0001178913-20-001462.txt : 20200514
0001178913-20-001462.hdr.sgml : 20200514
20200514074912
ACCESSION NUMBER: 0001178913-20-001462
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20200331
FILED AS OF DATE: 20200514
DATE AS OF CHANGE: 20200514
EFFECTIVENESS DATE: 20200514
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 20875313
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
03-31-2020
03-31-2020
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
05-10-2020
2
78
799546
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ABBVIE INC
COM
00287Y109
12571
165000
SH
DFND
1,2
165000
0
0
ACADIA PHARMACEUTICALS INC
COM
004225108
6633
157000
SH
DFND
1,2
157000
0
0
ADMA BIOLOGICS INC
COM
000899104
5294
1838100
SH
DFND
1,2
1838100
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
2641
1069089
SH
DFND
1,2
1069089
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
22393
249396
SH
DFND
1,2
249396
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
643
667800
SH
DFND
1,2
667800
0
0
ALLOT LTD
SHS
M0854Q105
8650
915302
SH
DFND
915302
0
0
AMAZON COM INC
COM
023135106
10275
5270
SH
DFND
5270
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
18643
2017624
SH
DFND
1,2
2017624
0
0
APPLIED THERAPEUTICS INC
COM
03828A101
2222
67967
SH
DFND
1,2
67967
0
0
APTINYX INC
COM
03836N103
889
411666
SH
DFND
1,2
411666
0
0
ARGENX SE
SPONSORED ADR
04016X101
1352
10265
SH
DFND
1,2
10265
0
0
ARVINAS INC
COM
04335A105
5875
145781
SH
DFND
1,2
145781
0
0
ARYA SCIENCES ACQUISITION CO
UNIT 10/04/2023
G3165V117
2258
200000
SH
DFND
1,2
200000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
3668
32573
SH
DFND
1,2
32573
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
25456
570000
SH
DFND
1,2
570000
0
0
AUDIOCODES LTD
ORD
M15342104
4936
206619
SH
DFND
206619
0
0
AXOVANT GENE THERAPIES LTD
COM
G0750W203
7152
2931018
SH
DFND
1,2
2931018
0
0
BEAM THERAPEUTICS INC
COM
07373V105
4764
264681
SH
DFND
1,2
264681
0
0
BLUEPRINT MEDICINES CORP
COM
09627Y109
6404
109500
SH
DFND
1,2
109500
0
0
BRISTOL-MYERS SQUIBB CO
RIGHT 99/99/9999
110122157
190
50000
SH
DFND
1,2
50000
0
0
BRISTOL-MYERS SQUIBB CO
COM
110122108
43477
780000
SH
DFND
1,2
780000
0
0
CASSAVA SCIENCES INC
COM
14817C107
2528
615000
SH
DFND
1,2
615000
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
111
87500
SH
DFND
1,2
87500
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
8955
1013039
SH
DFND
1,2
1013039
0
0
CYCLERION THERAPEUTICS INC
COM
23255M105
331
124976
SH
DFND
1,2
124976
0
0
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
4920
119500
SH
DFND
1,2
119500
0
0
EVOLUS INC
COM
30052C107
2283
550000
SH
DFND
1,2
550000
0
0
EXICURE INC
COM
30205M101
4861
3284795
SH
DFND
1,2
3284795
0
0
FIVERR INTL LTD
ORD SHS
M4R82T106
2639
104839
SH
DFND
104839
0
0
GALERA THERAPEUTICS INC
COM
36338D108
4519
475677
SH
DFND
1,2
475677
0
0
GLOBAL BLOOD THERAPEUTICS IN
COM
37890U108
1265
24752
SH
DFND
1,2
24752
0
0
IMMUNOVANT INC
COM
45258J102
296
19032
SH
DFND
1,2
19032
0
0
IMMUNOVANT INC
UNIT 12/18/2024
45258J201
1564
94500
SH
DFND
1,2
94500
0
0
ISHARES TR
PUT
464287655
103014
900000
SH
Put
DFND
1,2
0
0
900000
IVERIC BIO INC
COM
46583P102
425
123424
SH
DFND
1,2
123424
0
0
JOHNSON & JOHNSON
COM
478160104
45719
348653
SH
DFND
1,2
348653
0
0
KALVISTA PHARMACEUTICALS INC
COM
483497103
1837
240140
SH
DFND
1,2
240140
0
0
KARYOPHARM THERAPEUTICS INC
COM
48576U106
10566
550000
SH
DFND
1,2
550000
0
0
LEAP THERAPEUTICS INC
COM
52187K101
948
600000
SH
DFND
1,2
600000
0
0
MERCK & CO. INC
COM
58933Y105
66824
868518
SH
DFND
1,2
868518
0
0
MICROSOFT CORP
COM
594918104
14819
93964
SH
DFND
93964
0
0
MILESTONE PHARMACEUTICALS IN
COM
59935V107
125
67992
SH
DFND
1,2
67992
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
1014
168357
SH
DFND
1,2
168357
0
0
NEOLEUKIN THERAPEUTICS INC
COM
64049K104
4518
397000
SH
DFND
1,2
397000
0
0
NEOS THERAPEUTICS INC
COM
64052L106
1882
2509468
SH
DFND
1,2
2509468
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
445
250000
SH
DFND
250000
0
0
NOVARTIS A G
SPONSORED ADR
66987V109
11543
140000
SH
DFND
1,2
140000
0
0
NOVO-NORDISK A S
ADR
670100205
34675
576000
SH
DFND
1,2
576000
0
0
ORGENESIS INC
COM NEW
68619K204
4216
1109564
SH
DFND
1,2
1109564
0
0
OUTLOOK THERAPEUTICS INC
*W EXP 02/18/202
69012T115
130
129500
SH
DFND
1,2
0
0
129500
PALO ALTO NETWORKS INC
COM
697435105
2697
16452
SH
DFND
16452
0
0
PASSAGE BIO INC
COM
702712100
7135
478171
SH
DFND
1,2
478171
0
0
PFIZER INC
COM
717081103
17952
550000
SH
DFND
1,2
550000
0
0
PRECISION BIOSCIENCES INC
COM
74019P108
889
147352
SH
DFND
1,2
147352
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
1900
346148
SH
DFND
1,2
346148
0
0
PROTAGONIST THERAPEUTICS INC
COM
74366E102
3714
526075
SH
DFND
1,2
526075
0
0
PROTEOSTASIS THERAPEUTICS IN
COM
74373B109
2892
2536600
SH
DFND
1,2
2536600
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4673
335016
SH
DFND
1,2
335016
0
0
SALESFORCE COM INC
COM
79466L302
5115
35529
SH
DFND
35529
0
0
SANOFI
SPONSORED ADR
80105N105
42408
970000
SH
DFND
1,2
970000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
25238
258000
SH
DFND
1,2
258000
0
0
SELECT SECTOR SPDR TR
SBI CONS STPLS
81369Y308
7909
145207
SH
DFND
145207
0
0
SPDR S&P 500 ETF TR
PUT
78462F103
54102
209900
SH
Put
DFND
0
0
209900
SPDR SER TR
PUT
78464A870
38720
500000
SH
Put
DFND
1,2
0
0
500000
STOKE THERAPEUTICS INC
COM
86150R107
624
27254
SH
DFND
1,2
27254
0
0
SUNESIS PHARMACEUTICALS INC
COM
867328700
299
721800
SH
DFND
1,2
721800
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
747
68134
SH
DFND
1,2
68134
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
3203
356713
SH
DFND
356713
0
0
TRILLIUM THERAPEUTICS INC
COM NEW
89620X506
5093
1260694
SH
DFND
1,2
1260694
0
0
UNIQURE NV
SHS
N90064101
9543
201107
SH
DFND
1,2
201107
0
0
VERTEX PHARMACEUTICALS INC
COM
92532F100
1666
7000
SH
DFND
1,2
7000
0
0
VIKING THERAPEUTICS INC
COM
92686J106
2761
590000
SH
DFND
1,2
590000
0
0
X4 PHARMACEUTICALS INC
COM
98420X103
8732
873215
SH
DFND
1,2
873215
0
0
Y-MABS THERAPEUTICS INC
COM
984241109
8023
307379
SH
DFND
1,2
307379
0
0
ZAFGEN INC
COM
98885E103
2434
3161562
SH
DFND
1,2
3161562
0
0
ZYMEWORKS INC
COM
98985W102
7336
206830
SH
DFND
1,2
206830
0
0
ZYNERBA PHARMACEUTICALS INC
COM
98986X109
383
100000
SH
DFND
1,2
100000
0
0