Partner

0001178913-15-002526.txt : 20150806 0001178913-15-002526.hdr.sgml : 20150806 20150806131911 ACCESSION NUMBER: 0001178913-15-002526 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150630 FILED AS OF DATE: 20150806 DATE AS OF CHANGE: 20150806 EFFECTIVENESS DATE: 20150806 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 151032196 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 06-30-2015 06-30-2015 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 08-06-2015 2 133 1020895 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABBVIE INC COM 00287Y109 27346 407000 SH DFND 1,2 407000 0 0 ACCELERON PHARMA INC COM 00434H108 3164 100000 SH DFND 1,2 100000 0 0 ACORDA THERAPEUTICS INC COM 00484M106 5000 150000 SH DFND 1,2 150000 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 6621 125000 SH DFND 1,2 125000 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 2056 265000 SH DFND 1,2 265000 0 0 ALLERGAN PLC SHS G0177J108 53743 177100 SH DFND 1,2 177100 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4435 37000 SH DFND 1,2 37000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 6231 90230 SH DFND 1,2 90230 0 0 AMGEN INC COM 031162100 9242 60200 SH DFND 1,2 60200 0 0 AMICUS THERAPEUTICS INC COM 03152W109 6368 450000 SH DFND 1,2 450000 0 0 APPLE INC COM 037833100 2913 23223 SH DFND 23223 0 0 APPLIED GENETIC TECHNOL CORP COM 03820J100 3070 200124 SH DFND 1,2 200124 0 0 APTOSE BIOSCIENCES INC COM NEW 03835T200 1415 221096 SH DFND 1,2 221096 0 0 ARRAY BIOPHARMA INC COM 04269X105 5768 800000 SH DFND 1,2 800000 0 0 ARROWHEAD RESH CORP COM NEW 042797209 3396 475000 SH DFND 1,2 475000 0 0 ATYR PHARMA INC COM 002120103 3696 209027 SH DFND 1,2 209027 0 0 AURIS MED HLDG AG COM H03579101 316 63967 SH DFND 1,2 63967 0 0 B COMMUNICATIONS LTD SHS M15629104 6448 5977000 SH DFND 5977000 0 0 BELLICUM PHARMACEUTICALS INC COM 079481107 4924 231514 SH DFND 1,2 231514 0 0 BIOGEN INC COM 09062X103 24531 60730 SH DFND 1,2 60730 0 0 BIOMARIN PHARMACEUTICAL INC CALL 09061G901 13678 1000 SH Call DFND 1,2 0 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 8207 60000 SH DFND 1,2 60000 0 0 BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 3930 196800 SH DFND 1,2 196800 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 6654 100000 SH DFND 1,2 100000 0 0 BROADCOM CORP CL A 111320107 1282 24894 SH DFND 24894 0 0 CARA THERAPEUTICS INC COM 140755109 567 46700 SH DFND 1,2 46700 0 0 CARBYLAN THERAPEUTICS INC COM 141384107 2860 400000 SH DFND 1,2 400000 0 0 CATABASIS PHARMACEUTICALS IN COM 14875P107 5060 446036 SH DFND 1,2 446036 0 0 CATALYST PHARMACEUTICALS INC COM 14888U101 4956 1200000 SH DFND 1,2 1200000 0 0 CELGENE CORP COM 151020104 18518 160000 SH DFND 1,2 160000 0 0 CHARTER COMMUNICATIONS INC D CL A NEW 16117M305 1724 10065 SH DFND 10065 0 0 CHECK POINT SOFTWARE TECH LT ORD M22465104 7246 91087 SH DFND 91087 0 0 CLOVIS ONCOLOGY INC COM 189464100 10546 120000 SH DFND 1,2 120000 0 0 COLUCID PHARMACEUTICALS INC COM 19716T101 2824 317250 SH DFND 1,2 317250 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 236 15858 SH DFND 1,2 15858 0 0 CONCORDIA HEALTHCARE CORP COM 206519100 9025 100000 SH DFND 1,2 100000 0 0 CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 5324 316448 SH DFND 1,2 316448 0 0 CYTOKINETICS INC COM NEW 23282W605 2838 422250 SH DFND 1,2 422250 0 0 DELPHI AUTOMOTIVE PLC SHS G27823106 4516 53070 SH DFND 53070 0 0 DEPOMED INC COM 249908104 3863 180000 SH DFND 1,2 180000 0 0 DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3514 150000 SH DFND 1,2 150000 0 0 ELLOMAY CAPITAL LIMITED SHS M39927120 2518 246697 SH DFND 246697 0 0 EXELIXIS INC COM 30161Q104 1504 400000 SH DFND 1,2 400000 0 0 FIVE PRIME THERAPEUTICS INC COM 33830X104 3105 125000 SH DFND 1,2 125000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 3895 380000 SH DFND 1,2 380000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 5708 150000 SH DFND 1,2 150000 0 0 GALECTIN THERAPEUTICS INC COM NEW 363225202 560 205000 SH DFND 1,2 205000 0 0 GENOCEA BIOSCIENCES INC COM 372427104 4149 302200 SH DFND 1,2 302200 0 0 GENVEC INC COM NEW 37246C307 735 360325 SH DFND 1,2 360325 0 0 GILEAD SCIENCES INC COM 375558103 37466 320000 SH DFND 1,2 320000 0 0 GW PHARMACEUTICALS PLC ADS 36197T103 5344 43500 SH DFND 1,2 43500 0 0 HALOZYME THERAPEUTICS INC COM 40637H109 3387 150000 SH DFND 1,2 150000 0 0 IMMUNE DESIGN CORP COM 45252L103 2891 140000 SH DFND 1,2 140000 0 0 IMMUNOMEDICS INC COM 452907108 995 245000 SH DFND 1,2 245000 0 0 IMPAX LABORATORIES INC COM 45256B101 689 15000 SH DFND 1,2 15000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 1862 380000 SH DFND 1,2 380000 0 0 INSMED INC COM PAR $.01 457669307 5250 215000 SH DFND 1,2 215000 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 4224 17500 SH DFND 1,2 17500 0 0 INTRA CELLULAR THERAPIES INC COM 46116X101 4090 128000 SH DFND 1,2 128000 0 0 ISHARES MSCI GERMANY ETF 464286806 5371 192630 SH DFND 192630 0 0 ISHARES TR PUT 464287955 156075 12500 SH Put DFND 1,2 0 0 0 ISHARES TR PUT 464287956 27673 750 SH Put DFND 1,2 0 0 0 ISHARES TR PUT 464287955 17043 1365 SH Put DFND 0 0 0 ISIS PHARMACEUTICALS INC COM 464330109 2762 48000 SH DFND 1,2 48000 0 0 KEMPHARM INC COM 488445107 4363 237500 SH DFND 1,2 237500 0 0 KITE PHARMA INC COM 49803L109 3473 56970 SH DFND 1,2 56970 0 0 LUMENIS LTD SHS CL B M6778Q121 0 245 SH DFND 245 0 0 MACROGENICS INC COM 556099109 3227 85000 SH DFND 1,2 85000 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 3463 298533 SH DFND 1,2 298533 0 0 MEDICINES CO CALL 584688905 2861 1000 SH Call DFND 1,2 0 0 0 MEDICINES CO COM 584688105 5150 180000 SH DFND 1,2 180000 0 0 MEDIVATION INC COM 58501N101 3896 34115 SH DFND 1,2 34115 0 0 MELLANOX TECHNOLOGIES LTD SHS M51363113 3054 62850 SH DFND 62850 0 0 MERCK & CO INC NEW COM 58933Y105 22772 400000 SH DFND 1,2 400000 0 0 MIRATI THERAPEUTICS INC COM 60468T105 2990 95000 SH DFND 1,2 95000 0 0 MYLAN N V SHS EURO N59465109 11876 175000 SH DFND 1,2 175000 0 0 NICE SYS LTD SPONSORED ADR 653656108 1161 18250 SH DFND 18250 0 0 NIVALIS THERAPEUTICS INC COM 65481J109 3863 255000 SH DFND 1,2 255000 0 0 NOVARTIS A G SPONSORED ADR 66987V109 9834 100000 SH DFND 1,2 100000 0 0 OCULAR THERAPEUTIX INC COM 67576A100 3365 160000 SH DFND 1,2 160000 0 0 ORBOTECH LTD ORD M75253100 4470 214922 SH DFND 214922 0 0 ORMAT TECHNOLOGIES INC COM 686688102 11309 80092 SH DFND 80092 0 0 OTONOMY INC COM 68906L105 2598 113000 SH DFND 1,2 113000 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 2261 2540266 SH DFND 1,2 2540266 0 0 PERRIGO CO PLC CALL G97822903 18483 1000 SH Call DFND 1,2 0 0 0 PERRIGO CO PLC SHS G97822103 246 273 SH DFND 273 0 0 PFIZER INC COM 717081103 29306 874013 SH DFND 1,2 874013 0 0 PIERIS PHARMACEUTICALS INC COM 720795103 3300 1200000 SH DFND 1,2 1200000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 3917 86000 SH DFND 1,2 86000 0 0 PROTHENA CORP PLC SHS G72800108 6064 115133 SH DFND 1,2 115133 0 0 PTC THERAPEUTICS INC CALL 69366J900 2888 600 SH Call DFND 1,2 0 0 0 PTC THERAPEUTICS INC COM 69366J200 3201 66500 SH DFND 1,2 66500 0 0 RAPTOR PHARMACEUTICAL CORP COM 75382F106 3261 206500 SH DFND 1,2 206500 0 0 RECEPTOS INC COM 756207106 3801 20000 SH DFND 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205200 0 0 SUNESIS PHARMACEUTICALS INC COM NEW 867328601 3717 1235000 SH DFND 1,2 1235000 0 0 TEKMIRA PHARMACEUTICALS CORP COM NEW 87911B209 3024 255000 SH DFND 1,2 255000 0 0 TESARO INC COM 881569107 5144 87500 SH DFND 1,2 87500 0 0 TETRAPHASE PHARMACEUTICALS I COM 88165N105 2348 49500 SH DFND 1,2 49500 0 0 TEVA PHARMACEUTICAL INDS LTD CALL 881624909 38415 6500 SH Call DFND 1,2 0 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 8865 150000 SH DFND 1,2 150000 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 1613 27300 SH DFND 27300 0 0 THERAPEUTICSMD INC COM 88338N107 3242 412500 SH DFND 1,2 412500 0 0 TOBIRA THERAPEUTICS INC COM 88883P101 2374 137622 SH DFND 1,2 137622 0 0 TOWERS WATSON & CO CL A 891894107 1611 12807 SH DFND 12807 0 0 TRANSITION THERAPEUTICS INC COM NEW 893716209 148 70273 SH DFND 1,2 70273 0 0 TREVENA INC COM 89532E109 2567 410000 SH DFND 1,2 410000 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 3208 147000 SH DFND 1,2 147000 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4884 47700 SH DFND 1,2 47700 0 0 UNIQURE NV SHS N90064101 3105 115000 SH DFND 1,2 115000 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 5017 28840 SH DFND 1,2 28840 0 0 V F CORP COM 918204108 1227 17600 SH DFND 17600 0 0 VALEANT PHARMACEUTICALS INTL COM 91911K102 10163 45750 SH DFND 1,2 45750 0 0 VANDA PHARMACEUTICALS INC COM 921659108 6515 513390 SH DFND 1,2 513390 0 0 VERIFONE SYS INC COM 92342Y109 3160 93055 SH DFND 93055 0 0 VERINT SYS INC COM 92343X100 8470 139434 SH DFND 139434 0 0 WABTEC CORP COM 929740108 2108 22365 SH DFND 22365 0 0 WIX COM LTD SHS M98068105 2842 120305 SH DFND 120305 0 0 ZOSANO PHARMA CORP COM 98979H103 452 62300 SH DFND 1,2 62300 0 0