Partner

0001178913-15-003433.txt : 20151116 0001178913-15-003433.hdr.sgml : 20151116 20151116060504 ACCESSION NUMBER: 0001178913-15-003433 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150930 FILED AS OF DATE: 20151116 DATE AS OF CHANGE: 20151116 EFFECTIVENESS DATE: 20151116 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 151231405 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 09-30-2015 09-30-2015 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 11-16-2015 2 128 783788 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABBVIE INC COM 00287Y109 17792 327000 SH DFND 1,2 327000 0 0 ABEONA THERAPEUTICS INC COM 00289Y107 2430 600000 SH DFND 1,2 600000 0 0 ACCELERON PHARMA INC COM 00434H108 2490 100000 SH DFND 1,2 100000 0 0 ACORDA THERAPEUTICS INC COM 00484M106 7158 270000 SH DFND 1,2 270000 0 0 AEGERION PHARMACEUTICALS INC COM 00767E102 2040 150000 SH DFND 1,2 150000 0 0 AIMMUNE THERAPEUTICS INC COM 00900T107 5 200 SH DFND 1,2 200 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 4095 125000 SH DFND 1,2 125000 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 1545 265000 SH DFND 1,2 265000 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 5474 35000 SH DFND 1,2 35000 0 0 ALLERGAN PLC SHS G0177J108 48138 177100 SH DFND 1,2 177100 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3214 40000 SH DFND 1,2 40000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 3386 85230 SH DFND 1,2 85230 0 0 AMGEN INC COM 031162100 6944 50200 SH DFND 1,2 50200 0 0 AMICUS THERAPEUTICS INC COM 03152W109 4337 310000 SH DFND 1,2 310000 0 0 ANACOR PHARMACEUTICALS INC COM 032420101 1177 10000 SH DFND 1,2 10000 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 3075 505000 SH DFND 1,2 505000 0 0 ARRAY BIOPHARMA INC CALL 04269X905 3420 7500 SH Call DFND 1,2 0 0 0 ARRAY BIOPHARMA INC COM 04269X105 1596 350000 SH DFND 1,2 350000 0 0 ARROWHEAD RESH CORP COM NEW 042797209 3110 540000 SH DFND 1,2 540000 0 0 ATYR PHARMA INC COM 002120103 2145 209027 SH DFND 1,2 209027 0 0 BELLICUM PHARMACEUTICALS INC COM 079481107 3364 231514 SH DFND 1,2 231514 0 0 BIOGEN INC COM 09062X103 24804 85000 SH DFND 1,2 85000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 13165 125000 SH DFND 1,2 125000 0 0 BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 2576 196800 SH DFND 1,2 196800 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 8880 150000 SH DFND 1,2 150000 0 0 CARA THERAPEUTICS INC COM 140755109 3141 219800 SH DFND 1,2 219800 0 0 CARBYLAN THERAPEUTICS INC COM 141384107 1428 400000 SH DFND 1,2 400000 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 2595 327476 SH DFND 1,2 327476 0 0 CATALYST PHARMACEUTICALS INC COM 14888U101 3300 1100000 SH DFND 1,2 1100000 0 0 CELGENE CORP COM 151020104 12980 120000 SH DFND 1,2 120000 0 0 CEMPRA INC COM 15130J109 2088 75000 SH DFND 1,2 75000 0 0 CLOVIS ONCOLOGY INC COM 189464100 9656 105000 SH DFND 1,2 105000 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 1228 317250 SH DFND 1,2 317250 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 3754 200000 SH DFND 1,2 200000 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 3059 188930 SH DFND 1,2 188930 0 0 CYTOKINETICS INC COM NEW 23282W605 2490 372250 SH DFND 1,2 372250 0 0 DEPOMED INC COM 249908104 6786 360000 SH DFND 1,2 360000 0 0 DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 2454 100000 SH DFND 1,2 100000 0 0 EGALET CORP COM 28226B104 4284 325000 SH DFND 1,2 325000 0 0 EPIZYME INC COM 29428V104 1929 150000 SH DFND 1,2 150000 0 0 EXELIXIS INC COM 30161Q104 2805 500000 SH DFND 1,2 500000 0 0 FIVE PRIME THERAPEUTICS INC COM 33830X104 2693 175000 SH DFND 1,2 175000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 2785 380000 SH DFND 1,2 380000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 3181 135000 SH DFND 1,2 135000 0 0 GENOCEA BIOSCIENCES INC COM 372427104 2584 377200 SH DFND 1,2 377200 0 0 GENVEC INC COM NEW 37246C307 832 360325 SH DFND 1,2 360325 0 0 GILEAD SCIENCES INC COM 375558103 11783 120000 SH DFND 1,2 120000 0 0 GW PHARMACEUTICALS PLC ADS 36197T103 3938 43100 SH DFND 1,2 43100 0 0 HALOZYME THERAPEUTICS INC COM 40637H109 2015 150000 SH DFND 1,2 150000 0 0 HERON THERAPEUTICS INC COM 427746102 1220 50000 SH DFND 1,2 50000 0 0 HORIZON PHARMA PLC CALL G4617B905 6937 3500 SH Call DFND 1,2 0 0 0 HORIZON PHARMA PLC SHS G4617B105 3964 200000 SH DFND 1,2 200000 0 0 IMMUNE DESIGN CORP COM 45252L103 2074 170000 SH DFND 1,2 170000 0 0 INCYTE CORP COM 45337C102 11033 100000 SH DFND 1,2 100000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 2773 295000 SH DFND 1,2 295000 0 0 INSMED INC COM PAR $.01 457669307 3064 165000 SH DFND 1,2 165000 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 2903 17500 SH DFND 1,2 17500 0 0 INTRA CELLULAR THERAPIES INC COM 46116X101 4220 105400 SH DFND 1,2 105400 0 0 ISHARES TR PUT 464287956 30333 1000 SH Put DFND 1,2 1000 0 0 ISIS PHARMACEUTICALS INC COM 464330109 2749 68000 SH DFND 1,2 68000 0 0 KEMPHARM INC COM 488445107 3961 204393 SH DFND 1,2 204393 0 0 KERYX BIOPHARMACEUTICALS INC COM 492515101 2464 700000 SH DFND 1,2 700000 0 0 KITE PHARMA INC COM 49803L109 3172 56970 SH DFND 1,2 56970 0 0 MACROGENICS INC COM 556099109 3641 170000 SH DFND 1,2 170000 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 1352 162120 SH DFND 1,2 162120 0 0 MIRATI THERAPEUTICS INC COM 60468T105 2754 80000 SH DFND 1,2 80000 0 0 MYLAN N V CALL N59465909 12078 3000 SH Call DFND 1,2 0 0 0 MYLAN N V SHS EURO N59465109 8052 200000 SH DFND 1,2 200000 0 0 NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 1663 175000 SH DFND 1,2 175000 0 0 NEURODERM LTD ORD SHS M74231107 1757 85000 SH DFND 1,2 85000 0 0 NIVALIS THERAPEUTICS INC COM 65481J109 2616 201720 SH DFND 1,2 201720 0 0 NOVARTIS A G SPONSORED ADR 66987V109 1838 20000 SH DFND 1,2 20000 0 0 NOVAVAX INC COM 670002104 1061 150000 SH DFND 1,2 150000 0 0 OCERA THERAPEUTICS INC COM 67552A108 1580 500000 SH DFND 1,2 500000 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 2720 3358483 SH DFND 1,2 3358483 0 0 PFIZER INC COM 717081103 18030 574013 SH DFND 1,2 574013 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 1647 900000 SH DFND 1,2 900000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 4049 95000 SH DFND 1,2 95000 0 0 PROTHENA CORP PLC SHS G72800108 2046 45133 SH DFND 1,2 45133 0 0 PTC THERAPEUTICS INC CALL 69366J900 4272 1600 SH Call DFND 1,2 0 0 0 PTC THERAPEUTICS INC COM 69366J200 107 4000 SH DFND 1,2 4000 0 0 RAPTOR PHARMACEUTICAL CORP COM 75382F106 3534 584089 SH DFND 1,2 584089 0 0 RELYPSA INC COM 759531106 1981 107000 SH DFND 1,2 107000 0 0 RETROPHIN INC COM 761299106 3039 150000 SH DFND 1,2 150000 0 0 SAGE THERAPEUTICS INC COM 78667J108 339 8000 SH DFND 1,2 8000 0 0 SAREPTA THERAPEUTICS INC COM 803607100 1766 55000 SH DFND 1,2 55000 0 0 SCYNEXIS INC COM 811292101 2279 313000 SH DFND 1,2 313000 0 0 SEATTLE GENETICS INC COM 812578102 1928 50000 SH DFND 1,2 50000 0 0 SELECT SECTOR SPDR TR PUT 81369Y959 66230 10000 SH Put DFND 1,2 10000 0 0 SHIRE PLC SPONSORED ADR 82481R106 13252 169751 SH DFND 1,2 169751 0 0 SPARK THERAPEUTICS INC COM 84652J103 2921 70000 SH DFND 1,2 70000 0 0 SPDR SERIES TRUST PUT 78464A950 37350 6000 SH Put DFND 1,2 6000 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 2136 205200 SH DFND 1,2 205200 0 0 TESARO INC COM 881569107 4712 117500 SH DFND 1,2 117500 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 36473 646000 SH DFND 1,2 646000 0 0 THERAPEUTICSMD INC COM 88338N107 3003 512500 SH DFND 1,2 512500 0 0 TOBIRA THERAPEUTICS INC COM 88883P101 1329 137622 SH DFND 1,2 137622 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1915 147000 SH DFND 1,2 147000 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2957 30700 SH DFND 1,2 30700 0 0 UNIQURE NV SHS N90064101 2352 115000 SH DFND 1,2 115000 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 3785 28840 SH DFND 1,2 28840 0 0 VALEANT PHARMACEUTICALS INTL COM 91911K102 2809 15750 SH DFND 1,2 15750 0 0 VANDA PHARMACEUTICALS INC COM 921659108 5791 513390 SH DFND 1,2 513390 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 4166 40000 SH DFND 1,2 40000 0 0 ZAFGEN INC COM 98885E103 1278 40000 SH DFND 1,2 40000 0 0 ZOGENIX INC COM NEW 98978L204 1620 120000 SH DFND 1,2 120000 0 0 AXALTA COATING SYS LTD COM G0750C108 1029 40626 SH DFND 40626 0 0 CELLCOM ISRAEL LTD SHS M2196U109 8793 357452 SH DFND 357452 0 0 CHARTER COMMUNICATIONS INC D CL A NEW 16117M305 708 4026 SH DFND 4026 0 0 CHECK POINT SOFTWARE TECH LT ORD M22465104 5738 72327 SH DFND 72327 0 0 DELPHI AUTOMOTIVE PLC SHS G27823106 696 9150 SH DFND 9150 0 0 ELBIT SYS LTD ORD M3760D101 29169 100618 SH DFND 100618 0 0 ELLOMAY CAPITAL LIMITED SHS M39927120 2335 221097 SH DFND 221097 0 0 MONDELEZ INTL INC CL A 609207105 2490 59475 SH DFND 59475 0 0 NICE SYS LTD SPONSORED ADR 653656108 255 4525 SH DFND 4525 0 0 ORBOTECH LTD ORD M75253100 1213 78482 SH DFND 78482 0 0 ORMAT TECHNOLOGIES INC COM 686688102 17551 132659 SH DFND 132659 0 0 PALO ALTO NETWORKS INC COM 697435105 1720 10002 SH DFND 10002 0 0 PARTNER COMMUNICATIONS CO LT ADR 70211M109 2416 617951 SH DFND 617951 0 0 PERRIGO CO PLC CALL G97822103 8603 547 SH Call DFND 0 0 0 SELECT SECTOR SPDR TR SBI CONS DISCR 81369Y407 6625 89216 SH DFND 89216 0 0 SMITH A O COM 831865209 681 10441 SH DFND 10441 0 0 SPDR S&P 500 ETF TR PUT 78462F953 46969 2451 SH Put DFND 2451 0 0 STARBUCKS CORP COM 855244109 3563 62683 SH DFND 62683 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 6036 106905 SH DFND 106905 0 0 TJX COS INC NEW COM 872540109 2964 41496 SH DFND 41496 0 0 WABTEC CORP COM 929740108 2002 22735 SH DFND 22735 0 0 WIX COM LTD SHS M98068105 1013 58160 SH DFND 58160 0 0