0001178913-18-002945.txt : 20181114
0001178913-18-002945.hdr.sgml : 20181114
20181114123957
ACCESSION NUMBER: 0001178913-18-002945
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20180930
FILED AS OF DATE: 20181114
DATE AS OF CHANGE: 20181114
EFFECTIVENESS DATE: 20181114
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 181182046
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
09-30-2018
09-30-2018
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Ori Goldfarb
Chief Executive Officer
972-3-6845535
/s/ Ori Goldfarb
Tel Aviv
L3
11-13-2018
2
113
871050
true
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ABEONA THERAPEUTICS INC
COM
00289Y107
4313
336939
SH
DFND
1,2
336939
0
0
AC IMMUNE SA
SHS
H00263105
4029
503563
SH
DFND
1,2
503563
0
0
ADVANCE AUTO PARTS INC
COM
00751Y106
898
5336
SH
DFND
5336
0
0
ADVERUM BIOTECHNOLOGIES INC
COM
00773U108
454
75000
SH
DFND
1,2
75000
0
0
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
6250
653112
SH
DFND
1,2
653112
0
0
AERPIO PHARMACEUTICALS INC
COM
00810B105
3497
1131819
SH
DFND
1,2
1131819
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
15761
1142089
SH
DFND
1,2
1142089
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
19698
141700
SH
DFND
1,2
141700
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
3170
295199
SH
DFND
1,2
295199
0
0
ALLOT COMMUNICATIONS LTD
SHS
M0854Q105
2326
376451
SH
DFND
376451
0
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
3501
40000
SH
DFND
1,2
40000
0
0
ALPHABET INC
CAP STK CL A
02079K305
3946
3269
SH
DFND
3269
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
21617
1787994
SH
DFND
1,2
1787994
0
0
APELLIS PHARMACEUTICALS INC
COM
03753U106
3778
212470
SH
DFND
1,2
212470
0
0
AQUESTIVE THERAPEUTICS INC
COM
03843E104
1669
95300
SH
DFND
1,2
95300
0
0
ARBUTUS BIOPHARMA CORP
COM
03879J100
378
40000
SH
DFND
1,2
40000
0
0
ARGENX SE
SPONSORED ADR
04016X101
10343
136381
SH
DFND
1,2
136381
0
0
ARQULE INC
COM
04269E107
11350
2005243
SH
DFND
1,2
2005243
0
0
ARRAY BIOPHARMA INC
COM
04269X105
6004
395000
SH
DFND
1,2
395000
0
0
ARVINAS INC
COM
04335A105
4049
240000
SH
DFND
1,2
240000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
6567
92673
SH
DFND
1,2
92673
0
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
3730
100431
SH
DFND
1,2
100431
0
0
AUDENTES THERAPEUTICS INC
COM
05070R104
4751
120000
SH
DFND
1,2
120000
0
0
AUDIOCODES LTD
ORD
M15342104
596
59226
SH
DFND
59226
0
0
AUTOLUS THERAPEUTICS PLC
SPON ADS
05280R100
8935
296251
SH
DFND
1,2
296251
0
0
BENITEC BIOPHARMA LTD
SPONS ADR NEW
082053307
294
120000
SH
DFND
1,2
120000
0
0
BIOHAVEN PHARMACTL HLDG CO L
COM
G11196105
5840
155515
SH
DFND
1,2
155515
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
8533
88000
SH
DFND
1,2
88000
0
0
BLUEBIRD BIO INC
COM
09609G100
11446
78396
SH
DFND
1,2
78396
0
0
BRISTOL MYERS SQUIBB CO
COM
110122108
33523
540000
SH
DFND
1,2
540000
0
0
CAESARSTONE LTD
ORD SHS
M20598104
10412
561311
SH
DFND
561311
0
0
CARA THERAPEUTICS INC
COM
140755109
6130
255930
SH
DFND
1,2
255930
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
263
87500
SH
DFND
1,2
87500
0
0
CELLECTIS S A
SPONSORED ADS
15117K103
12642
447970
SH
DFND
1,2
447970
0
0
CHARTER COMMUNICATIONS INC N
CL A
16119P108
462
1419
SH
DFND
1419
0
0
CISCO SYS INC
COM
17275R102
4865
100000
SH
DFND
100000
0
0
CISION LTD
SHS
G1992S109
252
15000
SH
DFND
15000
0
0
CLEARSIDE BIOMEDICAL INC
COM
185063104
7101
1154690
SH
DFND
1,2
1154690
0
0
COMCAST CORP NEW
CL A
20030N101
212
5993
SH
DFND
5993
0
0
CORVUS PHARMACEUTICALS INC
COM
221015100
2758
321430
SH
DFND
1,2
321430
0
0
CUE BIOPHARMA INC
COM
22978P106
181
20000
SH
DFND
1,2
20000
0
0
CYTOMX THERAPEUTICS INC
COM
23284F105
4313
233151
SH
DFND
1,2
233151
0
0
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
4260
110033
SH
DFND
1,2
110033
0
0
DOVA PHARMACEUTICALS INC
COM
25985T102
2516
120000
SH
DFND
1,2
120000
0
0
EIDOS THERAPEUTICS INC
COM
28249H104
315
31522
SH
DFND
1,2
31522
0
0
EPIZYME INC
COM
29428V104
4235
399502
SH
DFND
1,2
399502
0
0
ERYTECH PHARMA
SPONSORED ADR
29604W108
1046
120000
SH
DFND
1,2
120000
0
0
EVOKE PHARMA INC
COM
30049G104
4205
1410946
SH
DFND
1,2
1410946
0
0
FLEX LTD
ORD
Y2573F102
2093
159549
SH
DFND
159549
0
0
FORESCOUT TECHNOLOGIES INC
COM
34553D101
4700
124463
SH
DFND
124463
0
0
GILAT SATELLITE NETWORKS LTD
SHS NEW
M51474118
1398
163367
SH
DFND
163367
0
0
GILEAD SCIENCES INC
COM
375558103
32428
420000
SH
DFND
1,2
420000
0
0
GLAXOSMITHKLINE PLC
SPONSORED ADR
37733W105
34747
865000
SH
DFND
1,2
865000
0
0
GLYCOMIMETICS INC
COM
38000Q102
3615
251013
SH
DFND
1,2
251013
0
0
HOMOLOGY MEDICINES INC
COM
438083107
5603
245104
SH
DFND
1,2
245104
0
0
IDERA PHARMACEUTICALS INC
COM NEW
45168K306
3970
445558
SH
DFND
1,2
445558
0
0
IMMUNOMEDICS INC
COM
452907108
14561
699039
SH
DFND
1,2
699039
0
0
INTERNATIONAL FLAVORS&FRAGRA
COM
459506101
5071
36450
SH
DFND
36450
0
0
JOHNSON & JOHNSON
COM
478160104
44905
325000
SH
DFND
1,2
325000
0
0
KADMON HLDGS INC
COM
48283N106
4977
1490000
SH
DFND
1,2
1490000
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
4539
212000
SH
DFND
1,2
212000
0
0
LEAP THERAPEUTICS INC
COM
52187K101
2590
332525
SH
DFND
1,2
332525
0
0
LOWES COS INC
COM
548661107
287
2500
SH
DFND
2500
0
0
MASTERCARD INCORPORATED
CL A
57636Q104
5067
22760
SH
DFND
22760
0
0
MELINTA THERAPEUTICS INC
COM
58549G100
6387
1616867
SH
DFND
1,2
1616867
0
0
MELLANOX TECHNOLOGIES LTD
SHS
M51363113
3679
50093
SH
DFND
50093
0
0
MERCK & CO INC
COM
58933Y105
55333
780000
SH
DFND
1,2
780000
0
0
MICROSOFT CORP
COM
594918104
7967
69656
SH
DFND
69656
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
10572
842391
SH
DFND
1,2
842391
0
0
MIRATI THERAPEUTICS INC
COM
60468T105
5318
112908
SH
DFND
1,2
112908
0
0
MOLECULAR TEMPLATES INC
COM
608550109
2156
400000
SH
DFND
1,2
400000
0
0
MYLAN N V
SHS EURO
N59465109
48495
1325000
SH
DFND
1,2
1325000
0
0
NEOS THERAPEUTICS INC
COM
64052L106
4034
831697
SH
DFND
1,2
831697
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
359
250000
SH
DFND
250000
0
0
O REILLY AUTOMOTIVE INC NEW
COM
67103H107
3766
10844
SH
DFND
10844
0
0
OBSEVA SA
COM
H5861P103
4393
243669
SH
DFND
1,2
243669
0
0
PIERIS PHARMACEUTICALS INC
COM
720795103
5066
904686
SH
DFND
1,2
904686
0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
3915
147000
SH
DFND
1,2
147000
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
7716
398749
SH
DFND
1,2
398749
0
0
PTC THERAPEUTICS INC
COM
69366J200
9870
210000
SH
DFND
1,2
210000
0
0
RADWARE LTD
ORD
M81873107
464
17527
SH
DFND
17527
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
7581
92719
SH
DFND
1,2
92719
0
0
RETROPHIN INC
COM
761299106
9357
325678
SH
DFND
1,2
325678
0
0
SAGE THERAPEUTICS INC
COM
78667J108
8475
60000
SH
DFND
1,2
60000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
12293
76116
SH
DFND
1,2
76116
0
0
SAVARA INC
COM
805111101
2339
209596
SH
DFND
1,2
209596
0
0
SCHOLAR ROCK HLDG CORP
COM
80706P103
7644
296856
SH
DFND
1,2
296856
0
0
SERVICEMASTER GLOBAL HLDGS I
COM
81761R109
395
9500
SH
DFND
9500
0
0
SESEN BIO INC
COM
817763105
1355
630000
SH
DFND
1,2
630000
0
0
SIERRA ONCOLOGY INC
COM
82640U107
1739
1022759
SH
DFND
1,2
1022759
0
0
SITEONE LANDSCAPE SUPPLY INC
COM
82982L103
226
3000
SH
DFND
3000
0
0
SNAP ON INC
COM
833034101
3978
21666
SH
DFND
21666
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
5678
150817
SH
DFND
150817
0
0
SPDR SERIES TRUST
PUT
78464A870
105457
1100000
SH
Put
DFND
1,2
1100000
0
0
STRONGBRIDGE BIOPHARMA PLC
SHS USD
G85347105
5718
1179010
SH
DFND
1,2
1179010
0
0
SUTRO BIOPHARMA INC
COM
869367102
4125
275000
SH
DFND
1,2
275000
0
0
TEVA PHARMACEUTICAL FIN LLC
DBCV 0.250% 2/0
88163VAE9
862
2135
SH
DFND
2135
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADR
881624209
4308
200000
SH
DFND
1,2
200000
0
0
TRANSLATE BIO INC
COM
89374L104
2766
276639
SH
DFND
1,2
276639
0
0
ULTIMATE SOFTWARE GROUP INC
COM
90385D107
258
800
SH
DFND
800
0
0
UNIQURE NV
SHS
N90064101
6472
177849
SH
DFND
1,2
177849
0
0
UNITEDHEALTH GROUP INC
COM
91324P102
532
2000
SH
DFND
2000
0
0
UROVANT SCIENCES LTD
SHS
G9381B108
1968
164030
SH
DFND
1,2
164030
0
0
VERINT SYS INC
COM
92343X100
7521
150126
SH
DFND
150126
0
0
VERRICA PHARMACEUTICALS INC
COM
92511W108
1901
117000
SH
DFND
1,2
117000
0
0
VIKING THERAPEUTICS INC
CALL
92686J106
416
23900
SH
Call
DFND
1,2
0
0
0
VIKING THERAPEUTICS INC
COM
92686J106
14976
859727
SH
DFND
1,2
859727
0
0
VISA INC
COM CL A
92826C839
6064
40401
SH
DFND
40401
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
2427
1673918
SH
DFND
1,2
1673918
0
0
WABTEC CORP
COM
929740108
5571
53114
SH
DFND
53114
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
5009
379484
SH
DFND
1,2
379484
0
0
ZAFGEN INC
COM
98885E103
5027
430000
SH
DFND
1,2
430000
0
0
ZYMEWORKS INC
COM
98985W102
1159
73800
SH
DFND
1,2
73800
0
0