900
0
0
BEIGENE LTD
SPONSORED ADR
07725L102
7275
20900
SH
DFND
1,2
20900
0
0
BIOGEN INC
COM
09062X103
1902
6800
SH
DFND
1,2
6800
0
0
BOLT BIOTHERAPEUTICS INC
COM
097702104
7931
241000
SH
DFND
1,2
241000
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
1472
23890
SH
DFND
1,2
23890
0
0
BRISTOL-MYERS SQUIBB CO
COM
110122108
12626
200000
SH
DFND
1,2
200000
0
0
C4 THERAPEUTICS INC
COM STK
12529R107
18389
497136
SH
DFND
1,2
497136
0
0
CAESARSTONE LTD
ORD SHS
M20598104
7348
535148
SH
DFND
535148
0
0
CAMTEK LTD
ORD
M20791105
2384
79746
SH
DFND
79746
0
0
CATABASIS PHARMACEUTICALS IN
COM NEW
14875P206
3740
1294000
SH
DFND
1,2
1294000
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
4539
220320
SH
DFND
1,2
220320
0
0
CEREVEL THERAPEUTICS HLDNG I
*W EXP 06/09/202
15678U102
702
166332
SH
DFND
1,2
166332
0
0
CEREVEL THERAPEUTICS HLDNG I
COM
15678U128
12525
912240
SH
DFND
1,2
912240
0
0
CHINOOK THERAPEUTICS INC
COM
16961L106
1580
101666
SH
DFND
1,2
101666
0
0
CLARIM ACQUISITION CORP
UNIT 99/99/9999
18049C207
2985
300000
SH
DFND
300000
0
0
CM LIFE SCIENCES INC
COM CL A
18978W109
298
20000
SH
DFND
1,2
20000
0
0
CONNECT BIOPHARMA HLDGS LTD
ADS
207523101
925
50000
SH
DFND
1,2
50000
0
0
CRINETICS PHARMACEUTICALS IN
COM
22663K107
4343
284224
SH
DFND
1,2
284224
0
0
CURIS INC
COM NEW
231269200
10028
885838
SH
DFND
1,2
885838
0
0
CYBERARK SOFTWARE LTD
SHS
M2682V108
7114
55000
SH
DFND
55000
0
0
CYCLACEL PHARMACEUTICALS INC
COM
23254L603
3614
508322
SH
DFND
1,2
508322
0
0
DFP HEALTHCARE ACQUISITNS CO
COM CL A
23343Q100
1621
162759
SH
DFND
1,2
162759
0
0
DYNE THERAPEUTICS INC
COM
26818M108
6989
450064
SH
DFND
1,2
450064
0
0
E MERGE TECHNOLOGY ACQUISITI
COM CL A
26873Y104
975
100000
SH
DFND
100000
0
0
EDGEWISE THERAPEUTICS INC
COM
28036F105
3250
100000
SH
DFND
1,2
100000
0
0
EJF ACQUISITION CORP
UNIT 03/10/2026
G2955B117
497
49900
SH
DFND
49900
0
0
ENPHASE ENERGY INC
CALL
29355A107
37297
230000
SH
Call
DFND
0
0
230000
EQUILLIUM INC
COM
29446K106
1817
254184
SH
DFND
1,2
254184
0
0
ESSA PHARMA INC
COM NEW
29668H708
13631
469241
SH
DFND
1,2
469241
0
0
EUCRATES BIOMEDICAL ACQU COR
SHS
G3141W106
3007
304025
SH
DFND
1,2
304025
0
0
FALCON CAPITAL ACQUISITN COR
COM CL A
30606L108
997
100010
SH
DFND
100010
0
0
FARFETCH LTD
ORD SH CL A
30744W107
4242
80000
SH
DFND
80000
0
0
FATE THERAPEUTICS INC
COM
31189P102
9054
109807
SH
DFND
1,2
109807
0
0
FINCH THERAPEUTICS GROUP INC
COM
31773D101
2387
150000
SH
DFND
1,2
150000
0
0
FINTECH EVOLUTION ACQUIS GRO
UNIT 99/99/9999
G3R19A112
247
25000
SH
DFND
25000
0
0
FIVERR INTL LTD
CALL
M4R82T106
21718
100000
SH
Call
DFND
0
0
100000
FOLEY TRASIMENE ACQUISTN COR
COM CL A
34431F104
2008
200000
SH
DFND
200000
0
0
FORESIGHT ACQUISITION CORP
UNIT 01/29/2026
34552Y205
4162
420000
SH
DFND
420000
0
0
FORUM MERGER IV CORP
UNIT 03/15/2028
349875203
1485
150000
SH
DFND
150000
0
0
FRAZIER LIFESCIENCES ACQU CO
CL A SHS
G3710A105
1261
126687
SH
DFND
1,2
126687
0
0
GALECTO INC
COM
36322Q107
2722
448016
SH
DFND
1,2
448016
0
0
GALERA THERAPEUTICS INC
COM
36338D108
2852
323348
SH
DFND
1,2
323348
0
0
GAMIDA CELL LTD
SHS
M47364100
1444
178450
SH
DFND
1,2
178450
0
0
GENERAC HLDGS INC
COM
368736104
34599
105663
SH
DFND
105663
0
0
GIGCAPITAL4 INC
UNIT 99/99/9999
37518G200
1727
175000
SH
DFND
175000
0
0
GLASS HOUSES ACQUISITION COR
UNIT 03/25/2028
37714P202
902
89884
SH
DFND
89884
0
0
GLOBAL X FDS
PUT
37954Y442
4391
170600
SH
Put
DFND
170600
0
0
GRACELL BIOTECHNOLOGIES INC
SPONSORED ADS
38406L103
3274
212600
SH
DFND
1,2
212600
0
0
HEALTH SCIENCES ACQ CORP 2
ORD SHS
G4411D109
1123
100000
SH
DFND
1,2
100000
0
0
HEALTHCARE CAPITAL CORP
UNIT 12/31/2025
42228C200
3948
400000
SH
DFND
400000
0
0
HEALTHCOR CATALIO ACQU CORP
CL A SHS
G44125105
2000
200000
SH
DFND
1,2
200000
0
0
HIGHCAPE CAP ACQUISITION COR
COM CL A
42984L105
2055
172396
SH
DFND
1,2
172396
0
0
HIGHCAPE CAP ACQUISITION COR
CALL
42984L105
1013
85000
SH
Call
DFND
1,2
0
0
85000
I MAB
SPONSORED ADS
44975P103
2664
54962
SH
DFND
1,2
54962
0
0
IDEAYA BIOSCIENCES INC
COM
45166A102
4747
201984
SH
DFND
1,2
201984
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
295
100000
SH
DFND
1,2
100000
0
0
IMMUNOCORE HLDGS PLC
ADS
45258D105
1533
36000
SH
DFND
1,2
36000
0
0
IMMUNOVANT INC
COM
45258J102
2542
158500
SH
DFND
1,2
158500
0
0
INFLARX NV
COM
N44821101
3900
1000000
SH
DFND
1,2
1000000
0
0
INHIBRX INC
COM
45720L107
2301
114643
SH
DFND
1,2
114643
0
0
INSTIL BIO INC
COM
45783C101
2383
95000
SH
DFND
1,2
95000
0
0
IONIS PHARMACEUTICALS INC
COM
462222100
6541
145476
SH
DFND
1,2
145476
0
0
ISHARES TR
PUT
464287432
8127
60000
SH
Put
DFND
60000
0
0
ISHARES TR
PUT
464288224
10206
420000
SH
Put
DFND
420000
0
0
ISHARES TR
PUT
464287515
24207
70900
SH
Put
DFND
70900
0
0
ISHARES TR
PUT
464287655
46397
210000
SH
Put
DFND
210000
0
0
JIYA ACQUISITION CORP
COM CL A
47760M102
1958
199028
SH
DFND
1,2
199028
0
0
JOHNSON & JOHNSON
COM
478160104
74598
453900
SH
DFND
1,2
453900
0
0
JOHNSON & JOHNSON
CALL
478160104
32870
200000
SH
Call
DFND
1,2
0
0
200000
KALVISTA PHARMACEUTICALS INC
COM
483497103
6651
258880
SH
DFND
1,2
258880
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
14708
148381
SH
DFND
148381
0
0
KURA ONCOLOGY INC
COM
50127T109
20291
717751
SH
DFND
1,2
717751
0
0
KYMERA THERAPEUTICS INC
COM
501575104
9619
247527
SH
DFND
1,2
247527
0
0
LANDCADIA HOLDINGS IV INC
UNIT 05/01/2025
51477A203
1485
150000
SH
DFND
150000
0
0
LANDOS BIOPHARMA INC
COM
515069102
674
70000
SH
DFND
1,2
70000
0
0
LARIMAR THERAPEUTICS INC
COM
517125100
1461
100000
SH
DFND
1,2
100000
0
0
LAVA THERAPEUTICS NV
SHS
N51517105
3249
213894
SH
DFND
1,2
213894
0
0
LEFTERIS ACQUISITION CORP
COM CL A
52470X109
1181
120000
SH
DFND
120000
0
0
LIFESCI ACQUISITION II CORP
COM
53229E103
2474
244000
SH
DFND
1,2
244000
0
0
LILLY ELI & CO
COM
532457108
80183
429200
SH
DFND
1,2
429200
0
0
LIONHEART ACQUISITION CORP I
COM CL A
53625R104
982
100000
SH
DFND
100000
0
0
LIVE OAK MOBILITY ACQUISI CO
UNIT 03/01/2028
538126202
749
75000
SH
DFND
75000
0
0
LIVEPERSON INC
COM
538146101
13712
260000
SH
DFND
260000
0
0
LONGVIEW ACQUISITION CORP II
UNIT 99/99/9999
54319Q204
3012
300000
SH
DFND
1,2
300000
0
0
MCAP ACQUISITION CORP
UNIT 02/18/2030
55282T208
995
100000
SH
DFND
100000
0
0
MDH ACQUISITION CORP
UNIT 99/99/9999
55283P205
308
31000
SH
DFND
31000
0
0
MERCK & CO. INC
COM
58933Y105
62351
808808
SH
DFND
1,2
808808
0
0
MEREO BIOPHARMA GROUP PLC
ADS
589492107
4423
1312415
SH
DFND
1,2
1312415
0
0
MERUS N V
COM
N5749R100
1608
76992
SH
DFND
1,2
76992
0
0
MICROSOFT CORP
COM
594918104
15923
67536
SH
DFND
67536
0
0
MIRATI THERAPEUTICS INC
COM
60468T105
5101
29779
SH
DFND
1,2
29779
0
0
MOHAWK GROUP HLDGS INC
COM
608189106
7405
251015
SH
DFND
251015
0
0
MOHAWK GROUP HLDGS INC
CALL
608189106
10490
355600
SH
Call
DFND
0
0
355600
NEUBASE THERAPEUTICS INC
COM
64132K102
236
31900
SH
DFND
1,2
31900
0
0
NICE LTD
SPONSORED ADR
653656108
8606
39481
SH
DFND
39481
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
666
250000
SH
DFND
250000
0
0
NKARTA INC
COM
65487U108
3323
101006
SH
DFND
1,2
101006
0
0
NOBLE ROCK ACQUISITION CORP
UNIT 01/31/2028
G6546R127
277
28000
SH
DFND
28000
0
0
NORTHERN STAR INVSTMNT CORP
COM CLASS A
66573W107
1554
155367
SH
DFND
155367
0
0
NOVA MEASURING INSTRUMENTS L
COM
M7516K103
779
8556
SH
DFND
8556
0
0
NURIX THERAPEUTICS INC
COM
67080M103
6687
215076
SH
DFND
1,2
215076
0
0
OMEGA ALPHA SPAC
CL A
G6749V107
990
100000
SH
DFND
1,2
100000
0
0
ONCORUS INC
COM
68236R103
12571
903111
SH
DFND
1,2
903111
0
0
ONTO INNOVATION INC
COM
683344105
8214
125000
SH
DFND
125000
0
0
ORCHARD THERAPEUTICS PLC
ADS
68570P101
9921
1366564
SH
DFND
1,2
1366564
0
0
ORIC PHARMACEUTICALS INC
COM
68622P109
4163
169900
SH
DFND
1,2
169900
0
0
OUTLOOK THERAPEUTICS INC
*W EXP 02/18/202
69012T115
131
129500
SH
DFND
1,2
129500
0
0
PALO ALTO NETWORKS INC
COM
697435105
10403
32300
SH
DFND
32300
0
0
PERRIGO CO PLC
CALL
G97822103
8499
210000
SH
Call
DFND
0
0
210000
PHASEBIO PHARMACEUTICALS INC
COM
717224109
2595
750000
SH
DFND
1,2
750000
0
0
PIERIS PHARMACEUTICALS INC
COM
720795103
1671
650000
SH
DFND
1,2
650000
0
0
PMV PHARMACEUTICALS INC
COM
69353Y103
1426
43356
SH
DFND
1,2
43356
0
0
PROTAGONIST THERAPEUTICS INC
COM
74366E102
5235
202134
SH
DFND
1,2
202134
0
0
RADA ELECTR INDS LTD
COM PAR NEW
M81863124
4899
407925
SH
DFND
407925
0
0
REINVENT TECHNOLOGY PARTNERS
SHS CL A
G74847107
4685
468012
SH
DFND
468012
0
0
REPARE THERAPEUTICS INC
COM
760273102
7614
248100
SH
DFND
1,2
248100
0
0
RESEARCH ALLIANCE CORP II
COM CL A
760873109
6150
600000
SH
DFND
1,2
600000
0
0
REVOLUTION ACCELERTN ACQU CO
COM CL A
76156P106
1115
109994
SH
DFND
109994
0
0
SANOFI
SPONSORED ADR
80105N105
49356
997900
SH
DFND
1,2
997900
0
0
SARISSA CAPITAL ACQUISITN CO
CL A
G7823W102
242
23900
SH
DFND
1,2
23900
0
0
SHATTUCK LABS INC
COM
82024L103
4113
140665
SH
DFND
1,2
140665
0
0
SIGILON THERAPEUTICS INC
COM
82657L107
8072
362239
SH
DFND
1,2
362239
0
0
SILVERBACK THERAPEUTICS INC
COM
82835W108
7321
167799
SH
DFND
1,2
167799
0
0
SPARTAN ACQUISITION CORP II
COM
846775104
523
50000
SH
DFND
50000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
10129
137672
SH
DFND
1,2
137672
0
0
STARBOARD VALUE ACQUISITN CO
COM CL A
85521J109
1697
170937
SH
DFND
170937
0
0
STOKE THERAPEUTICS INC
COM
86150R107
5854
150729
SH
DFND
1,2
150729
0
0
STRATIM CLOUD ACQUISITION CO
UNIT 03/05/2026
86309R206
500
50000
SH
DFND
50000
0
0
SUTRO BIOPHARMA INC
COM
869367102
6710
294825
SH
DFND
1,2
294825
0
0
SWITCHBACK II CORPORATION
COM CL A
G8633T115
1019
103698
SH
DFND
103698
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
14268
638093
SH
DFND
1,2
638093
0
0
TAILWIND INTERNATNAL ACQ COR
UNIT 99/99/9999
G8662F127
1484
150000
SH
DFND
150000
0
0
TERNS PHARMACEUTICALS INC
COM
880881107
1540
70000
SH
DFND
1,2
70000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
9611
832878
SH
DFND
832878
0
0
TEVA PHARMACEUTICAL INDS LTD
CALL
881624209
10257
888800
SH
Call
DFND
0
0
888800
THERAPEUTICS ACQUISITION COR
COM CL A
88339T103
7567
720000
SH
DFND
1,2
720000
0
0
TRILLIUM THERAPEUTICS INC
COM NEW
89620X506
7201
670459
SH
DFND
1,2
670459
0
0
TURMERIC ACQUISITION CORP
CL A
G9127T108
2144
219440
SH
DFND
1,2
219440
0
0
UNUM THERAPEUTICS INC
COM
19240Q201
6695
762569
SH
DFND
1,2
762569
0
0
VARONIS SYS INC
COM
922280102
7120
138675
SH
DFND
138675
0
0
VECTOIQ ACQUISITION CORP II
UNIT 99/99/9999
92244F208
507
50000
SH
DFND
50000
0
0
VERONA PHARMA PLC
SPONSORED ADS
925050106
6699
801256
SH
DFND
1,2
801256
0
0
VERTEX PHARMACEUTICALS INC
COM
92532F100
1188
5530
SH
DFND
1,2
5530
0
0
VINCERX PHARMA INC
COM NEW
92731L106
1809
93708
SH
DFND
1,2
93708
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
8897
4177158
SH
DFND
1,2
4177158
0
0
VPC IMPACT ACQU HOLDI III IN
UNIT 99/99/9999
91835J207
987
100000
SH
DFND
100000
0
0
VPC IMPACT ACQUISITION HLDG
UNIT 03/05/2026
G9460L100
986
100000
SH
DFND
100000
0
0
WIX COM LTD
SHS
M98068105
1592
5700
SH
DFND
5700
0
0
YUMANITY THERAPEUTICS INC
COM
98872L102
3776
208609
SH
DFND
1,2
208609
0
0
ZAI LAB LTD
ADR
98887Q104
8778
65788
SH
DFND
1,2
65788
0
0
ZENTALIS PHARMACEUTICALS INC
COM
98943L107
7599
175140
SH
DFND
1,2
175140
0
0
Z-WORK ACQUISITION CORP
UNIT 99/99/9999
98880C201
498
50000
SH
DFND
50000
0
0