0001178913-21-000561.txt : 20210216
0001178913-21-000561.hdr.sgml : 20210216
20210216062902
ACCESSION NUMBER: 0001178913-21-000561
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20201231
FILED AS OF DATE: 20210216
DATE AS OF CHANGE: 20210216
EFFECTIVENESS DATE: 20210216
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 21632121
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
12-31-2020
12-31-2020
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
02-14-2021
2
110
1126784
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
89BIO INC
COM
282559103
1704
69939
SH
DFND
1,2
69939
0
0
ABBVIE INC
COM
00287Y109
36431
340000
SH
DFND
1,2
340000
0
0
ABBVIE INC
CALL
00287Y109
24109
225000
SH
Call
DFND
1,2
0
0
225000
ACLARIS THERAPEUTICS INC
COM
00461U105
971
150000
SH
DFND
1,2
150000
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
9374
60000
SH
DFND
1,2
60000
0
0
ALIGOS THERAPEUTICS INC
COM
01626L105
2046
74000
SH
DFND
1,2
74000
0
0
ALLOT LTD
SHS
M0854Q105
5609
533192
SH
DFND
533192
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
2498
198260
SH
DFND
1,2
198260
0
0
ALX ONCOLOGY HLDGS INC
COM
00166B105
11503
133448
SH
DFND
1,2
133448
0
0
AMAZON COM INC
COM
023135106
6713
2061
SH
DFND
2061
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
6136
265753
SH
DFND
1,2
265753
0
0
ARGENX SE
SPONSORED ADR
04016X101
2720
9249
SH
DFND
1,2
9249
0
0
ARKO CORP
COM
041242108
5400
600000
SH
DFND
600000
0
0
ARYA SCIENCES ACQUISITION CO
COM CL A
G3166W106
4340
400000
SH
DFND
1,2
400000
0
0
ASCENDIS PHARMA A/S
SPONSORED ADR
04351P101
3936
23599
SH
DFND
1,2
23599
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
34517
690473
SH
DFND
1,2
690473
0
0
ATHIRA PHARMA INC
COM
04746L104
1846
53900
SH
DFND
1,2
53900
0
0
AUDIOCODES LTD
ORD
M15342104
11818
428971
SH
DFND
428971
0
0
AVROBIO INC
COM
05455M100
9143
655874
SH
DFND
1,2
655874
0
0
BCLS ACQUISITION CORP
COM CL A
G0904B105
6891
625000
SH
DFND
1,2
625000
0
0
BEYONDSPRING INC
SHS
G10830100
7296
598000
SH
DFND
1,2
598000
0
0
BIOATLA INC
COM
09077B104
1701
50000
SH
DFND
1,2
50000
0
0
BIOXCEL THERAPEUTICS INC
COM
09075P105
1298
28093
SH
DFND
1,2
28093
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
11228
157900
SH
DFND
1,2
157900
0
0
BRISTOL-MYERS SQUIBB CO
COM
110122108
38769
625000
SH
DFND
1,2
625000
0
0
BURLINGTON STORES INC
COM
122017106
9154
35000
SH
DFND
35000
0
0
C4 THERAPEUTICS INC
COM STK
12529R107
14601
443824
SH
DFND
1,2
443824
0
0
CAMTEK LTD
ORD
M20791105
8764
400000
SH
DFND
400000
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
10463
597198
SH
DFND
1,2
597198
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
182
87500
SH
DFND
1,2
87500
0
0
CEREVEL THERAPEUTICS HLDNG I
*W EXP 06/09/202
15678U102
940
166332
SH
DFND
1,2
166332
0
0
CEREVEL THERAPEUTICS HLDNG I
COM
15678U128
13457
811665
SH
DFND
1,2
811665
0
0
CHINOOK THERAPEUTICS INC
COM
16961L106
3198
201666
SH
DFND
1,2
201666
0
0
COGENT BIOSCIENCES INC
COM
19240Q201
8259
735434
SH
DFND
1,2
735434
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
4854
384039
SH
DFND
1,2
384039
0
0
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
5910
103565
SH
DFND
1,2
103565
0
0
DICERNA PHARMACEUTICALS INC
COM
253031108
4780
216980
SH
DFND
1,2
216980
0
0
DYNE THERAPEUTICS INC
COM
26818M108
2100
100000
SH
DFND
1,2
100000
0
0
ESSA PHARMA INC
COM NEW
29668H708
4655
390200
SH
DFND
1,2
390200
0
0
FACEBOOK INC
CL A
30303M102
10926
39998
SH
DFND
39998
0
0
FATE THERAPEUTICS INC
COM
31189P102
7456
82000
SH
DFND
1,2
82000
0
0
GALECTO INC
COM
36322Q107
4669
391787
SH
DFND
1,2
391787
0
0
GALERA THERAPEUTICS INC
COM
36338D108
4784
467662
SH
DFND
1,2
467662
0
0
GAMIDA CELL LTD
SHS
M47364100
336
40000
SH
DFND
1,2
40000
0
0
GENERAC HLDGS INC
COM
368736104
24029
105663
SH
DFND
105663
0
0
HEALTH SCIENCES ACQ CORP 2
ORD SHS
G4411D109
1281
100000
SH
DFND
1,2
100000
0
0
I MAB
SPONSORED ADS
44975P103
8573
181820
SH
DFND
1,2
181820
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
288
100000
SH
DFND
1,2
100000
0
0
IMMATICS N.V
SHS
N44445109
8884
823391
SH
DFND
1,2
823391
0
0
IMMUNOVANT INC
COM
45258J102
7852
170000
SH
DFND
1,2
170000
0
0
INHIBRX INC
COM
45720L107
1424
43182
SH
DFND
1,2
43182
0
0
ION ACQUISITION CORP 1 LTD
SHS CL A
G49392106
1766
150000
SH
DFND
150000
0
0
IONIS PHARMACEUTICALS INC
COM
462222100
5190
91800
SH
DFND
1,2
91800
0
0
IOVANCE BIOTHERAPEUTICS INC
COM
462260100
5906
127289
SH
DFND
1,2
127289
0
0
JFROG LTD
ORD SHS
M6191J100
4547
72377
SH
DFND
72377
0
0
JOHNSON & JOHNSON
COM
478160104
53226
338200
SH
DFND
1,2
338200
0
0
KALVISTA PHARMACEUTICALS INC
COM
483497103
4560
240140
SH
DFND
1,2
240140
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
11443
128381
SH
DFND
128381
0
0
KRONOS BIO INC
COM
50107A104
1045
35000
SH
DFND
1,2
35000
0
0
KRYSTAL BIOTECH INC
COM
501147102
6063
101044
SH
DFND
1,2
101044
0
0
KURA ONCOLOGY INC
COM
50127T109
15399
471494
SH
DFND
1,2
471494
0
0
KYMERA THERAPEUTICS INC
COM
501575104
9157
147700
SH
DFND
1,2
147700
0
0
LEAP THERAPEUTICS INC
COM
52187K101
1800
800000
SH
DFND
1,2
800000
0
0
LIFESCI ACQUISITION II CORP
COM
53229E103
1062
100000
SH
DFND
1,2
100000
0
0
LILLY ELI & CO
COM
532457108
69224
410000
SH
DFND
1,2
410000
0
0
MERCK & CO. INC
COM
58933Y105
59616
728808
SH
DFND
1,2
728808
0
0
MERCK & CO. INC
CALL
58933Y105
10634
130000
SH
Call
DFND
1,2
0
0
130000
MICROSOFT CORP
COM
594918104
10573
47536
SH
DFND
47536
0
0
MIRAGEN THERAPEUTICS INC
COM
60463E103
502
30497
SH
DFND
1,2
30497
0
0
MIRATI THERAPEUTICS INC
COM
60468T105
6541
29779
SH
DFND
1,2
29779
0
0
NICE LTD
SPONSORED ADR
653656108
21118
74481
SH
DFND
74481
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
856
250000
SH
DFND
250000
0
0
NOVA MEASURING INSTRUMENTS L
COM
M7516K103
5515
78113
SH
DFND
78113
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
40510
429000
SH
DFND
1,2
429000
0
0
NOVARTIS AG
CALL
66987V109
11332
120000
SH
Call
DFND
1,2
0
0
120000
OLEMA PHARMACEUTICALS INC
COM
68062P106
731
15200
SH
DFND
1,2
15200
0
0
ONCORUS INC
COM
68236R103
28395
903111
SH
DFND
1,2
903111
0
0
ORGENESIS INC
COM NEW
68619K204
161
35712
SH
DFND
1,2
35712
0
0
ORIC PHARMACEUTICALS INC
COM
68622P109
6167
182200
SH
DFND
1,2
182200
0
0
OUTLOOK THERAPEUTICS INC
*W EXP 02/18/202
69012T115
29
129500
SH
DFND
1,2
129500
0
0
PALO ALTO NETWORKS INC
COM
697435105
13459
37871
SH
DFND
37871
0
0
PIERIS PHARMACEUTICALS INC
COM
720795103
1375
550000
SH
DFND
1,2
550000
0
0
PRAXIS PRECISION MEDICINES I
COM
74006W108
5502
100000
SH
DFND
1,2
100000
0
0
REPARE THERAPEUTICS INC
COM
760273102
7693
224300
SH
DFND
1,2
224300
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4113
75000
SH
DFND
1,2
75000
0
0
SAGE THERAPEUTICS INC
COM
78667J108
740
8554
SH
DFND
1,2
8554
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
12787
75000
SH
DFND
1,2
75000
0
0
SAREPTA THERAPEUTICS INC
PUT
803607100
12787
75000
SH
Put
DFND
1,2
75000
0
0
SAREPTA THERAPEUTICS INC
CALL
803607100
63081
370000
SH
Call
DFND
1,2
0
0
370000
SHATTUCK LABS INC
COM
82024L103
2898
55300
SH
DFND
1,2
55300
0
0
SIGILON THERAPEUTICS INC
COM
82657L107
26061
567460
SH
DFND
1,2
567460
0
0
SILVERBACK THERAPEUTICS INC
COM
82835W108
8075
174261
SH
DFND
1,2
174261
0
0
SPDR SER TR
PUT
78464A870
42234
300000
SH
Put
DFND
1,2
300000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
2270
31300
SH
DFND
1,2
31300
0
0
SUTRO BIOPHARMA INC
COM
869367102
4377
201600
SH
DFND
1,2
201600
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
16589
745900
SH
DFND
1,2
745900
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
8037
832878
SH
DFND
832878
0
0
THERAPEUTICS ACQUISITION COR
COM CL A
88339T103
279
20000
SH
DFND
1,2
20000
0
0
TRILLIUM THERAPEUTICS INC
COM NEW
89620X506
9220
626759
SH
DFND
1,2
626759
0
0
UNIQURE NV
SHS
N90064101
7804
216000
SH
DFND
1,2
216000
0
0
VARONIS SYS INC
COM
922280102
9035
55225
SH
DFND
55225
0
0
VERINT SYS INC
COM
92343X100
8532
127000
SH
DFND
127000
0
0
VERONA PHARMA PLC
SPONSORED ADS
925050106
7235
1033603
SH
DFND
1,2
1033603
0
0
VINCERA PHARMA INC
COM
92731L106
972
46465
SH
DFND
1,2
46465
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
5287
2725000
SH
DFND
1,2
2725000
0
0
WAVE LIFE SCIENCES LTD
SHS
Y95308105
3266
414959
SH
DFND
1,2
414959
0
0
Y-MABS THERAPEUTICS INC
COM
984241109
6487
131016
SH
DFND
1,2
131016
0
0
YUMANITY THERAPEUTICS INC
COM
98872L102
2217
130434
SH
DFND
1,2
130434
0
0
ZENTALIS PHARMACEUTICALS INC
COM
98943L107
9910
190796
SH
DFND
1,2
190796
0
0
ZYMEWORKS INC
COM
98985W102
11579
245000
SH
DFND
1,2
245000
0
0