0001178913-18-000471.txt : 20180212 0001178913-18-000471.hdr.sgml : 20180212 20180212144454 ACCESSION NUMBER: 0001178913-18-000471 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20171231 FILED AS OF DATE: 20180212 DATE AS OF CHANGE: 20180212 EFFECTIVENESS DATE: 20180212 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 18595832 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 12-31-2017 12-31-2017 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor 972-3-6845520 /s/ Israel Mor Tel Aviv L3 02-12-2018 2 137 852232 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABEONA THERAPEUTICS INC COM 00289Y107 3329 210000 SH DFND 1,2 210000 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 5119 170000 SH DFND 1,2 170000 0 0 ACORDA THERAPEUTICS INC COM 00484M106 1073 50000 SH DFND 1,2 50000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 4762 140500 SH DFND 1,2 140500 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 2093 21000 SH Call DFND 0 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 831 8336 SH DFND 8336 0 0 AILERON THERAPEUTICS INC COM 00887A105 1318 125000 SH DFND 1,2 125000 0 0 ALBIREO PHARMA INC COM 01345P106 907 35431 SH DFND 1,2 35431 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 7100 1044131 SH DFND 1,2 1044131 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 14351 120000 SH DFND 1,2 120000 0 0 ALLENA PHARMACEUTICALS INC COM 018119107 3270 325000 SH DFND 1,2 325000 0 0 ALLERGAN PLC SHS G0177J108 9815 60000 SH DFND 1,2 60000 0 0 ALPHABET INC CAP STK CL A 02079K305 6075 5767 SH DFND 5767 0 0 AMICUS THERAPEUTICS INC COM 03152W109 15829 1100000 SH DFND 1,2 1100000 0 0 ANAPTYSBIO INC COM 032724106 3525 35000 SH DFND 1,2 35000 0 0 AQUINOX PHARMACEUTICALS INC COM 03842B101 888 75535 SH DFND 1,2 75535 0 0 ARDELYX INC COM 039697107 2277 345000 SH DFND 1,2 345000 0 0 ARRAY BIOPHARMA INC COM 04269X105 5184 405000 SH DFND 1,2 405000 0 0 ARSANIS INC COM 042873109 3436 269268 SH DFND 1,2 269268 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5187 129474 SH DFND 1,2 129474 0 0 ATHERSYS INC COM 04744L106 1 773 SH DFND 1,2 773 0 0 AUDENTES THERAPEUTICS INC COM 05070R104 2969 95000 SH DFND 1,2 95000 0 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390000 SH DFND 1,2 390000 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 6040 800000 SH DFND 1,2 800000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 10223 210000 SH DFND 1,2 210000 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 1709 530000 SH DFND 1,2 530000 0 0 PROTHENA CORP PLC SHS G72800108 7685 205000 SH DFND 1,2 205000 0 0 PUMA BIOTECHNOLOGY INC COM 74587V107 3460 35000 SH DFND 1,2 35000 0 0 RADCOM LTD SHS NEW M81865111 1305 65760 SH DFND 65760 0 0 REATA PHARMACEUTICALS INC CL A 75615P103 6372 225000 SH DFND 1,2 225000 0 0 REGENXBIO INC COM 75901B107 735 22107 SH DFND 1,2 22107 0 0 SAGE THERAPEUTICS INC COM 78667J108 395 2400 SH Put DFND 1,2 2400 0 0 SAGE THERAPEUTICS INC COM 78667J108 4941 30000 SH DFND 1,2 30000 0 0 SAREPTA THERAPEUTICS INC COM 803607100 21421 384997 SH DFND 1,2 384997 0 0 SAVARA INC COM 805111101 2968 200000 SH DFND 1,2 200000 0 0 SEALED AIR CORP NEW COM 81211K100 222 4500 SH DFND 4500 0 0 SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 4326 155000 SH DFND 155000 0 0 SELECTA BIOSCIENCES INC COM 816212104 2242 228534 SH DFND 1,2 228534 0 0 SERVICEMASTER GLOBAL HLDGS I COM 81761R109 410 8000 SH DFND 8000 0 0 SHIRE PLC SPONSORED ADR 82481R106 13418 86500 SH DFND 1,2 86500 0 0 SIERRA ONCOLOGY INC COM 82640U107 2052 550000 SH DFND 1,2 550000 0 0 SNAP ON INC COM 833034101 1271 7292 SH DFND 7292 0 0 SPARK THERAPEUTICS INC COM 84652J103 5142 100000 SH DFND 1,2 100000 0 0 SPDR SERIES TRUST S&P BIOTECH 78464A870 165497 1950000 SH Put DFND 1,2 1950000 0 0 SPRING BK PHARMACEUTICALS IN COM 849431101 999 74309 SH DFND 1,2 74309 0 0 STEMLINE THERAPEUTICS INC COM 85858C107 4680 300000 SH DFND 1,2 300000 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 2349 212018 SH DFND 1,2 212018 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 2177 248472 SH DFND 1,2 248472 0 0 TESARO INC COM 881569107 7873 95000 SH DFND 1,2 95000 0 0 TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 758 2135 SH DFND 2135 0 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 2250 118750 SH 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