Partner

0001178913-15-000425.txt : 20150212 0001178913-15-000425.hdr.sgml : 20150212 20150212124215 ACCESSION NUMBER: 0001178913-15-000425 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20141231 FILED AS OF DATE: 20150212 DATE AS OF CHANGE: 20150212 EFFECTIVENESS DATE: 20150212 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 15604473 BUSINESS ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 12-31-2014 12-31-2014 false SPHERA FUNDS MANAGEMENT LTD.

Platinum House, 21 Ha'arba'ah Street Tel Aviv L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 02-12-2015 2 128 589980 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml AcelRx Pharmaceuticals Inc COM 00444T100 673 100000 SH DFND 1,2 100000 0 0 Achillion Pharmaceuticals Inc COM 00448Q201 1538 125538 SH DFND 1,2 125538 0 0 Acorda Therapeutics Inc COM 00484M106 3233 79105 SH DFND 1,2 79105 0 0 Actavis plc SHS G0083B108 27569 107100 SH DFND 1,2 107100 0 0 Aegerion Pharmaceuticals Inc COM 00767E102 3350 160000 SH DFND 1,2 160000 0 0 Aerie Pharmaceuticals Inc COM 00771V108 2584 88516 SH DFND 1,2 88516 0 0 Alcobra Ltd SHS M2239P109 144 38500 SH DFND 1,2 38500 0 0 Alder Biopharmaceuticals Inc COM 14339105 2909 100000 SH DFND 1,2 100000 0 0 Allergan Inc/United States CALL 18490902 8238 250000 SH Call DFND 1,2 0 0 0 AMAG Pharmaceuticals Inc COM 00163U106 5337 125230 SH DFND 1,2 125230 0 0 Amgen Inc COM 31162100 1362 8550 SH DFND 1,2 8550 0 0 Amgen Inc CALL 31162900 5457 120200 SH Call DFND 1,2 0 0 0 Amicus Therapeutics Inc COM 03152W109 4576 550000 SH DFND 1,2 550000 0 0 Apple Inc COM 37833100 5828 52803 SH DFND 52803 0 0 Applied Genetic Technologies C COM 03820J100 3471 165124 SH DFND 1,2 165124 0 0 Ardelyx Inc COM 39697107 618 32700 SH DFND 1,2 32700 0 0 Array BioPharma Inc COM 04269X105 4607 973922 SH DFND 1,2 973922 0 0 Arrowhead Research Corp COM NEW 42797209 2952 400000 SH DFND 1,2 400000 0 0 AstraZeneca PLC SPONSORED ADR 46353108 6098 86637 SH DFND 1,2 86637 0 0 Auspex Pharmaceuticals Inc COM 05211J102 5777 110074 SH DFND 1,2 110074 0 0 B Communications Ltd SHS M15629104 2418 134174 SH DFND 134174 0 0 Bellicum Pharmaceuticals COM 79481107 6956 331514 SH DFND 1,2 331514 0 0 Biogen Idec Inc COM 09062X103 13578 40000 SH DFND 1,2 40000 0 0 BioMarin Pharmaceutical Inc COM 09061G101 7232 80000 SH DFND 1,2 80000 0 0 Bristol-Myers Squibb Co COM 110122108 8855 150000 SH DFND 1,2 150000 0 0 Broadcom Corp CL A 111320107 3848 88800 SH DFND 88800 0 0 Catalyst Pharmaceutical Partne COM 14888U101 3148 1060000 SH DFND 1,2 1060000 0 0 Cell Therapeutics Inc COM 12648L106 1770 750000 SH DFND 1,2 750000 0 0 Celladon Corp COM 15117E107 2942 150656 SH DFND 1,2 150656 0 0 Cempra Inc COM 15130J109 2351 100000 SH DFND 1,2 100000 0 0 Check Point Software Technolog COM 162825103 1547 19688 SH DFND 19688 0 0 Clovis Oncology Inc COM 189464100 4589 81955 SH DFND 1,2 81955 0 0 Concert Pharmaceuticals Inc COM 206022105 1998 150000 SH DFND 1,2 150000 0 0 CSX Corp COM 126408103 2161 59648 SH DFND 59648 0 0 CVS Caremark Corp COM 126650100 3526 36610 SH DFND 36610 0 0 Cymabay Therapeutics Inc COM 23257D103 3837 390355 SH DFND 1,2 390355 0 0 Cytokinetics Inc COM NEW 23282W605 3951 493212 SH DFND 1,2 493212 0 0 Dicerna Pharmaceuticals Inc COM 253031108 2912 176802 SH DFND 1,2 176802 0 0 Dyax Corp COM 26746E103 4465 317556 SH DFND 1,2 317556 0 0 Elbit Systems Ltd ORD M3760D101 8853 144759 SH DFND 144759 0 0 Eleven Biotherapeutics Inc COM 286221106 1035 87110 SH DFND 1,2 87110 0 0 Eli Lilly & Co COM 532457108 6009 87100 SH DFND 1,2 87100 0 0 Ellomay Capital Ltd SHS M39927120 1977 203778 SH DFND 203778 0 0 Enanta Pharmaceuticals Inc COM 29251M106 2034 40000 SH DFND 1,2 40000 0 0 Energy Select Sector SPDR Fund PUT 81369Y956 116 50000 SH Put DFND 0 0 0 Express Scripts Holding Co COM 30219G108 2876 33966 SH DFND 33966 0 0 Financial Select Sector SPDR F SBI INT-FINL 81369Y605 5193 210000 SH DFND 210000 0 0 Forward Pharma A/S SPONSORED ADR 34986J105 4166 200000 SH DFND 1,2 200000 0 0 GenVec Inc COM NEW 37246C307 1195 558325 SH DFND 1,2 558325 0 0 Gilead Sciences Inc CALL 375558903 3954 394200 SH Call DFND 1,2 0 0 0 Gilead Sciences Inc COM 375558103 17909 190000 SH DFND 1,2 190000 0 0 GlaxoSmithKline PLC CALL 37733W905 7 291300 SH Call DFND 1,2 0 0 0 GlaxoSmithKline PLC SPONSORED ADR 37733W105 4197 98200 SH DFND 1,2 98200 0 0 Health Care Select Sector SPDR SBI HEALTHCARE 81369Y209 3341 48853 SH DFND 48853 0 0 Ignyta Inc COM 451731103 1227 179055 SH DFND 1,2 179055 0 0 Intercept Pharmaceuticals Inc COM 45845P108 1560 10000 SH DFND 1,2 10000 0 0 iShares Russell 2000 Index Fun RUSSELL 2000 ETF 464287655 6495 54300 SH DFND 54300 0 0 Israel Chemicals Ltd SHS M5920A109 291 40116 SH DFND 40116 0 0 Isramco Negev 2 LP COM NEW 465141406 11134 64958387 SH DFND 64958387 0 0 Ituran Location and Control Lt SHS M6158M104 3714 168203 SH DFND 168203 0 0 Juno Therapeutics Inc COM 48205A109 783 15000 SH DFND 1,2 15000 0 0 KaloBios Pharmaceuticals Inc COM 48344T100 605 349560 SH DFND 1,2 349560 0 0 Kamada Ltd SHS M6240T109 1089 293727 SH DFND 1,2 293727 0 0 Keryx Biopharmaceuticals Inc COM 492515101 2830 200000 SH DFND 1,2 200000 0 0 Kite Pharma Inc COM 49803L109 6400 110970 SH DFND 1,2 110970 0 0 La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 1849 100230 SH DFND 1,2 100230 0 0 MacroGenics Inc COM 556099109 2953 84198 SH DFND 1,2 84198 0 0 Mallinckrodt PLC SHS G5785G107 9006 90940 SH DFND 1,2 90940 0 0 MannKind Corp PUT 56400P951 1155 300000 SH Put DFND 1,2 0 0 0 Marinus Pharmaceuticals Inc COM 56854Q101 3094 293533 SH DFND 1,2 293533 0 0 Mast Therapeutics Inc COM 576314108 770 1374900 SH DFND 1,2 1374900 0 0 Medgenics Inc COM NEW 58436Q203 1139 225000 SH DFND 1,2 225000 0 0 Medicines Co/The COM 584688105 2767 100000 SH DFND 1,2 100000 0 0 Medivation Inc COM 58501N101 5291 53115 SH DFND 1,2 53115 0 0 Mellanox Technologies Ltd SHS M51363113 535 12517 SH DFND 12517 0 0 Merck & Co Inc COM 058933Y10 9514 167530 SH DFND 1,2 167530 0 0 Mylan Inc/PA COM 628530107 5474 97100 SH DFND 1,2 97100 0 0 Neurocrine Biosciences Inc COM 64125C109 1117 50000 SH DFND 1,2 50000 0 0 NewLink Genetics Corp COM 651511107 994 25000 SH DFND 1,2 25000 0 0 NICE Systems Ltd SPONSORED ADR 653656108 2008 39652 SH DFND 39652 0 0 Novartis AG SPONSORED ADR 66987V109 36821 396181 SH DFND 1,2 396181 0 0 Novartis AG SPONSORED ADR 66987V109 4025 43440 SH DFND 43440 0 0 Novavax Inc COM 670002104 9 1543 SH DFND 1,2 1543 0 0 NPS Pharmaceuticals Inc COM 62936P103 2862 80000 SH DFND 1,2 80000 0 0 Ocera Therapeutics Inc COM 67552A108 2683 421254 SH DFND 1,2 421254 0 0 Oncothyreon Inc COM 682324108 813 428000 SH DFND 1,2 428000 0 0 Orbotech Ltd ORD M75253100 4157 280872 SH DFND 280872 0 0 Ormat Industries COM 686688102 2132 309000 SH DFND 309000 0 0 Palatin Technologies Inc COM PAR $ .01 696077403 759 1040266 SH DFND 1,2 1040266 0 0 Pfizer Inc COM 717081103 27226 874013 SH DFND 1,2 874013 0 0 Pharmacyclics Inc COM 716933106 5971 48840 SH DFND 1,2 48840 0 0 Portola Pharmaceuticals Inc COM 737010108 1982 70000 SH DFND 1,2 70000 0 0 ProQR Therapeutics BV SHS EURO N71542109 2817 130000 SH DFND 1,2 130000 0 0 Prothena Corp PLC SHS G72800108 1300 62632 SH DFND 1,2 62632 0 0 PTC Therapeutics Inc COM 69366J200 5695 110000 SH DFND 1,2 110000 0 0 Puma Biotechnology Inc COM 74587V107 3841 20296 SH DFND 1,2 20296 0 0 Receptos Inc COM 756207106 3675 30000 SH DFND 1,2 30000 0 0 Relypsa Inc COM 759531106 3915 127100 SH DFND 1,2 127100 0 0 Repros Therapeutics Inc COM NEW 76028H209 997 100000 SH DFND 1,2 100000 0 0 SAGE Therapeutics Inc COM 78667J108 2918 79724 SH DFND 1,2 79724 0 0 SALIX PHARMACEUTICALS LT COM 795435106 18218 158500 SH DFND 1,2 158500 0 0 Sangamo Biosciences Inc COM 800677106 3042 200000 SH DFND 1,2 200000 0 0 Sanofi RIGHT 12/31/2020 80105N113 6222 67960 SH DFND 1,2 67960 0 0 Sarepta Therapeutics Inc COM 803607100 2532 175000 SH DFND 1,2 175000 0 0 Shire PLC SPONSORED ADR 82481R106 15886 224751 SH DFND 1,2 224751 0 0 Snap-on Inc COM 833034101 2891 21140 SH DFND 21140 0 0 Starbucks Corp COM 855244109 1969 24000 SH DFND 24000 0 0 Tekmira Pharmaceuticals Corp COM NEW 87911B209 2651 175000 SH DFND 1,2 175000 0 0 Teva Pharmaceutical Industries CALL 881624909 1461 194200 SH Call DFND 1,2 0 0 0 Teva Pharmaceutical Industries ADR 881624209 21979 382170 SH DFND 1,2 382170 0 0 Teva Pharmaceutical Industries CALL 881624909 340 270000 SH Call DFND 0 0 0 Teva Pharmaceutical Industries ADR 881624209 811 14099 SH DFND 14099 0 0 TJX Cos Inc COM 872540109 4638 67630 SH DFND 67630 0 0 Tokai Pharmaceuticals Inc COM 88907J107 2268 153841 SH DFND 1,2 153841 0 0 Towers Watson & Co CL A 891894107 4793 42350 SH DFND 42350 0 0 Trevena Inc COM 89532E109 3288 549811 SH DFND 1,2 549811 0 0 Union Pacific Corp COM 907818108 3060 25689 SH DFND 25689 0 0 uniQure B.V. SHS N90064101 2494 168415 SH DFND 1,2 168415 0 0 United Therapeutics Corp COM 91307C102 9562 73840 SH DFND 1,2 73840 0 0 Valeant Pharmaceuticals Intern CALL 91911K902 1395 97200 SH Call DFND 1,2 0 0 0 Valeant Pharmaceuticals Intern COM 91911K102 14103 98550 SH DFND 1,2 98550 0 0 Vanda Pharmaceuticals Inc COM 921659108 5275 368390 SH DFND 1,2 368390 0 0 Verint Systems Inc COM 92343X100 8515 146108 SH DFND 146108 0 0 Vertex Pharmaceuticals Inc COM 92532F100 3564 30000 SH DFND 1,2 30000 0 0 Vital Therapies Inc COM 92847R104 2042 81900 SH DFND 1,2 81900 0 0 Wix.com Ltd SHS M98068105 1241 59108 SH DFND 59108 0 0 Zafgen Inc COM 98885E103 2224 72100 SH DFND 1,2 72100 0 0 ZS Pharma Inc COM 98979G105 860 20682 SH DFND 1,2 20682 0 0