0001178913-19-002162.txt : 20190814
0001178913-19-002162.hdr.sgml : 20190814
20190814060215
ACCESSION NUMBER: 0001178913-19-002162
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20190630
FILED AS OF DATE: 20190814
DATE AS OF CHANGE: 20190814
EFFECTIVENESS DATE: 20190814
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 191022637
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
06-30-2019
06-30-2019
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
08-07-2019
2
90
730995
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ADVANCE AUTO PARTS INC
COM
00751Y106
2682
17400
SH
DFND
17400
0
0
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
1282
187206
SH
DFND
1,2
187206
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
6415
1069089
SH
DFND
1,2
1069089
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
44114
336800
SH
DFND
1,2
336800
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
1999
491193
SH
DFND
1,2
491193
0
0
ALLOT LTD
SHS
M0854Q105
4766
661031
SH
DFND
661031
0
0
AMAZON COM INC
COM
023135106
7953
4200
SH
DFND
4200
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
31329
2510320
SH
DFND
1,2
2510320
0
0
ARBUTUS BIOPHARMA CORP
COM
03879J100
1040
500000
SH
DFND
1,2
500000
0
0
ARGENX SE
SPONSORED ADR
04016X101
5462
38581
SH
DFND
1,2
38581
0
0
ARQULE INC
COM
04269E107
19627
1782643
SH
DFND
1,2
1782643
0
0
ARVINAS INC
COM
04335A105
4514
205281
SH
DFND
1,2
205281
0
0
ARYA SCIENCES ACQUISITION CO
UNIT 10/04/2023
G3165V117
2138
200000
SH
DFND
1,2
200000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
8495
73773
SH
DFND
1,2
73773
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
31786
770000
SH
DFND
1,2
770000
0
0
AUDIOCODES LTD
ORD
M15342104
7062
456222
SH
DFND
456222
0
0
AUTOLUS THERAPEUTICS PLC
SPON ADS
05280R100
2858
177546
SH
DFND
1,2
177546
0
0
AXOVANT GENE THERAPIES LTD
COM
G0750W203
4165
668541
SH
DFND
1,2
668541
0
0
BENITEC BIOPHARMA LTD
SPONS ADR NEW
082053307
30
40000
SH
DFND
1,2
40000
0
0
BLUEBIRD BIO INC
COM
09609G100
9540
75000
SH
DFND
1,2
75000
0
0
BRISTOL MYERS SQUIBB CO
COM
110122108
42171
929900
SH
DFND
1,2
929900
0
0
BURLINGTON STORES INC
COM
122017106
3318
19500
SH
DFND
19500
0
0
CAESARSTONE LTD
ORD SHS
M20598104
8091
538316
SH
DFND
538316
0
0
CAMTEK LTD
ORD
M20791105
3528
417459
SH
DFND
417459
0
0
CELGENE CORP
COM
151020104
23110
250000
SH
DFND
1,2
250000
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
191
87500
SH
DFND
1,2
87500
0
0
CHARTER COMMUNICATIONS INC N
CL A
16119P108
2371
6000
SH
DFND
6000
0
0
CUE BIOPHARMA INC
COM
22978P106
450
50000
SH
DFND
1,2
50000
0
0
DELEK US HLDGS INC NEW
COM
24665A103
338
8347
SH
DFND
8347
0
0
DICERNA PHARMACEUTICALS INC
COM
253031108
4956
314642
SH
DFND
1,2
314642
0
0
ERYTECH PHARMA
SPONSORED ADR
29604W108
853
119037
SH
DFND
1,2
119037
0
0
FISERV INC
COM
337738108
3680
40365
SH
DFND
40365
0
0
FIVERR INTL LTD
ORD SHS
M4R82T106
2079
70000
SH
DFND
70000
0
0
FORESCOUT TECHNOLOGIES INC
COM
34553D101
5853
172846
SH
DFND
172846
0
0
GLAXOSMITHKLINE PLC
SPONSORED ADR
37733W105
20010
500000
SH
DFND
1,2
500000
0
0
HARPOON THERAPEUTICS INC
COM
41358P106
4862
374031
SH
DFND
1,2
374031
0
0
HEALTH SCIENCES ACQUSTN CORP
UNIT 04/01/2024
42227C201
1055
100000
SH
DFND
1,2
100000
0
0
INTEC PHARMA LTD JERUSALEM
SHS
M53644106
2691
620000
SH
DFND
1,2
620000
0
0
INTERCEPT PHARMACEUTICALS IN
COM
45845P108
9230
116000
SH
DFND
1,2
116000
0
0
INTERNATIONAL FLAVORS&FRAGRA
COM
459506101
4353
30000
SH
DFND
30000
0
0
INTERNATIONAL FLAVORS&FRAGRA
CALL
459506101
9213
63500
SH
Call
DFND
0
0
0
INTRA CELLULAR THERAPIES INC
CALL
46116X101
3894
300000
SH
Call
DFND
1,2
0
0
0
ISHARES TR
20 YR TR BD ETF
464287432
5976
45000
SH
DFND
45000
0
0
ITURAN LOCATION AND CONTROL
SHS
M6158M104
3912
130000
SH
DFND
130000
0
0
JOHNSON & JOHNSON
COM
478160104
55712
400000
SH
DFND
1,2
400000
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
534
69200
SH
DFND
1,2
69200
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
5739
181274
SH
DFND
181274
0
0
KRYSTAL BIOTECH INC
COM
501147102
4737
117625
SH
DFND
1,2
117625
0
0
MAGIC SOFTWARE ENTERPRISES L
ORD
559166103
1662
185288
SH
DFND
185288
0
0
MARINUS PHARMACEUTICALS INC
COM
56854Q101
332
80000
SH
DFND
1,2
80000
0
0
MELLANOX TECHNOLOGIES LTD
SHS
M51363113
2569
23217
SH
DFND
23217
0
0
MERCK & CO INC
COM
58933Y105
37900
452000
SH
DFND
1,2
452000
0
0
MERSANA THERAPEUTICS INC
COM
59045L106
810
200000
SH
DFND
1,2
200000
0
0
MICROSOFT CORP
COM
594918104
7199
53741
SH
DFND
53741
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
4234
752018
SH
DFND
1,2
752018
0
0
MYLAN N V
SHS EURO
N59465109
7616
400000
SH
DFND
1,2
400000
0
0
MYOKARDIA INC
COM
62857M105
7020
140000
SH
DFND
1,2
140000
0
0
NEOS THERAPEUTICS INC
COM
64052L106
4788
3711454
SH
DFND
1,2
3711454
0
0
NICE LTD
SPONSORED ADR
653656108
243
1771
SH
DFND
1771
0
0
ORCHARD THERAPEUTICS PLC
ADS
68570P101
1503
107433
SH
DFND
1,2
107433
0
0
PALO ALTO NETWORKS INC
COM
697435105
5700
27976
SH
DFND
27976
0
0
PRECISION BIOSCIENCES INC
COM
74019P108
4439
335000
SH
DFND
1,2
335000
0
0
PREVAIL THERAPEUTICS INC
COM
74140Y101
1728
130930
SH
DFND
1,2
130930
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
4277
470000
SH
DFND
1,2
470000
0
0
RADWARE LTD
ORD
M81873107
2529
102277
SH
DFND
102277
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
10640
112769
SH
DFND
1,2
112769
0
0
REGENERON PHARMACEUTICALS
COM
75886F107
9390
30000
SH
DFND
1,2
30000
0
0
REGENXBIO INC
COM
75901B107
4909
95564
SH
DFND
1,2
95564
0
0
RETROPHIN INC
COM
761299106
10661
530678
SH
DFND
1,2
530678
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4650
310000
SH
DFND
1,2
310000
0
0
SANGAMO THERAPEUTICS INC
COM
800677106
3030
281291
SH
DFND
1,2
281291
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
6838
45000
SH
DFND
1,2
45000
0
0
SAREPTA THERAPEUTICS INC
CALL
803607100
18234
120000
SH
Call
DFND
1,2
0
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
10791
172762
SH
DFND
172762
0
0
SPDR SERIES TRUST
S&P HOMEBUILD
78464A888
6952
166796
SH
DFND
166796
0
0
STOKE THERAPEUTICS INC
COM
86150R107
9718
350944
SH
DFND
1,2
350944
0
0
SUTRO BIOPHARMA INC
COM
869367102
5074
445889
SH
DFND
1,2
445889
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
6830
740000
SH
DFND
1,2
740000
0
0
TEVA PHARMACEUTICAL INDS LTD
CALL
881624209
18921
2050000
SH
Call
DFND
0
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
497
53834
SH
DFND
53834
0
0
UNIQURE NV
SHS
N90064101
4701
60149
SH
DFND
1,2
60149
0
0
UNIQURE NV
CALL
N90064101
20710
265000
SH
Call
DFND
1,2
0
0
0
UROGEN PHARMA LTD
COM
M96088105
11083
308377
SH
DFND
1,2
308377
0
0
VERINT SYS INC
COM
92343X100
23263
432552
SH
DFND
432552
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
489
673628
SH
DFND
1,2
673628
0
0
WABTEC CORP
COM
929740108
2870
40000
SH
DFND
40000
0
0
WAVE LIFE SCIENCES LTD
SHS
Y95308105
8035
307967
SH
DFND
1,2
307967
0
0
WIX COM LTD
SHS
M98068105
2940
20690
SH
DFND
20690
0
0
X4 PHARMACEUTICALS INC
COM
98420X103
711
47391
SH
DFND
1,2
47391
0
0
Y MABS THERAPEUTICS INC
COM
984241109
4345
190000
SH
DFND
1,2
190000
0
0