Partner

0001178913-17-001405.txt : 20170511 0001178913-17-001405.hdr.sgml : 20170511 20170511060853 ACCESSION NUMBER: 0001178913-17-001405 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20170331 FILED AS OF DATE: 20170511 DATE AS OF CHANGE: 20170511 EFFECTIVENESS DATE: 20170511 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 17832427 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 03-31-2017 03-31-2017 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 05-10-2017 2 112 511525 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ACCELERON PHARMA INC COM 00434H108 2647 100000 SH DFND 1,2 100000 0 0 ACHAOGEN INC COM 004449104 5046 200000 SH DFND 1,2 200000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 3421 195500 SH DFND 1,2 195500 0 0 ADVANCE AUTO PARTS INC CALL 00751Y906 2843 200 SH Call DFND 0 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 1666 11237 SH DFND 11237 0 0 AEVI GENOMIC MEDICINE INC COM 00835P105 753 405000 SH DFND 1,2 405000 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 3343 668500 SH DFND 1,2 668500 0 0 ALPHABET INC CAP STK CL A 02079K305 3685 4346 SH DFND 4346 0 0 AMICUS THERAPEUTICS INC COM 03152W109 3565 500000 SH DFND 1,2 500000 0 0 ANAPTYSBIO INC COM 032724106 708 25500 SH DFND 1,2 25500 0 0 ARDELYX INC COM 039697107 4364 345000 SH DFND 1,2 345000 0 0 ARRAY BIOPHARMA INC COM 04269X105 6258 700000 SH DFND 1,2 700000 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 7153 255455 SH DFND 1,2 255455 0 0 ATHERSYS INC COM 04744L106 1 773 SH DFND 1,2 773 0 0 AVEO PHARMACEUTICALS INC COM 053588109 1711 2900000 SH DFND 1,2 2900000 0 0 AVEXIS INC COM 05366U100 3421 45000 SH DFND 1,2 45000 0 0 AXSOME THERAPEUTICS INC COM 05464T104 1564 401000 SH DFND 1,2 401000 0 0 BELLICUM PHARMACEUTICALS INC COM 079481107 2468 200000 SH DFND 1,2 200000 0 0 BIOGEN INC COM 09062X103 20507 75000 SH DFND 1,2 75000 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 8157 150000 SH DFND 1,2 150000 0 0 CAESARSTONE LTD ORD SHS M20598104 3262 89974 SH DFND 89974 0 0 CASCADIAN THERAPEUTICS INC COM NEW 14740B606 2406 581210 SH DFND 1,2 581210 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 621 388030 SH DFND 1,2 388030 0 0 CELGENE CORP CALL 151020904 14886 1200 SH Call DFND 1,2 0 0 0 CELGENE CORP COM 151020104 31108 250000 SH DFND 1,2 250000 0 0 CELLECTIS S A SPONSORED ADS 15117K103 3832 159664 SH DFND 1,2 159664 0 0 CHARTER COMMUNICATIONS INC N CL A 16119P108 3915 11960 SH DFND 11960 0 0 CHIPOTLE MEXICAN GRILL INC COM 169656105 178 400 SH DFND 400 0 0 CLEARSIDE BIOMEDICAL INC COM 185063104 2382 300000 SH DFND 1,2 300000 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 5798 279166 SH DFND 1,2 279166 0 0 CYTOKINETICS INC COM NEW 23282W605 1956 152200 SH DFND 1,2 152200 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 2591 150000 SH DFND 1,2 150000 0 0 DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 3176 90167 SH DFND 1,2 90167 0 0 EDGE THERAPEUTICS INC COM 279870109 1367 150000 SH DFND 1,2 150000 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 4412 385301 SH DFND 1,2 385301 0 0 EVOKE PHARMA INC COM 30049G104 1550 500000 SH DFND 1,2 500000 0 0 FACEBOOK INC CL A 30303M102 2570 18092 SH DFND 18092 0 0 FIBROGEN INC COM 31572Q808 4085 165700 SH DFND 1,2 165700 0 0 FIVE PRIME THERAPEUTICS INC COM 33830X104 1446 40000 SH DFND 1,2 40000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 1198 242000 SH DFND 1,2 242000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 2328 108023 SH DFND 1,2 108023 0 0 GENOCEA BIOSCIENCES INC COM 372427104 3936 646273 SH DFND 1,2 646273 0 0 GLYCOMIMETICS INC COM 38000Q102 4213 775796 SH DFND 1,2 775796 0 0 HERON THERAPEUTICS INC COM 427746102 3750 250000 SH DFND 1,2 250000 0 0 HORIZON PHARMA PLC SHS G4617B105 7094 480000 SH DFND 1,2 480000 0 0 IMMUNOMEDICS INC COM 452907108 6147 950000 SH DFND 1,2 950000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 804 401764 SH DFND 1,2 401764 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 1697 15000 SH DFND 1,2 15000 0 0 ISHARES TR PUT 464287955 6953 500 SH Put DFND 500 0 0 ISHARES TR CALL 464287905 1391 100 SH Call DFND 0 0 0 ITURAN LOCATION AND CONTROL SHS M6158M104 8680 281356 SH DFND 281356 0 0 KITE PHARMA INC COM 49803L109 2747 35000 SH DFND 1,2 35000 0 0 KORNIT DIGITAL LTD SHS M6372Q113 17 900 SH DFND 900 0 0 LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 3284 110000 SH DFND 1,2 110000 0 0 LOWES COS INC COM 548661107 214 2600 SH DFND 2600 0 0 MACROGENICS INC COM 556099109 1510 81200 SH DFND 1,2 81200 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 2357 1331421 SH DFND 1,2 1331421 0 0 MASTERCARD INCORPORATED CL A 57636Q104 1296 11525 SH DFND 11525 0 0 MERCK & CO INC COM 58933Y105 18744 295000 SH DFND 1,2 295000 0 0 MOHAWK INDS INC COM 608190104 252 1100 SH DFND 1100 0 0 NEUROCRINE BIOSCIENCES INC PUT 64125C959 8010 1500 SH Put DFND 1,2 1500 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 6495 150000 SH DFND 1,2 150000 0 0 NICE LTD SPONSORED ADR 653656108 4318 63520 SH DFND 63520 0 0 NOVARTIS A G SPONSORED ADR 66987V109 18959 255000 SH DFND 1,2 255000 0 0 OBSEVA SA COM H5861P103 2197 211086 SH DFND 1,2 211086 0 0 ORBOTECH LTD ORD M75253100 5066 157096 SH DFND 157096 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 952 2906037 SH DFND 1,2 2906037 0 0 PARATEK PHARMACEUTICALS INC COM 699374302 2695 140000 SH DFND 1,2 140000 0 0 PFIZER INC COM 717081103 13342 390000 SH DFND 1,2 390000 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 2600 1000000 SH DFND 1,2 1000000 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 1650 330000 SH DFND 1,2 330000 0 0 PROSHARES TR PSHS ULTSH 20YRS 74347B201 2189 55950 SH DFND 55950 0 0 RA PHARMACEUTICALS INC COM 74933V108 1277 60000 SH DFND 1,2 60000 0 0 REPROS THERAPEUTICS INC COM NEW 76028H209 935 778800 SH DFND 1,2 778800 0 0 RETROPHIN INC COM 761299106 3861 209131 SH DFND 1,2 209131 0 0 SAGE THERAPEUTICS INC COM 78667J108 3554 50000 SH DFND 1,2 50000 0 0 SAPIENS INTL CORP N V SHS NEW N7716A151 1897 147306 SH DFND 147306 0 0 SAREPTA THERAPEUTICS INC COM 803607100 14298 483047 SH DFND 1,2 483047 0 0 SCHLUMBERGER LTD COM 806857108 2727 34911 SH DFND 34911 0 0 SEALED AIR CORP NEW COM 81211K100 196 4500 SH DFND 4500 0 0 SEATTLE GENETICS INC COM 812578102 2263 36000 SH DFND 1,2 36000 0 0 SELECTA BIOSCIENCES INC COM 816212104 3273 228534 SH DFND 1,2 228534 0 0 SERVICEMASTER GLOBAL HLDGS I COM 81761R109 209 5000 SH DFND 5000 0 0 SHIRE PLC SPONSORED ADR 82481R106 15424 214539 SH DFND 1,2 214539 0 0 SNAP ON INC COM 833034101 2664 15797 SH DFND 15797 0 0 SOLAREDGE TECHNOLOGIES INC COM 83417M104 729 46750 SH DFND 46750 0 0 SPDR S&P 500 ETF TR PUT 78462F953 23808 1000 SH Put DFND 1000 0 0 SPDR SERIES TRUST PUT 78464A950 57152 8000 SH Put DFND 1,2 8000 0 0 STARBUCKS CORP COM 855244109 2723 46631 SH DFND 46631 0 0 STEMLINE THERAPEUTICS INC COM 85858C107 2565 300000 SH DFND 1,2 300000 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 1967 147450 SH DFND 1,2 147450 0 0 SUNESIS PHARMACEUTICALS INC COM PAR 867328700 513 125000 SH DFND 1,2 125000 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 2282 166310 SH DFND 1,2 166310 0 0 TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 3800 6585 SH DFND 6585 0 0 TEVA PHARMACEUTICAL INDS LTD CALL 881624909 4737 1500 SH Call DFND 0 0 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 5519 172000 SH DFND 1,2 172000 0 0 THERAPEUTICSMD INC COM 88338N107 4176 580000 SH DFND 1,2 580000 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 1062 6913 SH DFND 6913 0 0 TJX COS INC NEW COM 872540109 1795 22700 SH DFND 22700 0 0 TOWER SEMICONDUCTOR LTD SHS NEW M87915274 1548 67155 SH DFND 67155 0 0 TREVENA INC COM 89532E109 429 116800 SH DFND 1,2 116800 0 0 TRIPADVISOR INC COM 896945201 173 4000 SH DFND 4000 0 0 ULTIMATE SOFTWARE GROUP INC COM 90385D107 156 800 SH DFND 800 0 0 UNION PAC CORP COM 907818108 3037 28670 SH DFND 28670 0 0 UNITEDHEALTH GROUP INC COM 91324P102 328 2000 SH DFND 2000 0 0 VERSARTIS INC COM 92529L102 6405 300000 SH DFND 1,2 300000 0 0 VISA INC COM CL A 92826C839 4706 52951 SH DFND 52951 0 0 VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1066 544100 SH DFND 1,2 544100 0 0 VTV THERAPEUTICS INC CL A 918385105 1965 300000 SH DFND 1,2 300000 0 0 XENON PHARMACEUTICALS INC COM 98420N105 1312 328029 SH DFND 1,2 328029 0 0 ZOGENIX INC COM NEW 98978L204 1085 100000 SH DFND 1,2 100000 0 0 ZYNERBA PHARMACEUTICALS INC COM 98986X109 2010 100000 SH DFND 1,2 100000 0 0