Partner

0001178913-15-001551.txt : 20150511 0001178913-15-001551.hdr.sgml : 20150511 20150511064314 ACCESSION NUMBER: 0001178913-15-001551 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150331 FILED AS OF DATE: 20150511 DATE AS OF CHANGE: 20150511 EFFECTIVENESS DATE: 20150511 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 15848815 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 03-31-2015 03-31-2015 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 05-10-2015 2 148 960518 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABBVIE INC COM 00287Y109 23826 407000 SH DFND 1,2 407000 0 0 ACHILLION PHARMACEUTICALS IN COM 00448Q201 646 65538 SH DFND 1,2 65538 0 0 ACTAVIS PLC SHS G0083B108 57173 192100 SH DFND 1,2 192100 0 0 AEGERION PHARMACEUTICALS INC COM 00767E102 3140 120000 SH DFND 1,2 120000 0 0 AERIE PHARMACEUTICALS INC COM 00771V108 2821 90000 SH DFND 1,2 90000 0 0 ALCOBRA LTD SHS M2239P109 1 200 SH DFND 1,2 200 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 4329 150000 SH DFND 1,2 150000 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 1194 115000 SH DFND 1,2 115000 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 4333 25000 SH DFND 1,2 25000 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 10945 200230 SH DFND 1,2 200230 0 0 AMGEN INC COM 031162100 19214 120200 SH DFND 1,2 120200 0 0 AMICUS THERAPEUTICS INC COM 03152W109 4896 450000 SH DFND 1,2 450000 0 0 APPLE INC COM 037833100 5317 42733 SH DFND 42733 0 0 APPLIED GENETIC TECHNOL CORP COM 03820J100 4700 235124 SH DFND 1,2 235124 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 3667 445000 SH DFND 1,2 445000 0 0 ARRAY BIOPHARMA INC COM 04269X105 6809 923922 SH DFND 1,2 923922 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1215 70000 SH DFND 1,2 70000 0 0 ASSEMBLY BIOSCIENCES INC COM 045396108 1324 100000 SH DFND 1,2 100000 0 0 ASTRAZENECA PLC SPONSORED ADR 046353108 5929 86637 SH DFND 1,2 86637 0 0 ATARA BIOTHERAPEUTICS INC COM 046513107 2643 63579 SH DFND 1,2 63579 0 0 AURIS MED HLDG AG COM H03579101 997 186300 SH DFND 1,2 186300 0 0 AUSPEX PHARMACEUTICALS INC COM 05211J102 12541 125074 SH DFND 1,2 125074 0 0 AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 2431 60000 SH DFND 1,2 60000 0 0 BELLICUM PHARMACEUTICALS INC COM 079481107 5693 249567 SH DFND 1,2 249567 0 0 BIOGEN INC COM 09062X103 4222 10000 SH DFND 1,2 10000 0 0 BIOLINERX LTD SPONSORED ADR 09071M106 408 193284 SH DFND 1,2 193284 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 9970 80000 SH DFND 1,2 80000 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 6450 100000 SH DFND 1,2 100000 0 0 BROADCOM CORP CL A 111320107 4364 100800 SH DFND 100800 0 0 CATALYST PHARM PARTNERS INC COM 14888U101 4763 1100000 SH DFND 1,2 1100000 0 0 CELGENE CORP COM 151020104 8070 70000 SH DFND 1,2 70000 0 0 CELLDEX THERAPEUTICS INC NEW COM 15117B103 2926 105000 SH DFND 1,2 105000 0 0 CELLECTIS S A SPONSORED ADS 15117K103 1729 50000 SH DFND 1,2 50000 0 0 CHECK POINT SOFTWARE TECH LT ORD M22465104 5896 71927 SH DFND 71927 0 0 CLOVIS ONCOLOGY INC COM 189464100 8348 112455 SH DFND 1,2 112455 0 0 CONATUS PHARMACEUTICALS INC COM 20600T108 1566 220000 SH DFND 1,2 220000 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 5679 375000 SH DFND 1,2 375000 0 0 CVS HEALTH CORP COM 126650100 4362 42260 SH DFND 42260 0 0 CYMABAY THERAPEUTICS INC COM 23257D103 1088 157179 SH DFND 1,2 157179 0 0 DEPOMED INC COM 249908104 4482 200000 SH DFND 1,2 200000 0 0 DYAX CORP COM 26746E103 6158 367556 SH DFND 1,2 367556 0 0 DYAX CORP PUT 26746E953 3351 2000 SH Put DFND 1,2 0 0 0 ELEVEN BIOTHERAPEUTICS INC COM 286221106 777 87110 SH DFND 1,2 87110 0 0 ELLOMAY CAPITAL LIMITED SHS M39927120 1884 221678 SH DFND 221678 0 0 ENDO INTL PLC SHS G30401106 18837 210000 SH DFND 1,2 210000 0 0 EPIZYME INC COM 29428V104 2817 150000 SH DFND 1,2 150000 0 0 ESPERION THERAPEUTICS INC NE COM 29664W105 3334 36000 SH DFND 1,2 36000 0 0 EXELIXIS INC COM 30161Q104 1285 500000 SH DFND 1,2 500000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 1850 200000 SH DFND 1,2 200000 0 0 FORWARD PHARMA A/S SPONSORED ADR 34986J105 5098 180000 SH DFND 1,2 180000 0 0 GALECTIN THERAPEUTICS INC COM NEW 363225202 1508 450000 SH DFND 1,2 450000 0 0 GENOCEA BIOSCIENCES INC COM 372427104 1473 124200 SH DFND 1,2 124200 0 0 GENTHERM INC COM 37253A103 1745 34550 SH DFND 34550 0 0 GENVEC INC COM NEW 37246C307 1559 528325 SH DFND 1,2 528325 0 0 GILEAD SCIENCES INC COM 375558103 31402 320000 SH DFND 1,2 320000 0 0 GW PHARMACEUTICALS PLC ADS 36197T103 3190 35000 SH DFND 1,2 35000 0 0 HERON THERAPEUTICS INC COM 427746102 1163 79900 SH DFND 1,2 79900 0 0 IMMUNE DESIGN CORP COM 45252L103 2732 129440 SH DFND 1,2 129440 0 0 IMMUNOMEDICS INC COM 452907108 1149 300000 SH DFND 1,2 300000 0 0 IMPAX LABORATORIES INC COM 45256B101 4687 100000 SH DFND 1,2 100000 0 0 INOTEK PHARMACEUTICALS CORP COM 45780V102 2168 400000 SH DFND 1,2 400000 0 0 INSMED INC COM PAR $.01 457669307 5200 250000 SH DFND 1,2 250000 0 0 INSYS THERAPEUTICS INC NEW COM NEW 45824V209 5813 100000 SH DFND 1,2 100000 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 4230 15000 SH DFND 1,2 15000 0 0 INTRA CELLULAR THERAPIES INC COM 46116X101 3582 150000 SH DFND 1,2 150000 0 0 ISHARES MSCI GERMANY ETF 464286806 3223 108000 SH DFND 108000 0 0 ISHARES US HOME CONS ETF 464288752 2145 76000 SH DFND 76000 0 0 ISHARES TR PUT 464287956 10303 300 SH Put DFND 1,2 0 0 0 ISHARES TR PUT 464287955 99496 8000 SH Put DFND 1,2 0 0 0 ISHARES TR RUSSELL 2000 ETF 464287655 6977 56100 SH DFND 56100 0 0 JUNO THERAPEUTICS INC COM 48205A109 910 15000 SH DFND 1,2 15000 0 0 KAMADA LTD SHS M6240T109 5167 293727 SH DFND 1,2 293727 0 0 KERYX BIOPHARMACEUTICALS INC COM 492515101 2928 230000 SH DFND 1,2 230000 0 0 KITE PHARMA INC COM 49803L109 3805 65970 SH DFND 1,2 65970 0 0 KYTHERA BIOPHARMACEUTICALS I COM 501570105 4514 90000 SH DFND 1,2 90000 0 0 LUMENIS LTD SHS CL B M6778Q121 0 245 SH DFND 245 0 0 MACROGENICS INC COM 556099109 1882 60000 SH DFND 1,2 60000 0 0 MANNKIND CORP PUT 56400P951 1560 3000 SH Put DFND 1,2 0 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 1920 213533 SH DFND 1,2 213533 0 0 MAST THERAPEUTICS INC COM 576314108 667 1374900 SH DFND 1,2 1374900 0 0 MEDGENICS INC COM NEW 58436Q203 1411 175000 SH DFND 1,2 175000 0 0 MEDICINES CO CALL 584688905 2802 1000 SH Call DFND 1,2 0 0 0 MEDICINES CO COM 584688105 2802 100000 SH DFND 1,2 100000 0 0 MEDIVATION INC COM 58501N101 4661 36115 SH DFND 1,2 36115 0 0 MERCK & CO INC NEW COM 58933Y105 21555 375000 SH DFND 1,2 375000 0 0 MIRATI THERAPEUTICS INC COM 60468T105 2932 100000 SH DFND 1,2 100000 0 0 MYLAN N V SHS EURO N59465109 16149 272100 SH DFND 1,2 272100 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 2978 75000 SH DFND 1,2 75000 0 0 NEWLINK GENETICS CORP COM 651511107 1368 25000 SH DFND 1,2 25000 0 0 NOVARTIS A G SPONSORED ADR 66987V109 9861 100000 SH DFND 1,2 100000 0 0 OCERA THERAPEUTICS INC COM 67552A108 1513 321254 SH DFND 1,2 321254 0 0 OHR PHARMACEUTICAL INC COM NEW 67778H200 476 187500 SH DFND 1,2 187500 0 0 ORBOTECH LTD ORD M75253100 3152 196622 SH DFND 196622 0 0 ORMAT TECHNOLOGIES INC COM 686688102 12054 80092 SH DFND 80092 0 0 OTONOMY INC COM 68906L105 2475 70000 SH DFND 1,2 70000 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1061 1040266 SH DFND 1,2 1040266 0 0 PERRIGO CO PLC SHS G97822103 3046 18400 SH DFND 18400 0 0 PFIZER INC COM 717081103 35625 1024013 SH DFND 1,2 1024013 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 3797 100023 SH DFND 1,2 100023 0 0 PRICELINE GRP INC COM NEW 741503403 2119 1820 SH DFND 1820 0 0 PROTHENA CORP PLC SHS G72800108 3361 88133 SH DFND 1,2 88133 0 0 PTC THERAPEUTICS INC CALL 69366J900 3651 600 SH Call DFND 1,2 0 0 0 PTC THERAPEUTICS INC COM 69366J200 4260 70000 SH DFND 1,2 70000 0 0 PUMA BIOTECHNOLOGY INC COM 74587V107 3257 13796 SH DFND 1,2 13796 0 0 RECEPTOS INC COM 756207106 2886 17500 SH DFND 1,2 17500 0 0 RELYPSA INC COM 759531106 4869 135000 SH DFND 1,2 135000 0 0 RETROPHIN INC COM 761299106 2669 111392 SH DFND 1,2 111392 0 0 SAGE THERAPEUTICS INC COM 78667J108 3301 65724 SH DFND 1,2 65724 0 0 SAGENT PHARMACEUTICALS INC COM 786692103 1163 50000 SH DFND 1,2 50000 0 0 SANGAMO BIOSCIENCES INC COM 800677106 2195 140000 SH DFND 1,2 140000 0 0 SAPIENS INTL CORP N V SHS NEW N7716A151 463 56420 SH DFND 56420 0 0 SEATTLE GENETICS INC COM 812578102 7070 200000 SH DFND 1,2 200000 0 0 SELECT SECTOR SPDR TR PUT 81369Y959 9425 1300 SH Put DFND 1,2 0 0 0 SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 4339 59853 SH DFND 59853 0 0 SHIRE PLC SPONSORED ADR 82481R106 7229 134751 SH DFND 1,2 134751 0 0 SMITH A O COM 831865209 4045 61600 SH DFND 61600 0 0 SNAP ON INC COM 833034101 2256 15340 SH DFND 15340 0 0 SPDR INDEX SHS FDS EURO STOXX 50 78463X202 3649 94000 SH DFND 94000 0 0 SPDR S&P 500 ETF TR PUT 78462F953 72251 3500 SH Put DFND 1,2 0 0 0 SPDR SERIES TRUST PUT 78464A950 33063 1500 SH Put DFND 1,2 0 0 0 SPECTRUM PHARMACEUTICALS INC COM 84763A108 304 50000 SH DFND 1,2 50000 0 0 STARBUCKS CORP COM 855244109 4134 87308 SH DFND 87308 0 0 STEMLINE THERAPEUTICS INC COM 85858C107 1171 80957 SH DFND 1,2 80957 0 0 STERICYCLE INC COM 858912108 2036 14500 SH DFND 14500 0 0 SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 2168 175000 SH DFND 1,2 175000 0 0 SUNESIS PHARMACEUTICALS INC COM NEW 867328601 3185 1300000 SH DFND 1,2 1300000 0 0 TEKMIRA PHARMACEUTICALS CORP COM NEW 87911B209 5212 298486 SH DFND 1,2 298486 0 0 TETRAPHASE PHARMACEUTICALS I COM 88165N105 2748 75000 SH DFND 1,2 75000 0 0 TEVA PHARMACEUTICAL INDS LTD CALL 881624909 21805 3500 SH Call DFND 1,2 0 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 23915 383870 SH DFND 1,2 383870 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 1181 18949 SH DFND 18949 0 0 THERAPEUTICSMD INC COM 88338N107 2208 365000 SH DFND 1,2 365000 0 0 TJX COS INC NEW COM 872540109 3315 47330 SH DFND 47330 0 0 TOKAI PHARMACEUTICALS INC COM 88907J107 1654 146341 SH DFND 1,2 146341 0 0 TOWERS WATSON & CO CL A 891894107 5063 38300 SH DFND 38300 0 0 TRANSITION THERAPEUTICS INC COM NEW 893716209 1864 272906 SH DFND 1,2 272906 0 0 TREVENA INC COM 89532E109 2555 391811 SH DFND 1,2 391811 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1922 95000 SH DFND 1,2 95000 0 0 UNION PAC CORP COM 907818108 1894 17489 SH DFND 17489 0 0 UNIQURE NV SHS N90064101 2491 102415 SH DFND 1,2 102415 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 8422 48840 SH DFND 1,2 48840 0 0 V F CORP COM 918204108 3176 42170 SH DFND 42170 0 0 VALEANT PHARMACEUTICALS INTL COM 91911K102 9087 45750 SH DFND 1,2 45750 0 0 VANDA PHARMACEUTICALS INC COM 921659108 5054 543390 SH DFND 1,2 543390 0 0 VERIFONE SYS INC COM 92342Y109 2636 75545 SH DFND 75545 0 0 VERINT SYS INC COM 92343X100 7574 122304 SH DFND 122304 0 0 WABTEC CORP COM 929740108 2043 21500 SH DFND 21500 0 0 ZOSANO PHARMA CORP COM 98979H103 1866 184619 SH DFND 1,2 184619 0 0