Partner

0001178913-16-004256.txt : 20160211 0001178913-16-004256.hdr.sgml : 20160211 20160211094644 ACCESSION NUMBER: 0001178913-16-004256 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20151231 FILED AS OF DATE: 20160211 DATE AS OF CHANGE: 20160211 EFFECTIVENESS DATE: 20160211 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 161408490 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 12-31-2015 12-31-2015 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 02-11-2016 2 119 682986 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABBVIE INC COM 00287Y109 21445 362000 SH DFND 1,2 362000 0 0 ABEONA THERAPEUTICS INC COM 00289Y107 2016 600000 SH DFND 1,2 600000 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 3565 100000 SH DFND 1,2 100000 0 0 ACCELERON PHARMA INC COM 00434H108 2926 60000 SH DFND 1,2 60000 0 0 ACORDA THERAPEUTICS INC COM 00484M106 6118 143000 SH DFND 1,2 143000 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 4248 150000 SH DFND 1,2 150000 0 0 ADURO BIOTECH INC COM 00739L101 3377 120000 SH DFND 1,2 120000 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 2341 15555 SH DFND 15555 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 3246 50000 SH DFND 1,2 50000 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 3716 112500 SH DFND 1,2 112500 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 1617 238500 SH DFND 1,2 238500 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 11286 59164 SH DFND 1,2 59164 0 0 ALLERGAN PLC SHS G0177J108 31250 100000 SH DFND 1,2 100000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3766 40000 SH DFND 1,2 40000 0 0 ANACOR PHARMACEUTICALS INC COM 032420101 3389 30000 SH DFND 1,2 30000 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 2023 454500 SH DFND 1,2 454500 0 0 ARRAY BIOPHARMA INC COM 04269X105 907 215000 SH DFND 1,2 215000 0 0 ARROWHEAD RESH CORP COM NEW 042797209 2989 486000 SH DFND 1,2 486000 0 0 ATYR PHARMA INC COM 002120103 358 36450 SH DFND 1,2 36450 0 0 AXALTA COATING SYS LTD COM G0750C108 1497 56173 SH DFND 56173 0 0 AXSOME THERAPEUTICS INC COM 05464T104 2009 220000 SH DFND 1,2 220000 0 0 BELLICUM PHARMACEUTICALS INC COM 079481107 4693 231515 SH DFND 1,2 231515 0 0 BIOGEN INC COM 09062X103 37941 123850 SH DFND 1,2 123850 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 388 3700 SH DFND 1,2 3700 0 0 BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 2740 193646 SH DFND 1,2 193646 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 8358 121500 SH DFND 1,2 121500 0 0 CARA THERAPEUTICS INC COM 140755109 3335 197820 SH DFND 1,2 197820 0 0 CARBYLAN THERAPEUTICS INC COM 141384107 1303 360000 SH DFND 1,2 360000 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 640 80742 SH DFND 1,2 80742 0 0 CATALYST PHARMACEUTICALS INC COM 14888U101 3565 1455000 SH DFND 1,2 1455000 0 0 CELGENE CORP COM 151020104 17629 147200 SH DFND 1,2 147200 0 0 CELLCOM ISRAEL LTD SHS M2196U109 5144 212300 SH DFND 212300 0 0 CHARTER COMMUNICATIONS INC D CL A NEW 16117M305 737 4026 SH DFND 4026 0 0 CHECK POINT SOFTWARE TECH LT ORD M22465104 4546 55857 SH DFND 55857 0 0 CLOVIS ONCOLOGY INC COM 189464100 3308 94500 SH DFND 1,2 94500 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2197 36600 SH DFND 36600 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 2390 285525 SH DFND 1,2 285525 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 3415 180000 SH DFND 1,2 180000 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 2070 134037 SH DFND 1,2 134037 0 0 DELPHI AUTOMOTIVE PLC SHS G27823106 863 10065 SH DFND 10065 0 0 DIMENSION THERAPEUTICS INC COM 25433V105 2256 200000 SH DFND 1,2 200000 0 0 DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 2174 90000 SH DFND 1,2 90000 0 0 EDGE THERAPEUTICS INC COM 279870109 1938 155000 SH DFND 1,2 155000 0 0 EGALET CORP COM 28226B104 3223 292500 SH DFND 1,2 292500 0 0 ELLOMAY CAPITAL LIMITED SHS M39927120 824 95653 SH DFND 95653 0 0 EXELIXIS INC COM 30161Q104 2538 450000 SH DFND 1,2 450000 0 0 EZCHIP SEMICONDUCTOR LIMITED ORD M4146Y108 505 20447 SH DFND 20447 0 0 FIVE PRIME THERAPEUTICS INC COM 33830X104 6018 145000 SH DFND 1,2 145000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 2774 342000 SH DFND 1,2 342000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 2309 121500 SH DFND 1,2 121500 0 0 GENOCEA BIOSCIENCES INC COM 372427104 2848 540490 SH DFND 1,2 540490 0 0 GENVEC INC COM NEW 37246C307 343 186500 SH DFND 1,2 186500 0 0 GILEAD SCIENCES INC COM 375558103 14440 142700 SH DFND 1,2 142700 0 0 GOOGLE INC CALL 38259P908 3579 4600 SH Call DFND 0 0 0 GOOGLE INC CL A 38259P508 5764 7409 SH DFND 7409 0 0 GW PHARMACEUTICALS PLC CALL 36197T903 3472 50000 SH Call DFND 1,2 0 0 0 GW PHARMACEUTICALS PLC ADS 36197T103 1652 23790 SH DFND 1,2 23790 0 0 HALOZYME THERAPEUTICS INC COM 40637H109 2340 135000 SH DFND 1,2 135000 0 0 HERON THERAPEUTICS INC COM 427746102 3605 135000 SH DFND 1,2 135000 0 0 HONEYWELL INTL INC COM 438516106 2651 25595 SH DFND 25595 0 0 IMMUNE DESIGN CORP COM 45252L103 3072 153000 SH DFND 1,2 153000 0 0 INCYTE CORP COM 45337C102 5598 51621 SH DFND 1,2 51621 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 4079 360000 SH DFND 1,2 360000 0 0 INTRA CELLULAR THERAPIES INC COM 46116X101 2603 48400 SH DFND 1,2 48400 0 0 IONIS PHARMACEUTICALS INC COM 462222100 5029 81200 SH DFND 1,2 81200 0 0 ISRAEL CHEMICALS LTD SHS M5920A109 280 69083 SH DFND 69083 0 0 KEMPHARM INC COM 488445107 3653 183954 SH DFND 1,2 183954 0 0 KITE PHARMA INC COM 49803L109 3081 50000 SH DFND 1,2 50000 0 0 LOXO ONCOLOGY INC COM 548862101 1280 45000 SH DFND 1,2 45000 0 0 MACROGENICS INC COM 556099109 4738 153000 SH DFND 1,2 153000 0 0 MANNKIND CORP CALL 56400P901 1102 760000 SH Call DFND 0 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 4362 570908 SH DFND 1,2 570908 0 0 MASTERCARD INC CL A 57636Q104 2980 30605 SH DFND 30605 0 0 MEDICINES CO COM 584688105 2240 60000 SH DFND 1,2 60000 0 0 MONDELEZ INTL INC CL A 609207105 3077 68625 SH DFND 68625 0 0 MYLAN N V CALL N59465909 16221 300000 SH Call DFND 1,2 0 0 0 NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 1504 157500 SH DFND 1,2 157500 0 0 NIVALIS THERAPEUTICS INC COM 65481J109 1792 231548 SH DFND 1,2 231548 0 0 NOVARTIS A G SPONSORED ADR 66987V109 1549 18000 SH DFND 1,2 18000 0 0 NOVAVAX INC COM 670002104 3356 400000 SH DFND 1,2 400000 0 0 NXP SEMICONDUCTORS N V COM N6596X109 1426 16920 SH DFND 16920 0 0 OCERA THERAPEUTICS INC COM 67552A108 1716 550000 SH DFND 1,2 550000 0 0 OPKO HEALTH INC COM 68375N103 5025 500000 SH DFND 1,2 500000 0 0 ORBOTECH LTD ORD M75253100 3709 167619 SH DFND 167619 0 0 ORMAT TECHNOLOGIES INC COM 686688102 38744 272462 SH DFND 272462 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 2080 3132926 SH DFND 1,2 3132926 0 0 PARTNER COMMUNICATIONS CO LT ADR 70211M109 2700 617951 SH DFND 617951 0 0 PFIZER INC COM 717081103 37981 1176612 SH DFND 1,2 1176612 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 1855 810000 SH DFND 1,2 810000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 4399 85500 SH DFND 1,2 85500 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 1302 150000 SH DFND 1,2 150000 0 0 PTC THERAPEUTICS INC COM 69366J200 2139 66020 SH DFND 1,2 66020 0 0 RADIUS HEALTH INC COM NEW 750469207 4308 70000 SH DFND 1,2 70000 0 0 RAPTOR PHARMACEUTICAL CORP COM 75382F106 3562 685000 SH DFND 1,2 685000 0 0 RETROPHIN INC COM 761299106 2604 135000 SH DFND 1,2 135000 0 0 SAGE THERAPEUTICS INC COM 78667J108 5422 93000 SH DFND 1,2 93000 0 0 SCYNEXIS INC COM 811292101 1892 304600 SH DFND 1,2 304600 0 0 SEATTLE GENETICS INC COM 812578102 3142 70000 SH DFND 1,2 70000 0 0 SHIRE PLC SPONSORED ADR 82481R106 8200 40000 SH DFND 1,2 40000 0 0 SMITH A O COM 831865209 207 2700 SH DFND 2700 0 0 SPDR S&P 500 ETF TR PUT 78462F953 81548 400000 SH Put DFND 1,2 400000 0 0 SPDR SERIES TRUST PUT 78464A950 23152 329800 SH Put DFND 1,2 329800 0 0 STARBUCKS CORP COM 855244109 2811 46828 SH DFND 46828 0 0 STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 1382 181818 SH DFND 1,2 181818 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 2321 202220 SH DFND 1,2 202220 0 0 TESARO INC COM 881569107 1605 30686 SH DFND 1,2 30686 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 7197 109650 SH DFND 109650 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 44320 675200 SH DFND 1,2 675200 0 0 TJX COS INC NEW COM 872540109 3401 47961 SH DFND 47961 0 0 TOBIRA THERAPEUTICS INC COM 88883P101 1886 187622 SH DFND 1,2 187622 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1668 132300 SH DFND 1,2 132300 0 0 UNIQURE NV SHS N90064101 2539 153500 SH DFND 1,2 153500 0 0 VALEANT PHARMACEUTICALS INTL COM 91911K102 3431 33750 SH DFND 1,2 33750 0 0 VANDA PHARMACEUTICALS INC COM 921659108 4302 462051 SH DFND 1,2 462051 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 6090 48400 SH DFND 1,2 48400 0 0 VISA INC COM CL A 92826C839 2838 36600 SH DFND 36600 0 0 VITAE PHARMACEUTICALS INC COM 92847N103 2172 120000 SH DFND 1,2 120000 0 0 WABTEC CORP COM 929740108 908 12761 SH DFND 12761 0 0 WIX COM LTD SHS M98068105 807 35460 SH DFND 35460 0 0