0001178913-19-002713.txt : 20191114
0001178913-19-002713.hdr.sgml : 20191114
20191114060130
ACCESSION NUMBER: 0001178913-19-002713
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20190930
FILED AS OF DATE: 20191114
DATE AS OF CHANGE: 20191114
EFFECTIVENESS DATE: 20191114
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 191216113
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
09-30-2019
09-30-2019
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Ori Goldfarb
Chief Executive Officer
972-3-6845535
/s/ Ori Goldfarb
Tel Aviv
L3
11-13-2019
2
80
647319
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ACADIA PHARMACEUTICALS INC
COM
004225108
3239
90000
SH
DFND
1,2
90000
0
0
AKERO THERAPEUTICS INC
COM
00973Y108
2958
130000
SH
DFND
1,2
130000
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
5634
1069089
SH
DFND
1,2
1069089
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
16230
165713
SH
DFND
1,2
165713
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
2655
673881
SH
DFND
1,2
673881
0
0
ALLOT LTD
SHS
M0854Q105
5328
661031
SH
DFND
661031
0
0
AMAZON COM INC
COM
023135106
3819
2200
SH
DFND
2200
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
23501
2930320
SH
DFND
1,2
2930320
0
0
ARBUTUS BIOPHARMA CORP
COM
03879J100
763
500000
SH
DFND
1,2
500000
0
0
ARGENX SE
SPONSORED ADR
04016X101
4397
38581
SH
DFND
1,2
38581
0
0
ARQULE INC
COM
04269E107
14933
2082643
SH
DFND
1,2
2082643
0
0
ARVINAS INC
COM
04335A105
4424
205281
SH
DFND
1,2
205281
0
0
ARYA SCIENCES ACQUISITION CO
UNIT 10/04/2023
G3165V117
2188
200000
SH
DFND
1,2
200000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
7106
73773
SH
DFND
1,2
73773
0
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
1180
120000
SH
DFND
1,2
120000
0
0
AUDIOCODES LTD
ORD
M15342104
6207
328263
SH
DFND
328263
0
0
AVROBIO INC
COM
05455M100
1784
126324
SH
DFND
1,2
126324
0
0
AXOVANT GENE THERAPIES LTD
COM
G0750W203
4319
668541
SH
DFND
1,2
668541
0
0
BELLICUM PHARMACEUTICALS INC
COM
079481107
788
750000
SH
DFND
1,2
750000
0
0
BLUEPRINT MEDICINES CORP
COM
09627Y109
3122
42500
SH
DFND
1,2
42500
0
0
BRISTOL MYERS SQUIBB CO
COM
110122108
56283
1109900
SH
DFND
1,2
1109900
0
0
BURLINGTON STORES INC
COM
122017106
3896
19500
SH
DFND
19500
0
0
CAESARSTONE LTD
ORD SHS
M20598104
7666
461509
SH
DFND
461509
0
0
CELGENE CORP
COM
151020104
24825
250000
SH
DFND
1,2
250000
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
175
87500
SH
DFND
1,2
87500
0
0
CHARTER COMMUNICATIONS INC N
CL A
16119P108
2473
6000
SH
DFND
6000
0
0
CHIASMA INC
COM
16706W102
4901
990000
SH
DFND
1,2
990000
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
823
140000
SH
DFND
1,2
140000
0
0
CUE BIOPHARMA INC
COM
22978P106
422
50000
SH
DFND
1,2
50000
0
0
DELEK US HLDGS INC NEW
COM
24665A103
1815
50000
SH
DFND
50000
0
0
DICERNA PHARMACEUTICALS INC
COM
253031108
8113
565000
SH
DFND
1,2
565000
0
0
ERYTECH PHARMA
SPONSORED ADR
29604W108
523
117837
SH
DFND
1,2
117837
0
0
EXICURE INC
COM
30205M101
6674
2637988
SH
DFND
1,2
2637988
0
0
FISERV INC
COM
337738108
6969
67279
SH
DFND
67279
0
0
FIVERR INTL LTD
ORD SHS
M4R82T106
2643
141355
SH
DFND
141355
0
0
FORESCOUT TECHNOLOGIES INC
COM
34553D101
6587
173696
SH
DFND
173696
0
0
GILEAD SCIENCES INC
COM
375558103
12993
205000
SH
DFND
1,2
205000
0
0
GILEAD SCIENCES INC
CALL
375558103
31690
500000
SH
DFND
1,2
0
0
0
GW PHARMACEUTICALS PLC
ADS
36197T103
8512
74000
SH
DFND
1,2
74000
0
0
HARPOON THERAPEUTICS INC
COM
41358P106
5109
374031
SH
DFND
1,2
374031
0
0
HEALTH SCIENCES ACQUSTN CORP
UNIT 04/01/2024
42227C201
1073
100000
SH
DFND
1,2
100000
0
0
ITURAN LOCATION AND CONTROL
SHS
M6158M104
3354
135311
SH
DFND
135311
0
0
JOHNSON & JOHNSON
COM
478160104
51752
400000
SH
DFND
1,2
400000
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
4050
131588
SH
DFND
131588
0
0
KRYSTAL BIOTECH INC
COM
501147102
4085
117625
SH
DFND
1,2
117625
0
0
MELLANOX TECHNOLOGIES LTD
SHS
M51363113
8425
76875
SH
DFND
76875
0
0
MERCK & CO INC
COM
58933Y105
39565
470000
SH
DFND
1,2
470000
0
0
MERSANA THERAPEUTICS INC
COM
59045L106
316
200000
SH
DFND
1,2
200000
0
0
MICROSOFT CORP
COM
594918104
7472
53741
SH
DFND
53741
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
5906
762018
SH
DFND
1,2
762018
0
0
NEOS THERAPEUTICS INC
COM
64052L106
5784
3908265
SH
DFND
1,2
3908265
0
0
NICE LTD
SPONSORED ADR
653656108
8224
57193
SH
DFND
57193
0
0
NOVA MEASURING INSTRUMENTS L
COM
M7516K103
1650
51949
SH
DFND
51949
0
0
NOVO-NORDISK A S
ADR
670100205
23265
450000
SH
DFND
1,2
450000
0
0
PALO ALTO NETWORKS INC
COM
697435105
6721
32976
SH
DFND
32976
0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
6973
260000
SH
DFND
1,2
260000
0
0
PRECISION BIOSCIENCES INC
COM
74019P108
3062
365000
SH
DFND
1,2
365000
0
0
PREVAIL THERAPEUTICS INC
COM
74140Y101
1108
90217
SH
DFND
1,2
90217
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
5270
915000
SH
DFND
1,2
915000
0
0
PTC THERAPEUTICS INC
COM
69366J200
10484
310000
SH
DFND
1,2
310000
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
5080
63269
SH
DFND
1,2
63269
0
0
RETROPHIN INC
COM
761299106
3827
330203
SH
DFND
1,2
330203
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
7689
660000
SH
DFND
1,2
660000
0
0
SANOFI
SPONSORED ADR
80105N105
32431
700000
SH
DFND
1,2
700000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
18682
248038
SH
DFND
1,2
248038
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
5358
64002
SH
DFND
64002
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
6721
310000
SH
DFND
1,2
310000
0
0
STOKE THERAPEUTICS INC
COM
86150R107
7384
346380
SH
DFND
1,2
346380
0
0
SUNESIS PHARMACEUTICALS INC
COM
867328700
1542
2141800
SH
DFND
1,2
2141800
0
0
SUTRO BIOPHARMA INC
COM
869367102
3841
422589
SH
DFND
1,2
422589
0
0
TEVA PHARMACEUTICAL INDS LTD
CALL
881624209
10664
1550000
SH
DFND
0
0
0
TUFIN SOFTWARE TECHNOLOGIS L
SHS
M8893U102
201
12231
SH
DFND
12231
0
0
UNIQURE NV
SHS
N90064101
6986
177500
SH
DFND
1,2
177500
0
0
UROGEN PHARMA LTD
COM
M96088105
8003
335817
SH
DFND
1,2
335817
0
0
VERINT SYS INC
COM
92343X100
5753
134489
SH
DFND
134489
0
0
WABTEC CORP
COM
929740108
2874
40000
SH
DFND
40000
0
0
WIX COM LTD
SHS
M98068105
4307
36890
SH
DFND
36890
0
0
X4 PHARMACEUTICALS INC
COM
98420X103
602
47391
SH
DFND
1,2
47391
0
0
Y MABS THERAPEUTICS INC
COM
984241109
4951
190000
SH
DFND
1,2
190000
0
0
ZYMEWORKS INC
COM
98985W102
4216
170000
SH
DFND
1,2
170000
0
0