0001178913-18-001571.txt : 20180510
0001178913-18-001571.hdr.sgml : 20180510
20180510084429
ACCESSION NUMBER: 0001178913-18-001571
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20180331
FILED AS OF DATE: 20180510
DATE AS OF CHANGE: 20180510
EFFECTIVENESS DATE: 20180510
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 18820677
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
03-31-2018
03-31-2018
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845520
/s/ Israel Mor
Tel Aviv
L3
05-10-2018
2
108
658645
true
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ABEONA THERAPEUTICS INC
COM
00289Y107
4233
295000
SH
DFND
1,2
295000
0
0
ADAMAS PHARMACEUTICALS INC
COM
00548A106
8018
335500
SH
DFND
1,2
335500
0
0
ADVANCE AUTO PARTS INC
COM
00751Y106
633
5336
SH
DFND
5336
0
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
7568
1009131
SH
DFND
1,2
1009131
0
0
ALEXION PHARMACEUTICALS INC
COM
015351109
9140
82000
SH
DFND
1,2
82000
0
0
ALLENA PHARMACEUTICALS INC
COM
018119107
4520
410199
SH
DFND
1,2
410199
0
0
ALLERGAN PLC
SHS
G0177J108
10097
60000
SH
DFND
1,2
60000
0
0
ALPHABET INC
CAP STK CL A
02079K305
4970
4792
SH
DFND
4792
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
27759
1845704
SH
DFND
1,2
1845704
0
0
AQUINOX PHARMACEUTICALS INC
COM
03842B101
1064
75535
SH
DFND
1,2
75535
0
0
ARQULE INC
COM
04269E107
5075
1762000
SH
DFND
1,2
1762000
0
0
ARQULE INC
COM
04269E107
1446
502136
SH
DFND
1,2
502136
0
0
ARRAY BIOPHARMA INC
COM
04269X105
6610
405000
SH
DFND
1,2
405000
0
0
ARSANIS INC
COM
042873109
2632
114972
SH
DFND
1,2
114972
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
6244
95474
SH
DFND
1,2
95474
0
0
ATHERSYS INC
COM
04744L106
1
773
SH
DFND
1,2
773
0
0
AUDENTES THERAPEUTICS INC
COM
05070R104
2855
95000
SH
DFND
1,2
95000
0
0
BIOGEN INC
COM
09062X103
17798
65000
SH
DFND
1,2
65000
0
0
BIOHAVEN PHARMACTL HLDG CO L
COM
G11196105
3377
131100
SH
DFND
1,2
131100
0
0
CAESARSTONE LTD
ORD SHS
M20598104
240
12195
SH
DFND
12195
0
0
CELGENE CORP
COM
151020104
28458
319000
SH
DFND
1,2
319000
0
0
CELLECTIS S A
SPONSORED ADS
15117K103
10693
339367
SH
DFND
1,2
339367
0
0
CHARTER COMMUNICATIONS INC N
CL A
16119P108
1036
3329
SH
DFND
3329
0
0
CLEARSIDE BIOMEDICAL INC
COM
185063104
11052
1030000
SH
DFND
1,2
1030000
0
0
CLEMENTIA PHARMACEUTICALS IN
COM
185575107
3030
200000
SH
DFND
1,2
200000
0
0
CLOVIS ONCOLOGY INC
COM
189464100
8870
168000
SH
DFND
1,2
168000
0
0
COHERUS BIOSCIENCES INC
COM
19249H103
2984
270000
SH
DFND
1,2
270000
0
0
COMCAST CORP NEW
CL A
20030N101
342
10000
SH
DFND
10000
0
0
CORVUS PHARMACEUTICALS INC
COM
221015100
3706
321430
SH
DFND
1,2
321430
0
0
CTI BIOPHARMA CORP
COM NEW
12648L601
3251
833633
SH
DFND
1,2
833633
0
0
CYTOMX THERAPEUTICS INC
COM
23284F105
5121
180000
SH
DFND
1,2
180000
0
0
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
819
40846
SH
DFND
1,2
40846
0
0
DELEK US HLDGS INC NEW
COM
24665A103
4977
122284
SH
DFND
122284
0
0
DENTSPLY SIRONA INC
COM
24906P109
126
2500
SH
DFND
2500
0
0
EIGER BIOPHARMACEUTICALS INC
COM
28249U105
4679
475000
SH
DFND
1,2
475000
0
0
ENDO INTL PLC
SHS
G30401106
3267
550000
SH
DFND
1,2
550000
0
0
ERYTECH PHARMA
SPONSORED ADR
29604W108
2520
120000
SH
DFND
1,2
120000
0
0
EVOKE PHARMA INC
COM
30049G104
819
393852
SH
DFND
1,2
393852
0
0
EXPEDIA GROUP INC
COM NEW
30212P303
2087
18900
SH
DFND
18900
0
0
FACEBOOK INC
CL A
30303M102
974
6097
SH
DFND
6097
0
0
FIBROGEN INC
COM
31572Q808
1838
39779
SH
DFND
1,2
39779
0
0
FLEX LTD
ORD
Y2573F102
5027
307839
SH
DFND
307839
0
0
GCI LIBERTY INC
COM CLASS A
36164V305
159
3000
SH
DFND
3000
0
0
GEMPHIRE THERAPEUTICS INC
COM
36870A108
3132
481046
SH
DFND
1,2
481046
0
0
GILAT SATELLITE NETWORKS LTD
SHS NEW
M51474118
985
111646
SH
DFND
111646
0
0
GLAXOSMITHKLINE PLC
SPONSORED ADR
37733W105
19535
500000
SH
DFND
1,2
500000
0
0
GLYCOMIMETICS INC
COM
38000Q102
2435
150000
SH
DFND
1,2
150000
0
0
HOMOLOGY MEDICINES INC
COM
438083107
2487
133000
SH
DFND
1,2
133000
0
0
IMMUNOMEDICS INC
COM
452907108
7013
480000
SH
DFND
1,2
480000
0
0
INNOVATE BIOPHARMACEUTICLS I
COM PAR
45782F105
12256
980502
SH
DFND
1,2
980502
0
0
INTELLIA THERAPEUTICS INC
COM
45826J105
3374
160000
SH
DFND
1,2
160000
0
0
KADMON HLDGS INC
COM
48283N106
6333
1490000
SH
DFND
1,2
1490000
0
0
KURA ONCOLOGY INC
COM
50127T109
6188
330000
SH
DFND
1,2
330000
0
0
LA JOLLA PHARMACEUTICAL CO
COM PAR $.0001 2
503459604
7743
260000
SH
DFND
1,2
260000
0
0
LAM RESEARCH CORP
COM
512807108
2713
13356
SH
DFND
13356
0
0
LEAP THERAPEUTICS INC
COM
52187K101
3545
427086
SH
DFND
1,2
427086
0
0
LIVEPERSON INC
COM
538146101
2
136
SH
DFND
136
0
0
MACROGENICS INC
COM
556099109
3397
135000
SH
DFND
1,2
135000
0
0
MASTERCARD INCORPORATED
CL A
57636Q104
2895
16525
SH
DFND
16525
0
0
MEDICINOVA INC
COM NEW
58468P206
6447
630838
SH
DFND
1,2
630838
0
0
MELINTA THERAPEUTICS INC
COM
58549G100
1805
243896
SH
DFND
1,2
243896
0
0
MELLANOX TECHNOLOGIES LTD
SHS
M51363113
7305
100279
SH
DFND
100279
0
0
MERCK & CO INC
COM
58933Y105
31593
580000
SH
DFND
1,2
580000
0
0
MICROSOFT CORP
COM
594918104
6101
66850
SH
DFND
66850
0
0
MINERVA NEUROSCIENCES INC
COM
603380106
4844
775000
SH
DFND
1,2
775000
0
0
MOHAWK INDS INC
COM
608190104
255
1100
SH
DFND
1100
0
0
MYLAN N V
SHS EURO
N59465109
23632
574000
SH
DFND
1,2
574000
0
0
NEOS THERAPEUTICS INC
COM
64052L106
2662
320692
SH
DFND
1,2
320692
0
0
NICE LTD
SPONSORED ADR
653656108
6365
67758
SH
DFND
67758
0
0
O REILLY AUTOMOTIVE INC NEW
COM
67103H107
2683
10844
SH
DFND
10844
0
0
OBSEVA SA
COM
H5861P103
10053
745197
SH
DFND
1,2
745197
0
0
PERRIGO CO PLC
SHS
G97822103
1600
19221
SH
DFND
19221
0
0
PFIZER INC
COM
717081103
20939
590000
SH
DFND
1,2
590000
0
0
PIERIS PHARMACEUTICALS INC
COM
720795103
5456
800000
SH
DFND
1,2
800000
0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
6532
200000
SH
Call
DFND
1,2
0
0
0
POWERSHARES QQQ TRUST
UNIT SER 1
73935A104
12810
80000
SH
Put
DFND
80000
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
2025
658500
SH
DFND
1,2
658500
0
0
PUMA BIOTECHNOLOGY INC
COM
74587V107
4083
60000
SH
DFND
1,2
60000
0
0
RADCOM LTD
SHS NEW
M81865111
1207
65760
SH
DFND
65760
0
0
RADWARE LTD
ORD
M81873107
389
18230
SH
DFND
18230
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
4615
225000
SH
DFND
1,2
225000
0
0
RECRO PHARMA INC
COM
75629F109
4010
364197
SH
DFND
1,2
364197
0
0
REGENERON PHARMACEUTICALS
COM
75886F107
14291
41500
SH
DFND
1,2
41500
0
0
REGENXBIO INC
COM
75901B107
2985
100000
SH
DFND
1,2
100000
0
0
RETROPHIN INC
COM
761299106
4919
220000
SH
DFND
1,2
220000
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
5668
302275
SH
DFND
1,2
302275
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
18448
248997
SH
DFND
1,2
248997
0
0
SEALED AIR CORP NEW
COM
81211K100
193
4500
SH
DFND
4500
0
0
SERVICEMASTER GLOBAL HLDGS I
COM
81761R109
483
9500
SH
DFND
9500
0
0
SHIRE PLC
SPONSORED ADR
82481R106
29355
196500
SH
DFND
1,2
196500
0
0
SIERRA ONCOLOGY INC
COM
82640U107
2070
1000000
SH
DFND
1,2
1000000
0
0
SITEONE LANDSCAPE SUPPLY INC
COM
82982L103
231
3000
SH
DFND
3000
0
0
SNAP ON INC
COM
833034101
202
1366
SH
DFND
1366
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
904
17190
SH
DFND
17190
0
0
SPDR SERIES TRUST
S&P BIOTECH
78464A870
65798
750000
SH
Put
DFND
1,2
750000
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
4247
298472
SH
DFND
1,2
298472
0
0
TESARO INC
COM
881569107
6067
106175
SH
DFND
1,2
106175
0
0
TEVA PHARMACEUTICAL FIN LLC
DBCV 0.250% 2/0
88163VAE9
703
2135
SH
DFND
2135
0
0
ULTIMATE SOFTWARE GROUP INC
COM
90385D107
195
800
SH
DFND
800
0
0
UNIQURE NV
SHS
N90064101
2999
127600
SH
DFND
1,2
127600
0
0
UNITEDHEALTH GROUP INC
COM
91324P102
428
2000
SH
DFND
2000
0
0
VBI VACCINES INC
COM NEW
91822J103
2332
666284
SH
DFND
1,2
666284
0
0
VIKING THERAPEUTICS INC
COM
92686J106
6959
1592416
SH
DFND
1,2
1592416
0
0
VISA INC
COM CL A
92826C839
4833
40401
SH
DFND
40401
0
0
VISTA OUTDOOR INC
COM
928377100
98
6000
SH
DFND
6000
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
1157
1247251
SH
DFND
1,2
1247251
0
0
VTV THERAPEUTICS INC
CL A
918385105
1146
281679
SH
DFND
1,2
281679
0
0
WATSCO INC
COM
942622200
380
2100
SH
DFND
2100
0
0