0001178913-19-000472.txt : 20190214
0001178913-19-000472.hdr.sgml : 20190214
20190214064217
ACCESSION NUMBER: 0001178913-19-000472
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20181231
FILED AS OF DATE: 20190214
DATE AS OF CHANGE: 20190214
EFFECTIVENESS DATE: 20190214
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 19600578
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
12-31-2018
12-31-2018
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
02-11-2019
2
100
887207
true
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ABEONA THERAPEUTICS INC
COM
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270036
SH
DFND
1,2
270036
0
0
AC IMMUNE SA
SHS
H00263105
2935
310613
SH
DFND
1,2
310613
0
0
ADVERUM BIOTECHNOLOGIES INC
COM
00773U108
200
63355
SH
DFND
1,2
63355
0
0
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
4494
600000
SH
DFND
1,2
600000
0
0
AERPIO PHARMACEUTICALS INC
COM
00810B105
1924
1131819
SH
DFND
1,2
1131819
0
0
AGIOS PHARMACEUTICALS INC
COM
00847X104
3112
67500
SH
DFND
1,2
67500
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
10226
1232089
SH
DFND
1,2
1232089
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
16366
168100
SH
DFND
1,2
168100
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
1881
345199
SH
DFND
1,2
345199
0
0
ALLOGENE THERAPEUTICS INC
COM
019770106
3055
113437
SH
DFND
1,2
113437
0
0
ALLOT COMMUNICATIONS LTD
SHS
M0854Q105
13513
595764
SH
DFND
595764
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
23452
2447994
SH
DFND
1,2
2447994
0
0
APELLIS PHARMACEUTICALS INC
COM
03753U106
1543
117000
SH
DFND
1,2
117000
0
0
ARGENX SE
SPONSORED ADR
04016X101
8366
87081
SH
DFND
1,2
87081
0
0
ARQULE INC
COM
04269E107
5630
2032643
SH
DFND
1,2
2032643
0
0
ARRAY BIOPHARMA INC
COM
04269X105
1781
125000
SH
DFND
1,2
125000
0
0
ARVINAS INC
COM
04335A105
3483
271053
SH
DFND
1,2
271053
0
0
ARYA SCIENCES ACQUISITION CO
SHS CL A
G3165V109
2048
200000
SH
DFND
1,2
200000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
3651
58273
SH
DFND
1,2
58273
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
19560
515000
SH
DFND
1,2
515000
0
0
AUTOLUS THERAPEUTICS PLC
SPON ADS
05280R100
6666
202994
SH
DFND
1,2
202994
0
0
AXOVANT SCIENCES LTD
COM
G0750W104
8167
8200000
SH
DFND
1,2
8200000
0
0
BENITEC BIOPHARMA LTD
SPONS ADR NEW
082053307
180
120000
SH
DFND
1,2
120000
0
0
BIOHAVEN PHARMACTL HLDG CO L
COM
G11196105
4919
133015
SH
DFND
1,2
133015
0
0
BLUEBIRD BIO INC
COM
09609G100
13769
138796
SH
DFND
1,2
138796
0
0
BRISTOL MYERS SQUIBB CO
COM
110122108
32747
630000
SH
DFND
1,2
630000
0
0
CAESARSTONE LTD
ORD SHS
M20598104
23808
469160
SH
DFND
469160
0
0
CARA THERAPEUTICS INC
COM
140755109
3951
303930
SH
DFND
1,2
303930
0
0
CELGENE CORP
COM
151020104
29802
465000
SH
DFND
1,2
465000
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
136
87500
SH
DFND
1,2
87500
0
0
CELLECTIS S A
SPONSORED ADS
15117K103
7459
447970
SH
DFND
1,2
447970
0
0
CLEARSIDE BIOMEDICAL INC
COM
185063104
1268
1185124
SH
DFND
1,2
1185124
0
0
CONSTELLATION PHARMCETICLS I
COM
210373106
281
70162
SH
DFND
1,2
70162
0
0
CORVUS PHARMACEUTICALS INC
COM
221015100
1180
321430
SH
DFND
1,2
321430
0
0
CUE BIOPHARMA INC
COM
22978P106
235
50000
SH
DFND
1,2
50000
0
0
CYTOMX THERAPEUTICS INC
COM
23284F105
4125
273151
SH
DFND
1,2
273151
0
0
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
2415
115033
SH
DFND
1,2
115033
0
0
DOVA PHARMACEUTICALS INC
COM
25985T102
1402
185000
SH
DFND
1,2
185000
0
0
EPIZYME INC
COM
29428V104
4617
749502
SH
DFND
1,2
749502
0
0
ERYTECH PHARMA
SPONSORED ADR
29604W108
796
120000
SH
DFND
1,2
120000
0
0
EVOKE PHARMA INC
COM
30049G104
3499
1410946
SH
DFND
1,2
1410946
0
0
FORESCOUT TECHNOLOGIES INC
COM
34553D101
5746
59169
SH
DFND
59169
0
0
GILAT SATELLITE NETWORKS LTD
SHS NEW
M51474118
5705
166663
SH
DFND
166663
0
0
GILEAD SCIENCES INC
COM
375558103
21893
350000
SH
DFND
1,2
350000
0
0
GLAXOSMITHKLINE PLC
SPONSORED ADR
37733W105
11845
310000
SH
DFND
1,2
310000
0
0
GLOBAL BLOOD THERAPEUTICS IN
COM
37890U108
6034
147000
SH
DFND
1,2
147000
0
0
GLYCOMIMETICS INC
COM
38000Q102
2377
251013
SH
DFND
1,2
251013
0
0
GW PHARMACEUTICALS PLC
ADS
36197T103
7499
77000
SH
DFND
1,2
77000
0
0
HOMOLOGY MEDICINES INC
COM
438083107
3600
161000
SH
DFND
1,2
161000
0
0
IDERA PHARMACEUTICALS INC
COM PAR
45168K405
1234
445558
SH
DFND
1,2
445558
0
0
IMMUNOMEDICS INC
COM
452907108
10082
706539
SH
DFND
1,2
706539
0
0
ITURAN LOCATION AND CONTROL
SHS
M6158M104
14637
122177
SH
DFND
122177
0
0
KADMON HLDGS INC
COM
48283N106
3099
1490000
SH
DFND
1,2
1490000
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
472
20000
SH
DFND
1,2
20000
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
2122
30342
SH
DFND
30342
0
0
KRYSTAL BIOTECH INC
COM
501147102
3629
174625
SH
DFND
1,2
174625
0
0
LOGICBIO THERAPEUTICS INC
COM
54142F102
4343
417625
SH
DFND
1,2
417625
0
0
MEIRAGTX HOLDINGS PLC
COM
G59665102
686
71159
SH
DFND
1,2
71159
0
0
MELINTA THERAPEUTICS INC
COM
58549G100
1282
1616867
SH
DFND
1,2
1616867
0
0
MELLANOX TECHNOLOGIES LTD
SHS
M51363113
9787
28351
SH
DFND
28351
0
0
MERCK & CO INC
COM
58933Y105
36066
472000
SH
DFND
1,2
472000
0
0
MICROSOFT CORP
COM
594918104
17838
46998
SH
DFND
46998
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
5271
782018
SH
DFND
1,2
782018
0
0
MOHAWK INDS INC
COM
608190104
4659
10661
SH
DFND
10661
0
0
MOLECULAR TEMPLATES INC
COM
608550109
1616
400000
SH
DFND
1,2
400000
0
0
MYLAN N V
SHS EURO
N59465109
45956
1677241
SH
DFND
1,2
1677241
0
0
NEOS THERAPEUTICS INC
COM
64052L106
3633
2201697
SH
DFND
1,2
2201697
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
1286
250000
SH
DFND
250000
0
0
ORCHARD THERAPEUTICS PLC
ADS
68570P101
5820
370000
SH
DFND
1,2
370000
0
0
OSMOTICA PHARMACEUTICALS PLC
SHS
G6S41R101
7147
922200
SH
DFND
1,2
922200
0
0
PALO ALTO NETWORKS INC
COM
697435105
17514
24885
SH
DFND
24885
0
0
PIERIS PHARMACEUTICALS INC
COM
720795103
1862
700000
SH
DFND
1,2
700000
0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
2869
147000
SH
DFND
1,2
147000
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
5365
340000
SH
DFND
1,2
340000
0
0
PTC THERAPEUTICS INC
COM
69366J200
11858
345500
SH
DFND
1,2
345500
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
12413
221269
SH
DFND
1,2
221269
0
0
RETROPHIN INC
COM
761299106
7370
325678
SH
DFND
1,2
325678
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4298
290001
SH
DFND
1,2
290001
0
0
SAGE THERAPEUTICS INC
PUT
78667J108
2347
24500
SH
Put
DFND
1,2
24500
0
0
SAGE THERAPEUTICS INC
COM
78667J108
9914
103500
SH
DFND
1,2
103500
0
0
SANGAMO THERAPEUTICS INC
COM
800677106
3903
340000
SH
DFND
1,2
340000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
12716
116517
SH
DFND
1,2
116517
0
0
SAVARA INC
COM
805111101
833
110000
SH
DFND
1,2
110000
0
0
SCHOLAR ROCK HLDG CORP
COM
80706P103
4031
175511
SH
DFND
1,2
175511
0
0
SIERRA ONCOLOGY INC
COM
82640U107
341
258510
SH
DFND
1,2
258510
0
0
SPDR SERIES TRUST
PUT
78464A870
193725
2700000
SH
Put
DFND
1,2
2700000
0
0
SPDR SERIES TRUST
S&P BIOTECH
78464A870
3228
45000
SH
DFND
1,2
45000
0
0
SPRING BK PHARMACEUTICALS IN
COM
849431101
530
51015
SH
DFND
1,2
51015
0
0
STRONGBRIDGE BIOPHARMA PLC
SHS USD
G85347105
4174
931600
SH
DFND
1,2
931600
0
0
SUTRO BIOPHARMA INC
COM
869367102
3679
407889
SH
DFND
1,2
407889
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADR
881624209
10863
704500
SH
DFND
1,2
704500
0
0
TRANSLATE BIO INC
COM
89374L104
2321
309400
SH
DFND
1,2
309400
0
0
UNIQURE NV
SHS
N90064101
6711
232849
SH
DFND
1,2
232849
0
0
UROVANT SCIENCES LTD
SHS
G9381B108
1410
214030
SH
DFND
1,2
214030
0
0
VERINT SYS INC
COM
92343X100
23573
149100
SH
DFND
149100
0
0
VERRICA PHARMACEUTICALS INC
COM
92511W108
791
97000
SH
DFND
1,2
97000
0
0
VIKING THERAPEUTICS INC
COM
92686J106
5705
745727
SH
DFND
1,2
745727
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
2211
1473918
SH
DFND
1,2
1473918
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
2836
449484
SH
DFND
1,2
449484
0
0
ZAFGEN INC
COM
98885E103
1881
380000
SH
DFND
1,2
380000
0
0