0001178913-20-000447.txt : 20200213
0001178913-20-000447.hdr.sgml : 20200213
20200213121157
ACCESSION NUMBER: 0001178913-20-000447
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20191231
FILED AS OF DATE: 20200213
DATE AS OF CHANGE: 20200213
EFFECTIVENESS DATE: 20200213
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 20608270
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
12-31-2019
12-31-2019
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
02-09-2020
2
86
1213436
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ABEONA THERAPEUTICS INC
COM
00289Y107
2356
720472
SH
DFND
1,2
720472
0
0
ACADIA PHARMACEUTICALS INC
COM
004225108
15272
357000
SH
DFND
1,2
357000
0
0
ADMA BIOLOGICS INC
COM
000899104
2160
540000
SH
DFND
1,2
540000
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
6211
1069089
SH
DFND
1,2
1069089
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
12514
115713
SH
DFND
1,2
115713
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
2506
917800
SH
DFND
1,2
917800
0
0
ALLOT LTD
SHS
M0854Q105
8251
970666
SH
DFND
970666
0
0
AMAZON COM INC
COM
023135106
6837
3700
SH
DFND
3700
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
27275
2800320
SH
DFND
1,2
2800320
0
0
ARGENX SE
SPONSORED ADR
04016X101
2662
16581
SH
DFND
1,2
16581
0
0
ARQULE INC
COM
04269E107
5933
297227
SH
DFND
1,2
297227
0
0
ARVINAS INC
COM
04335A105
8168
198781
SH
DFND
1,2
198781
0
0
ARYA SCIENCES ACQUISITION CO
UNIT 10/04/2023
G3165V117
2300
200000
SH
DFND
1,2
200000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
10263
73773
SH
DFND
1,2
73773
0
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
1806
88248
SH
DFND
1,2
88248
0
0
AUDIOCODES LTD
ORD
M15342104
7863
306053
SH
DFND
306053
0
0
AXOVANT GENE THERAPIES LTD
COM
G0750W203
2041
398541
SH
DFND
1,2
398541
0
0
BELLICUM PHARMACEUTICALS INC
COM
079481107
516
400000
SH
DFND
1,2
400000
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
21254
251382
SH
DFND
1,2
251382
0
0
BLUEBIRD BIO INC
COM
09609G100
5660
64500
SH
DFND
1,2
64500
0
0
BLUEPRINT MEDICINES CORP
COM
09627Y109
8492
106000
SH
DFND
1,2
106000
0
0
BRISTOL MYERS SQUIBB CO
COM
110122108
58734
915000
SH
DFND
1,2
915000
0
0
BURLINGTON STORES INC
COM
122017106
4447
19500
SH
DFND
19500
0
0
CAESARSTONE LTD
ORD SHS
M20598104
5340
354357
SH
DFND
354357
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
197
87500
SH
DFND
1,2
87500
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
1292
140000
SH
DFND
1,2
140000
0
0
CYTOKINETICS INC
COM NEW
23282W605
2851
268747
SH
DFND
1,2
268747
0
0
EVOLUS INC
COM
30052C107
1826
150000
SH
DFND
1,2
150000
0
0
EXICURE INC
COM
30205M101
8262
2888888
SH
DFND
1,2
2888888
0
0
FISERV INC
COM
337738108
7779
67279
SH
DFND
67279
0
0
FIVERR INTL LTD
ORD SHS
M4R82T106
5494
233805
SH
DFND
233805
0
0
FORESCOUT TECHNOLOGIES INC
COM
34553D101
4494
137021
SH
DFND
137021
0
0
GALERA THERAPEUTICS INC
COM
36338D108
6204
471439
SH
DFND
1,2
471439
0
0
GILEAD SCIENCES INC
CALL
375558103
32490
500000
SH
Call
DFND
1,2
0
0
0
GW PHARMACEUTICALS PLC
ADS
36197T103
8051
77000
SH
DFND
1,2
77000
0
0
HARPOON THERAPEUTICS INC
COM
41358P106
5680
384031
SH
DFND
1,2
384031
0
0
IMMUNOVANT INC
COM
45258J102
317
20000
SH
DFND
1,2
20000
0
0
IMMUNOVANT INC
UNIT 12/18/2024
45258J201
2487
100000
SH
DFND
1,2
100000
0
0
INFLARX NV
COM
N44821101
1307
330000
SH
DFND
1,2
330000
0
0
ISHARES TR
PUT
464287556
120510
1000000
SH
Put
DFND
1,2
1000000
0
0
IVERIC BIO INC
COM
46583P102
7449
868200
SH
DFND
1,2
868200
0
0
JOHNSON & JOHNSON
COM
478160104
63986
438653
SH
DFND
1,2
438653
0
0
KALVISTA PHARMACEUTICALS INC
COM
483497103
2631
147700
SH
DFND
1,2
147700
0
0
KARYOPHARM THERAPEUTICS INC
COM
48576U106
6326
330000
SH
DFND
1,2
330000
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
3483
101759
SH
DFND
101759
0
0
KRYSTAL BIOTECH INC
COM
501147102
4778
86280
SH
DFND
1,2
86280
0
0
MELLANOX TECHNOLOGIES LTD
SHS
M51363113
990
8452
SH
DFND
8452
0
0
MERCK & CO INC
COM
58933Y105
50477
555000
SH
DFND
1,2
555000
0
0
MICROSOFT CORP
COM
594918104
9263
58741
SH
DFND
58741
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
6079
855000
SH
DFND
1,2
855000
0
0
MYLAN N V
SHS EURO
N59465109
11256
560000
SH
DFND
1,2
560000
0
0
NEOLEUKIN THERAPEUTICS INC
COM
64049K104
4682
379998
SH
DFND
1,2
379998
0
0
NEOS THERAPEUTICS INC
COM
64052L106
5331
3530731
SH
DFND
1,2
3530731
0
0
NOVA MEASURING INSTRUMENTS L
COM
M7516K103
3460
91466
SH
DFND
91466
0
0
NOVARTIS A G
SPONSORED ADR
66987V109
18938
200000
SH
DFND
1,2
200000
0
0
NOVO-NORDISK A S
ADR
670100205
37043
640000
SH
DFND
1,2
640000
0
0
PALO ALTO NETWORKS INC
COM
697435105
7163
30976
SH
DFND
30976
0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
7570
317000
SH
DFND
1,2
317000
0
0
PRECISION BIOSCIENCES INC
COM
74019P108
6858
493739
SH
DFND
1,2
493739
0
0
PRINCIPIA BIOPHARMA INC
COM
74257L108
4738
86500
SH
DFND
1,2
86500
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
7978
805000
SH
DFND
1,2
805000
0
0
PROTAGONIST THERAPEUTICS INC
COM
74366E102
4442
630000
SH
DFND
1,2
630000
0
0
PROTEOSTASIS THERAPEUTICS IN
COM
74373B109
5783
2536600
SH
DFND
1,2
2536600
0
0
PTC THERAPEUTICS INC
COM
69366J200
10314
214736
SH
DFND
1,2
214736
0
0
RETROPHIN INC
COM
761299106
4507
317381
SH
DFND
1,2
317381
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
8237
361888
SH
DFND
1,2
361888
0
0
SANOFI
SPONSORED ADR
80105N105
57228
1140000
SH
DFND
1,2
1140000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
18066
140000
SH
DFND
1,2
140000
0
0
SEATTLE GENETICS INC
CALL
812578102
28565
250000
SH
Call
DFND
1,2
0
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
5403
56822
SH
DFND
56822
0
0
SPDR SERIES TRUST
PUT
78464A870
266308
2800000
SH
Put
DFND
1,2
2800000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
7698
200000
SH
DFND
1,2
200000
0
0
STOKE THERAPEUTICS INC
COM
86150R107
7261
256380
SH
DFND
1,2
256380
0
0
SUNESIS PHARMACEUTICALS INC
COM
867328700
723
2141800
SH
DFND
1,2
2141800
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
2551
260352
SH
DFND
260352
0
0
TEVA PHARMACEUTICAL INDS LTD
CALL
881624209
11962
1220600
SH
Call
DFND
0
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
4912
115000
SH
DFND
1,2
115000
0
0
UNIQURE NV
SHS
N90064101
9998
139514
SH
DFND
1,2
139514
0
0
VERINT SYS INC
COM
92343X100
16093
290699
SH
DFND
290699
0
0
VIKING THERAPEUTICS INC
COM
92686J106
4732
590000
SH
DFND
1,2
590000
0
0
WABTEC CORP
COM
929740108
3112
40000
SH
DFND
40000
0
0
WIX COM LTD
SHS
M98068105
5068
41415
SH
DFND
41415
0
0
X4 PHARMACEUTICALS INC
COM
98420X103
7704
720000
SH
DFND
1,2
720000
0
0
Y MABS THERAPEUTICS INC
COM
984241109
6665
213293
SH
DFND
1,2
213293
0
0
ZAFGEN INC
COM
98885E103
386
347670
SH
DFND
1,2
347670
0
0
ZYMEWORKS INC
COM
98985W102
7137
157000
SH
DFND
1,2
157000
0
0