Partner

0001178913-17-000411.txt : 20170213 0001178913-17-000411.hdr.sgml : 20170213 20170213084417 ACCESSION NUMBER: 0001178913-17-000411 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20161231 FILED AS OF DATE: 20170213 DATE AS OF CHANGE: 20170213 EFFECTIVENESS DATE: 20170213 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 17596069 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 12-31-2016 12-31-2016 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 02-09-2017 2 104 395050 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ACCELERON PHARMA INC COM 00434H108 2552 100000 SH DFND 1,2 100000 0 0 ACHAOGEN INC COM 004449104 6697 514342 SH DFND 1,2 514342 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 4563 270000 SH DFND 1,2 270000 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 2716 16059 SH DFND 16059 0 0 AEVI GENOMIC MEDICINE INC COM 00835P105 2331 450000 SH DFND 1,2 450000 0 0 AIR PRODS & CHEMS INC COM 009158106 3044 21165 SH DFND 21165 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 1971 368500 SH DFND 1,2 368500 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 13826 113000 SH DFND 1,2 113000 0 0 ALPHABET INC CAP STK CL A 02079K305 4555 5748 SH DFND 5748 0 0 AMICUS THERAPEUTICS INC COM 03152W109 3628 730000 SH DFND 1,2 730000 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 54 22000 SH DFND 1,2 22000 0 0 ARDELYX INC COM 039697107 2156 151813 SH DFND 1,2 151813 0 0 ARRAY BIOPHARMA INC COM 04269X105 7911 900000 SH DFND 1,2 900000 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 6611 326622 SH DFND 1,2 326622 0 0 ASTRAZENECA PLC SPONSORED ADR 046353108 1366 50000 SH DFND 1,2 50000 0 0 AVEXIS INC COM 05366U100 2148 45000 SH DFND 1,2 45000 0 0 AXOVANT SCIENCES LTD COM G0750W104 1242 100000 SH DFND 1,2 100000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 3728 45000 SH DFND 1,2 45000 0 0 BOEING CO COM 097023105 1306 8392 SH DFND 8392 0 0 CABLE ONE INC COM 12685J105 311 500 SH DFND 500 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 1400 387943 SH DFND 1,2 387943 0 0 CELGENE CORP COM 151020104 20835 180000 SH DFND 1,2 180000 0 0 CHARTER COMMUNICATIONS INC N CL A 16119P108 4654 16165 SH DFND 16165 0 0 CLEARSIDE BIOMEDICAL INC COM 185063104 2682 300000 SH DFND 1,2 300000 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 1562 27875 SH DFND 27875 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 13031 358000 SH DFND 1,2 358000 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 4579 320229 SH DFND 1,2 320229 0 0 DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 2777 79058 SH DFND 1,2 79058 0 0 EDGE THERAPEUTICS INC COM 279870109 1875 150000 SH DFND 1,2 150000 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 4489 385301 SH DFND 1,2 385301 0 0 FACEBOOK INC CL A 30303M102 1503 13062 SH DFND 13062 0 0 FIBROGEN INC COM 31572Q808 3332 155700 SH DFND 1,2 155700 0 0 FIDELITY NATL INFORMATION SV COM 31620M106 3291 43503 SH DFND 43503 0 0 FIVE PRIME THERAPEUTICS INC COM 33830X104 2004 40000 SH DFND 1,2 40000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 3796 342000 SH DFND 1,2 342000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 1824 121500 SH DFND 1,2 121500 0 0 GENOCEA BIOSCIENCES INC COM 372427104 2869 696273 SH DFND 1,2 696273 0 0 GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 1806 125000 SH DFND 1,2 125000 0 0 GLYCOMIMETICS INC COM 38000Q102 4549 745796 SH DFND 1,2 745796 0 0 HORIZON PHARMA PLC CALL G4617B905 293 18100 SH Call DFND 1,2 0 0 0 HORIZON PHARMA PLC SHS G4617B105 4854 300000 SH DFND 1,2 300000 0 0 IGNYTA INC COM 451731103 117 22065 SH DFND 1,2 22065 0 0 IMMUNE DESIGN CORP COM 45252L103 567 103000 SH DFND 1,2 103000 0 0 IMMUNOMEDICS INC COM 452907108 3854 1050000 SH DFND 1,2 1050000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 2451 401764 SH DFND 1,2 401764 0 0 ISHARES TR PUT 464287958 2682 12000 SH Put DFND 12000 0 0 ISHARES TR PUT 464287955 13485 100000 SH Put DFND 100000 0 0 ISHARES TR CALL 464287903 13485 100000 SH Call DFND 0 0 0 ITURAN LOCATION AND CONTROL SHS M6158M104 8126 306633 SH DFND 306633 0 0 KITE PHARMA INC COM 49803L109 2242 50000 SH DFND 1,2 50000 0 0 LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 888 50677 SH DFND 1,2 50677 0 0 LOWES COS INC COM 548661107 185 2600 SH DFND 2600 0 0 MACROGENICS INC COM 556099109 1660 81200 SH DFND 1,2 81200 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 1354 1340588 SH DFND 1,2 1340588 0 0 MASTERCARD INCORPORATED CL A 57636Q104 1118 10825 SH DFND 10825 0 0 MERCK & CO INC COM 58933Y105 26492 450000 SH DFND 1,2 450000 0 0 MIRATI THERAPEUTICS INC COM 60468T105 383 80528 SH DFND 1,2 80528 0 0 MOHAWK INDS INC COM 608190104 220 1100 SH DFND 1100 0 0 MYOKARDIA INC COM 62857M105 1078 83240 SH DFND 1,2 83240 0 0 NEURODERM LTD ORD SHS M74231107 3906 175951 SH DFND 1,2 175951 0 0 NICE LTD SPONSORED ADR 653656108 2635 38323 SH DFND 38323 0 0 ONCOBIOLOGICS INC COM 68235M105 525 174477 SH DFND 1,2 174477 0 0 ORBOTECH LTD ORD M75253100 1511 45221 SH DFND 45221 0 0 PACIRA PHARMACEUTICALS INC COM 695127100 1615 50000 SH DFND 1,2 50000 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1481 2906037 SH DFND 1,2 2906037 0 0 PALO ALTO NETWORKS INC COM 697435105 882 7052 SH DFND 7052 0 0 PARATEK PHARMACEUTICALS INC COM 699374302 2156 140000 SH DFND 1,2 140000 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 1134 810000 SH DFND 1,2 810000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 2244 100000 SH DFND 1,2 100000 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 980 200000 SH DFND 1,2 200000 0 0 PROSHARES TR PSHS ULTSH 20YRS 74347B201 761 18650 SH DFND 18650 0 0 PTC THERAPEUTICS INC COM 69366J200 1637 150000 SH DFND 1,2 150000 0 0 RA PHARMACEUTICALS INC COM 74933V108 911 60000 SH DFND 1,2 60000 0 0 REPROS THERAPEUTICS INC COM NEW 76028H209 1292 978800 SH DFND 1,2 978800 0 0 RETROPHIN INC COM 761299106 2725 143974 SH DFND 1,2 143974 0 0 SAGE THERAPEUTICS INC COM 78667J108 4595 90000 SH DFND 1,2 90000 0 0 SAPIENS INTL CORP N V SHS NEW N7716A151 1568 109322 SH DFND 109322 0 0 SAREPTA THERAPEUTICS INC COM 803607100 10918 398047 SH DFND 1,2 398047 0 0 SCHLUMBERGER LTD COM 806857108 2885 34361 SH DFND 34361 0 0 SEALED AIR CORP NEW COM 81211K100 159 3500 SH DFND 3500 0 0 SELECTA BIOSCIENCES INC COM 816212104 4605 268534 SH DFND 1,2 268534 0 0 SHIRE PLC SPONSORED ADR 82481R106 5537 32500 SH DFND 1,2 32500 0 0 SITEONE LANDSCAPE SUPPLY INC COM 82982L103 306 8820 SH DFND 8820 0 0 SNAP ON INC COM 833034101 1879 10972 SH DFND 10972 0 0 SOLAREDGE TECHNOLOGIES INC COM 83417M104 325 26203 SH DFND 26203 0 0 SPDR SERIES TRUST PUT 78464A950 32555 550000 SH Put DFND 1,2 550000 0 0 STARBUCKS CORP COM 855244109 2533 45631 SH DFND 45631 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 1262 147450 SH DFND 1,2 147450 0 0 SUNESIS PHARMACEUTICALS INC COM PAR 867328700 453 125000 SH DFND 1,2 125000 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 1192 166310 SH DFND 1,2 166310 0 0 TESARO INC COM 881569107 2690 20000 SH DFND 1,2 20000 0 0 TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 4247 6585 SH DFND 6585 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 18923 522000 SH DFND 1,2 522000 0 0 TEVA PHARMACEUTICAL INDS LTD CALL 881624909 7794 215000 SH Call DFND 0 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 898 6363 SH DFND 6363 0 0 TOWER SEMICONDUCTOR LTD SHS NEW M87915274 1597 83940 SH DFND 83940 0 0 UNION PAC CORP COM 907818108 3740 36076 SH DFND 36076 0 0 UNITEDHEALTH GROUP INC COM 91324P102 272 1700 SH DFND 1700 0 0 VERSARTIS INC COM 92529L102 3725 250000 SH DFND 1,2 250000 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 3315 45000 SH DFND 1,2 45000 0 0 VISA INC COM CL A 92826C839 4053 51951 SH DFND 51951 0 0 VISTAGEN THERAPEUTICS INC COM NEW 92840H202 2029 544100 SH DFND 1,2 544100 0 0 VTV THERAPEUTICS INC CL A 918385105 966 200000 SH DFND 1,2 200000 0 0 XENON PHARMACEUTICALS INC COM 98420N105 2526 328029 SH DFND 1,2 328029 0 0