Partner

0001178913-17-003094.txt : 20171109 0001178913-17-003094.hdr.sgml : 20171109 20171109113836 ACCESSION NUMBER: 0001178913-17-003094 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20170930 FILED AS OF DATE: 20171109 DATE AS OF CHANGE: 20171109 EFFECTIVENESS DATE: 20171109 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 171189563 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 09-30-2017 09-30-2017 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 11-09-2017 2 131 700903 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ACHILLION PHARMACEUTICALS IN COM 00448Q201 1347 300000 SH DFND 1,2 300000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 2445 115500 SH DFND 1,2 115500 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 2083 21000 SH Call DFND 0 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 266 2686 SH DFND 2686 0 0 AILERON THERAPEUTICS INC COM 00887A105 1673 125000 SH DFND 1,2 125000 0 0 ALBIREO PHARMA INC COM 01345P106 2274 108526 SH DFND 1,2 108526 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 7518 1044131 SH DFND 1,2 1044131 0 0 ALLERGAN PLC SHS G0177J108 12297 60000 SH DFND 1,2 60000 0 0 ALPHABET INC CAP STK CL A 02079K305 5615 5767 SH DFND 5767 0 0 AMICUS THERAPEUTICS INC COM 03152W109 6334 420000 SH DFND 1,2 420000 0 0 ANAPTYSBIO INC COM 032724106 2796 80000 SH DFND 1,2 80000 0 0 AQUINOX PHARMACEUTICALS INC COM 03842B101 1072 75535 SH DFND 1,2 75535 0 0 ARDELYX INC COM 039697107 1932 345000 SH DFND 1,2 345000 0 0 ARRAY BIOPHARMA INC COM 04269X105 4982 405000 SH DFND 1,2 405000 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 4693 129474 SH DFND 1,2 129474 0 0 ATHERSYS INC COM 04744L106 2 773 SH DFND 1,2 773 0 0 AUDENTES THERAPEUTICS INC COM 05070R104 2661 95000 SH DFND 1,2 95000 0 0 AVEO PHARMACEUTICALS INC COM 053588109 5110 1400000 SH DFND 1,2 1400000 0 0 AXOVANT SCIENCES LTD COM G0750W104 2064 300000 SH Put DFND 1,2 300000 0 0 AXOVANT SCIENCES LTD COM G0750W104 1238 180000 SH Call DFND 1,2 0 0 0 AXSOME THERAPEUTICS INC COM 05464T104 2781 501000 SH DFND 1,2 501000 0 0 BIOGEN INC COM 09062X103 32878 105000 SH DFND 1,2 105000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 7911 85000 SH DFND 1,2 85000 0 0 BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 2659 833633 SH DFND 1,2 833633 0 0 CAESARSTONE LTD ORD SHS M20598104 531 17833 SH DFND 17833 0 0 CASCADIAN THERAPEUTICS INC COM NEW 14740B606 2786 681210 SH DFND 1,2 681210 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 611 288030 SH DFND 1,2 288030 0 0 CELGENE CORP COM 151020104 40101 275000 SH DFND 1,2 275000 0 0 CELLCOM ISRAEL LTD SHS M2196U109 14301 1535988 SH DFND 1535988 0 0 CELLECTIS S A SPONSORED ADS 15117K103 9922 348736 SH DFND 1,2 348736 0 0 CHARTER COMMUNICATIONS INC N CL A 16119P108 4856 13362 SH DFND 13362 0 0 CHIPOTLE MEXICAN GRILL INC COM 169656105 123 400 SH DFND 400 0 0 CLEARSIDE BIOMEDICAL INC COM 185063104 2622 300000 SH DFND 1,2 300000 0 0 CLEMENTIA PHARMACEUTICALS IN COM 185575107 2753 163000 SH DFND 1,2 163000 0 0 CLOVIS ONCOLOGY INC COM 189464100 13019 158000 SH DFND 1,2 158000 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2239 30866 SH DFND 30866 0 0 COMCAST CORP NEW CL A 20030N101 2554 66360 SH DFND 66360 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 3530 221430 SH DFND 1,2 221430 0 0 CYTOKINETICS INC COM NEW 23282W605 1450 100000 SH Call DFND 1,2 0 0 0 CYTOKINETICS INC COM NEW 23282W605 3306 227990 SH DFND 1,2 227990 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 3816 210000 SH DFND 1,2 210000 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 1424 75000 SH DFND 1,2 75000 0 0 DENTSPLY SIRONA INC COM 24906P109 150 2500 SH DFND 2500 0 0 DOVA PHARMACEUTICALS INC COM 25985T102 1901 78284 SH DFND 1,2 78284 0 0 ECOLAB INC COM 278865100 257 2000 SH DFND 2000 0 0 EDGE THERAPEUTICS INC COM 279870109 3581 333737 SH DFND 1,2 333737 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 5723 520269 SH DFND 1,2 520269 0 0 EVOKE PHARMA INC COM 30049G104 1907 571022 SH DFND 1,2 571022 0 0 FACEBOOK INC CL A 30303M102 5496 32167 SH DFND 32167 0 0 FIBROGEN INC COM 31572Q808 6982 129779 SH DFND 1,2 129779 0 0 FIVE PRIME THERAPEUTICS INC COM 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