0001178913-16-006879.txt : 20161114 0001178913-16-006879.hdr.sgml : 20161111 20161114074605 ACCESSION NUMBER: 0001178913-16-006879 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160930 FILED AS OF DATE: 20161114 DATE AS OF CHANGE: 20161114 EFFECTIVENESS DATE: 20161114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 161990587 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 09-30-2016 09-30-2016 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor 972-3-6845520 /s/ Israel Mor Tel Aviv L3 11-13-2016 2 107 614196 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml AC IMMUNE SA SHS H00263105 1314 79800 SH DFND 1,2 79800 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 3976 125000 SH DFND 1,2 125000 0 0 ACHAOGEN INC COM 004449104 6228 1300313 SH DFND 1,2 1300313 0 0 ACORDA THERAPEUTICS INC COM 00484M106 3090 148000 SH DFND 1,2 148000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 4431 270000 SH DFND 1,2 270000 0 0 ADURO BIOTECH INC COM 00739L101 1740 140000 SH DFND 1,2 140000 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 2173 14569 SH DFND 14569 0 0 ADVAXIS INC COM NEW 007624208 2138 200000 SH DFND 1,2 200000 0 0 AIR PRODS & CHEMS INC COM 009158106 3164 21045 SH DFND 21045 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 3687 112500 SH DFND 1,2 112500 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 2893 368500 SH DFND 1,2 368500 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 8578 70000 SH DFND 1,2 70000 0 0 ALIMERA SCIENCES INC COM 016259103 299 200715 SH DFND 1,2 200715 0 0 ALLERGAN PLC SHS G0177J108 16122 70000 SH DFND 1,2 70000 0 0 ALPHABET INC CAP STK CL A 02079K305 3874 4818 SH DFND 4818 0 0 AMGEN INC COM 031162100 10993 65900 SH DFND 1,2 65900 0 0 AMICUS THERAPEUTICS INC COM 03152W109 6697 905000 SH DFND 1,2 905000 0 0 APPLE INC CALL 037833900 2759 18500 SH Call DFND 0 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 1032 300000 SH DFND 1,2 300000 0 0 ARDELYX INC COM 039697107 1964 151813 SH DFND 1,2 151813 0 0 ARRAY BIOPHARMA INC COM 04269X105 6075 900000 SH DFND 1,2 900000 0 0 ARROWHEAD PHARMACEUTICALS IN COM 04280A100 735 100000 SH DFND 1,2 100000 0 0 ASCENDIS PHARMA A S 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