0001178913-16-005416.txt : 20160516 0001178913-16-005416.hdr.sgml : 20160516 20160516061706 ACCESSION NUMBER: 0001178913-16-005416 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20160331 FILED AS OF DATE: 20160516 DATE AS OF CHANGE: 20160516 EFFECTIVENESS DATE: 20160516 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 161650465 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 03-31-2016 03-31-2016 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor 972-3-6845520 /s/ Israel Mor Tel Aviv L3 05-16-2016 2 91 461353 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABEONA THERAPEUTICS INC COM 00289Y107 1198 468050 SH DFND 1,2 468050 0 0 ACADIA PHARMACEUTICALS INC PUT 004225958 2237 80000 SH Put DFND 1,2 80000 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 4194 150000 SH DFND 1,2 150000 0 0 ACORDA THERAPEUTICS INC COM 00484M106 1931 73000 SH DFND 1,2 73000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 3904 270000 SH DFND 1,2 270000 0 0 ADURO BIOTECH INC COM 00739L101 2178 170000 SH DFND 1,2 170000 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 3229 20136 SH DFND 20136 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 2030 50000 SH DFND 1,2 50000 0 0 AIR PRODS & CHEMS INC COM 009158106 2114 14672 SH DFND 14672 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 1531 62500 SH DFND 1,2 62500 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 999 238500 SH DFND 1,2 238500 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 5569 40000 SH DFND 1,2 40000 0 0 ALLERGAN PLC SHS G0177J108 26803 100000 SH DFND 1,2 100000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4394 70000 SH DFND 1,2 70000 0 0 ALPHABET INC CAP STK CL A 02079K305 4333 5680 SH DFND 5680 0 0 AMICUS THERAPEUTICS INC PUT 03152W959 2535 300000 SH Put DFND 1,2 300000 0 0 AMICUS THERAPEUTICS INC COM 03152W109 2535 300000 SH DFND 1,2 300000 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 1877 454500 SH DFND 1,2 454500 0 0 AXSOME THERAPEUTICS INC COM 05464T104 938 109069 SH DFND 1,2 109069 0 0 BIOGEN INC COM 09062X103 30939 118850 SH DFND 1,2 118850 0 0 BLUEBIRD BIO INC COM 09609G100 1275 30000 SH DFND 1,2 30000 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 1159 230041 SH DFND 1,2 230041 0 0 CATALYST PHARMACEUTICALS INC COM 14888U101 1059 905000 SH DFND 1,2 905000 0 0 CELGENE CORP COM 151020104 10009 100000 SH DFND 1,2 100000 0 0 CHARTER COMMUNICATIONS INC D CL A NEW 16117M305 3225 15930 SH DFND 15930 0 0 CHIASMA INC COM 16706W102 2113 230649 SH DFND 1,2 230649 0 0 CLOVIS ONCOLOGY INC COM 189464100 1814 94500 SH DFND 1,2 94500 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 1726 278337 SH DFND 1,2 278337 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 1608 110921 SH DFND 1,2 110921 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 1595 134037 SH DFND 1,2 134037 0 0 CYTOKINETICS INC COM NEW 23282W605 2411 341944 SH DFND 1,2 341944 0 0 DERMIRA INC COM 24983L104 2482 120000 SH DFND 1,2 120000 0 0 EDGE THERAPEUTICS INC COM 279870109 1373 150000 SH DFND 1,2 150000 0 0 EGALET CORP COM 28226B104 2007 292500 SH DFND 1,2 292500 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 2474 147514 SH DFND 1,2 147514 0 0 ELBIT SYS LTD ORD M3760D101 3242 34456 SH DFND 34456 0 0 ELLOMAY CAPITAL LIMITED SHS M39927120 48 5653 SH DFND 5653 0 0 FIVE PRIME THERAPEUTICS INC COM 33830X104 3250 80000 SH DFND 1,2 80000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 2230 342000 SH DFND 1,2 342000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 2066 121500 SH DFND 1,2 121500 0 0 GENOCEA BIOSCIENCES INC COM 372427104 2801 361908 SH DFND 1,2 361908 0 0 GILEAD SCIENCES INC COM 375558103 15864 172700 SH DFND 1,2 172700 0 0 GLYCOMIMETICS INC COM 38000Q102 2014 337911 SH DFND 1,2 337911 0 0 HERON THERAPEUTICS INC COM 427746102 1899 100000 SH DFND 1,2 100000 0 0 IMMUNE DESIGN CORP COM 45252L103 1989 153000 SH DFND 1,2 153000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 1850 250000 SH DFND 1,2 250000 0 0 INTERNET GOLD-GOLDEN LINES L ORD M56595107 678 50250 SH DFND 50250 0 0 IONIS PHARMACEUTICALS INC COM 462222100 1620 40000 SH DFND 1,2 40000 0 0 ISHARES TR PUT 464287955 27658 250000 SH Put DFND 250000 0 0 ISRAEL CHEMICALS LTD SHS M5920A109 1903 437671 SH DFND 437671 0 0 ITURAN LOCATION AND CONTROL SHS M6158M104 9282 471584 SH DFND 471584 0 0 KEMPHARM INC COM 488445107 2667 183954 SH DFND 1,2 183954 0 0 KITE PHARMA INC COM 49803L109 2296 50000 SH DFND 1,2 50000 0 0 MACROGENICS INC COM 556099109 2869 153000 SH DFND 1,2 153000 0 0 MANNKIND CORP CALL 56400P901 746 463600 SH Call DFND 0 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 3071 570908 SH DFND 1,2 570908 0 0 MELLANOX TECHNOLOGIES LTD SHS M51363113 1997 36760 SH DFND 36760 0 0 MYLAN N V SHS EURO N59465109 11588 250000 SH DFND 1,2 250000 0 0 MYLAN N V SHS EURO N59465109 1738 37827 SH DFND 37827 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 2769 70000 SH DFND 1,2 70000 0 0 NEURODERM LTD ORD SHS M74231107 2349 166359 SH DFND 1,2 166359 0 0 NICE SYS LTD SPONSORED ADR 653656108 1769 27300 SH DFND 27300 0 0 NIVALIS THERAPEUTICS INC COM 65481J109 333 79900 SH DFND 1,2 79900 0 0 OCERA THERAPEUTICS INC COM 67552A108 549 186800 SH DFND 1,2 186800 0 0 ORBOTECH LTD ORD M75253100 1563 65710 SH DFND 65710 0 0 ORMAT TECHNOLOGIES INC COM 686688102 13267 322193 SH DFND 322193 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1223 2264426 SH DFND 1,2 2264426 0 0 PALO ALTO NETWORKS INC COM 697435105 2802 17175 SH DFND 17175 0 0 PARTNER COMMUNICATIONS CO LT ADR 70211M109 2909 624230 SH DFND 624230 0 0 PFIZER INC COM 717081103 42285 1426612 SH DFND 1,2 1426612 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 1539 810000 SH DFND 1,2 810000 0 0 PORTOLA PHARMACEUTICALS INC CALL 737010908 1634 80100 SH Call DFND 1,2 0 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 1020 50000 SH DFND 1,2 50000 0 0 PTC THERAPEUTICS INC COM 69366J200 1610 250000 SH DFND 1,2 250000 0 0 RADIUS HEALTH INC COM NEW 750469207 2830 90000 SH DFND 1,2 90000 0 0 RAPTOR PHARMACEUTICAL CORP COM 75382F106 1840 400000 SH DFND 1,2 400000 0 0 SAGE THERAPEUTICS INC COM 78667J108 3943 123000 SH DFND 1,2 123000 0 0 SCYNEXIS INC COM 811292101 1228 304600 SH DFND 1,2 304600 0 0 SELECT SECTOR SPDR TR PUT 81369Y959 50835 750000 SH Put DFND 1,2 750000 0 0 SELECT SECTOR SPDR TR PUT 81369Y955 4500 200000 SH Put DFND 200000 0 0 SHIRE PLC SPONSORED ADR 82481R106 16479 188676 SH DFND 1,2 188676 0 0 STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 277 60718 SH DFND 1,2 60718 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 1392 198863 SH DFND 1,2 198863 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 38805 725200 SH DFND 1,2 725200 0 0 TOBIRA THERAPEUTICS INC COM 88883P101 264 32300 SH DFND 1,2 32300 0 0 TOWER SEMICONDUCTOR LTD SHS NEW M87915274 0 0 SH DFND 0 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1224 132300 SH DFND 1,2 132300 0 0 VALEANT PHARMACEUTICALS INTL COM 91911K102 1802 68500 SH DFND 1,2 68500 0 0 VANDA PHARMACEUTICALS INC COM 921659108 4281 512051 SH DFND 1,2 512051 0 0 VISA INC COM CL A 92826C839 5152 67369 SH DFND 67369 0 0 WABTEC CORP COM 929740108 1721 21704 SH DFND 21704 0 0