Partner

0001178913-14-003523.txt : 20141113 0001178913-14-003523.hdr.sgml : 20141113 20141113112512 ACCESSION NUMBER: 0001178913-14-003523 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20140930 FILED AS OF DATE: 20141113 DATE AS OF CHANGE: 20141113 EFFECTIVENESS DATE: 20141113 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 141216936 BUSINESS ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 09-30-2014 09-30-2014 false SPHERA FUNDS MANAGEMENT LTD.

Platinum House, 21 Ha'arba'ah Street Tel Aviv L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 11-13-2014 2 132 549444 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABBVIE INC COM 00287Y109 19713 341300 SH DFND 1,2 341300 0 0 ABBVIE INC COM 00287Y109 360 62250 SH DFND 62250 0 0 ACCELERON PHARMA INC COM 00434H108 3024 100000 SH DFND 1,2 100000 0 0 ACELRX PHARMACEUTICALS INC COM 00444T100 1591 289849 SH DFND 1,2 289849 0 0 ACORDA THERAPEUTICS INC COM 00484M106 6746 199105 SH DFND 1,2 199105 0 0 ACTAVIS PLC SHS G0083B108 29460 122100 SH DFND 1,2 122100 0 0 ACTINIUM PHARMACEUTICALS INC COM 00507W107 1952 291300 SH DFND 1,2 291300 0 0 AERIE PHARMACEUTICALS INC COM 00771V108 3383 163516 SH DFND 1,2 163516 0 0 AFFIMED NV COM N01045108 945 150000 SH DFND 1,2 150000 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 25 405 SH DFND 1,2 405 0 0 AKEBIA THERAPEUTICS INC COM 00972D105 1988 89817 SH DFND 1,2 89817 0 0 ALCOBRA LTD CALL M2239P909 264 561 SH Call DFND 1,2 0 0 0 ALDER BIOPHARMACEUTICALS INC COM 14339105 1902 150000 SH DFND 1,2 150000 0 0 ALLERGAN INC COM 18490102 22958 128840 SH DFND 1,2 128840 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 4794 150230 SH DFND 1,2 150230 0 0 AMGEN INC COM 31162100 6819 48550 SH DFND 1,2 48550 0 0 Apple Inc COM 37833100 504 50045 SH DFND 50045 0 0 APPLIED GENETIC TECHNOLOGIES COM 03820J100 3922 210724 SH DFND 1,2 210724 0 0 ARENA PHARMACEUTICALS INC COM 40047102 2095 500000 SH DFND 1,2 500000 0 0 ARRAY BIOPHARMA INC COM 04269X105 3120 873922 SH DFND 1,2 873922 0 0 ASTRAZENECA PLC-SPONS ADR SPONSORED ADR 46353108 8573 120000 SH DFND 1,2 120000 0 0 ASTRAZENECA PLC-SPONS ADR CALL 46353908 306 971 SH Call DFND 1,2 0 0 0 AURIS MEDICAL AG COM H03579101 1111 191300 SH DFND 1,2 191300 0 0 AUSPEX PHARMACEUTICALS INC COM 05211J102 4237 165074 SH DFND 1,2 165074 0 0 AUXILIUM PHARMACEUTICALS INC COM 05334D107 30 1000 SH DFND 1,2 1000 0 0 AVANIR PHARMACEUTICALS INC-A CL A NEW 05348P401 2980 250000 SH DFND 1,2 250000 0 0 B Communications Ltd SHS M15629104 2275 321431 SH DFND 321431 0 0 BIO BLAST PHARMA LTD SHS M20156101 1091 150000 SH DFND 1,2 150000 0 0 BIOLINERX LTD-SPONS ADR SPONSORED ADR 09071M106 298 193284 SH DFND 1,2 193284 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 8801 121970 SH DFND 1,2 121970 0 0 BLUEBIRD BIO INC COM 09609G100 1916 53405 SH DFND 1,2 53405 0 0 BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 265 63331 SH DFND 1,2 63331 0 0 Broadcom Corp CL A 111320107 402 99360 SH DFND 99360 0 0 CATALYST PHARMACEUTICAL PART COM 14888U101 2276 685500 SH DFND 1,2 685500 0 0 CELLADON CORP COM 15117E107 1942 185656 SH DFND 1,2 185656 0 0 CLOVIS ONCOLOGY INC COM 189464100 4625 101955 SH DFND 1,2 101955 0 0 Colgate-Palmolive Co COM 194162103 262 40099 SH DFND 40099 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 286 22700 SH DFND 1,2 22700 0 0 CSX Corp COM 126408103 448 139675 SH DFND 139675 0 0 CVS Caremark Corp COM 126650100 317 39810 SH DFND 39810 0 0 CYMABAY THERAPEUTICS INC COM 23257D103 3354 490355 SH DFND 1,2 490355 0 0 CYTOKINETICS INC COM NEW 23282W605 1279 363212 SH DFND 1,2 363212 0 0 DISCOVERY LABORATORIES INC COM NEW 254668403 893 485500 SH DFND 1,2 485500 0 0 DYAX CORP COM 26746E103 5238 517556 SH DFND 1,2 517556 0 0 Elbit Systems Ltd ORD M3760D101 3306 144759 SH DFND 144759 0 0 ELI LILLY & CO COM 532457108 6297 97100 SH DFND 1,2 97100 0 0 Ellomay Capital Ltd SHS M39927120 244 191202 SH DFND 191202 0 0 EPIZYME INC COM 29428V104 1356 50000 SH DFND 1,2 50000 0 0 GENVEC INC COM NEW 37246C307 1161 558325 SH DFND 1,2 558325 0 0 GILEAD SCIENCES INC CALL 375558903 5765 1942 SH Call DFND 1,2 0 0 0 GLAXOSMITHKLINE PLC-SPON ADR SPONSORED ADR 37733W105 4464 97100 SH DFND 1,2 97100 0 0 GLAXOSMITHKLINE PLC-SPON ADR CALL 37733W905 44 2913 SH Call DFND 1,2 0 0 0 Google Inc CL C 38259P706 262 4540 SH DFND 4540 0 0 Google Inc CL A 38259P508 223 3784 SH DFND 3784 0 0 Health Care Select Sector SPDR PUT 81369Y959 595 4855 SH Put DFND 1,2 4855 0 0 Health Care Select Sector SPDR SBI HEALTHCARE 81369Y209 312 48853 SH DFND 48853 0 0 IGNYTA INC COM 451731103 1604 199055 SH DFND 1,2 199055 0 0 IMMUNOMEDICS INC COM 452907108 1987 534050 SH DFND 1,2 534050 0 0 INCYTE CORP COM 45337C102 3001 61173 SH DFND 1,2 61173 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 3447 14565 SH DFND 1,2 14565 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2516 194200 SH DFND 1,2 194200 0 0 Israel Chemicals Ltd SHS M5920A109 998 1380000 SH DFND 1380000 0 0 Isramco Negev 2 LP COM NEW 465141406 8156 103111944 SH DFND 103111944 0 0 Ituran Location and Control Lt SHS M6158M104 1791 231115 SH DFND 231115 0 0 JOHNSON & JOHNSON COM 478160104 22107 207406 SH DFND 1,2 207406 0 0 KALOBIOS PHARMACEUTICALS INC COM 48344T100 542 349560 SH DFND 1,2 349560 0 0 KITE PHARMA INC COM 49803L109 1937 67970 SH DFND 1,2 67970 0 0 LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 2146 223330 SH DFND 1,2 223330 0 0 MACROCURE LTD SHS M67872107 51 7100 SH DFND 1,2 7100 0 0 MACROGENICS INC COM 556099109 2253 107781 SH DFND 1,2 107781 0 0 MALLINCKRODT PLC SHS G5785G107 12255 135940 SH DFND 1,2 135940 0 0 Mankind Corp PUT 56400P951 998 3000 SH Put DFND 1,2 3000 0 0 MARINUS PHARMACEUTICALS INC COM 56854Q101 1899 293533 SH DFND 1,2 293533 0 0 MasterCard Inc CL A 57636Q104 192 26000 SH DFND 26000 0 0 MEDA AB-A SHS COM 584045108 6103 433889 SH DFND 1,2 433889 0 0 MEDIVATION INC COM 58501N101 6240 63115 SH DFND 1,2 63115 0 0 MERCK & CO. INC. COM 58933Y105 24751 417530 SH DFND 1,2 417530 0 0 MYLAN INC COM 628530107 4417 97100 SH DFND 1,2 97100 0 0 NICE Systems Ltd SPONSORED ADR 653656108 664 64542 SH DFND 64542 0 0 Novartis AG SPONSORED ADR 66987V109 308 32740 SH DFND 32740 0 0 NOVARTIS AG-REG SPONSORED ADR 66987V109 42097 446181 SH DFND 1,2 446181 0 0 NPS PHARMACEUTICALS INC COM 62936P103 3625 139420 SH DFND 1,2 139420 0 0 OCERA THERAPEUTICS INC COM 67552A108 1574 321254 SH DFND 1,2 321254 0 0 ONCOMED PHARMACEUTICALS INC COM 68234X102 1838 97100 SH DFND 1,2 97100 0 0 ONCOTHYREON INC COM 682324108 822 428000 SH DFND 1,2 428000 0 0 Orbotech Ltd ORD M75253100 890 571532 SH DFND 571532 0 0 Ormat Technologies Inc COM 686688102 52 19889 SH DFND 19889 0 0 OTONOMY INC COM 68906L105 2666 111085 SH DFND 1,2 111085 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1009 1084466 SH DFND 1,2 1084466 0 0 PFIZER INC COM 717081103 37673 1274013 SH DFND 1,2 1274013 0 0 PHARMACYCLICS INC COM 716933106 4561 38840 SH DFND 1,2 38840 0 0 PROQR THERAPEUTICS NV SHS EURO N71542109 3438 200000 SH DFND 1,2 200000 0 0 PROSENSA HOLDING BV SHS USD N71546100 1849 219345 SH DFND 1,2 219345 0 0 PROTHENA CORP PLC SHS G72800108 663 29907 SH DFND 1,2 29907 0 0 PTC THERAPEUTICS INC COM 69366J200 2800 63625 SH DFND 1,2 63625 0 0 PUMA BIOTECHNOLOGY INC COM 74587V107 7228 30296 SH DFND 1,2 30296 0 0 RADIUS HEALTH INC COM NEW 750469207 3150 150000 SH DFND 1,2 150000 0 0 RECEPTOS INC COM 756207106 1553 25000 SH DFND 1,2 25000 0 0 RELYPSA INC COM 759531106 2048 97100 SH DFND 1,2 97100 0 0 SAGE THERAPEUTICS INC COM 78667J108 2770 87924 SH DFND 1,2 87924 0 0 SALIX PHARMACEUTICALS LTD CALL 795435906 1955 485 SH Call DFND 1,2 0 0 0 SALIX PHARMACEUTICALS LTD COM 795435106 3125 20000 SH DFND 1,2 20000 0 0 SANOFI RIGHT 12/31/2020 80105N113 7689 67960 SH DFND 1,2 67960 0 0 Schlumberger Ltd COM 806857108 293 28790 SH DFND 28790 0 0 SEATTLE GENETICS INC COM 812578102 5776 155360 SH DFND 1,2 155360 0 0 SHIRE PLC SPONSORED ADR 82481R106 22429 259085 SH DFND 1,2 259085 0 0 Snap-on Inc COM 833034101 195 16100 SH DFND 16100 0 0 SPDR S&P 500 ETF Trust PUT 78464A950 1580 2000 SH Put DFND 1,2 2000 0 0 STEMCELLS INC COM NEW 85857R204 612 485500 SH DFND 1,2 485500 0 0 SUMMIT CORPORATION PLC COM 86606G101 63 25000 SH DFND 1,2 25000 0 0 TETRALOGIC PHARMACEUTICALS C COM 88165U109 808 194200 SH DFND 1,2 194200 0 0 TETRAPHASE PHARMACEUTICALS I COM 88165N105 47 2365 SH DFND 1,2 2365 0 0 Teva Pharmaceutical Industries CALL 881624909 947 1942 SH Call DFND 1,2 0 0 0 Teva Pharmaceutical Industries ADR 881624209 5398 315268 SH DFND 315268 0 0 Teva Pharmaceutical Industries CALL 881624909 39 1810 SH Call DFND 0 0 0 TEVA PHARMACEUTICAL-SP ADR ADR 881624209 17854 332170 SH DFND 1,2 332170 0 0 TJX Cos Inc COM 872540109 163 27600 SH DFND 27600 0 0 TJX Cos Inc CALL 872540909 22 500 SH Call DFND 0 0 0 TOKAI PHARMACEUTICALS INC COM 88907J107 3482 230000 SH DFND 1,2 230000 0 0 Towers Watson & Co CL A 891894107 279 28000 SH DFND 28000 0 0 TREVENA INC COM 89532E109 2126 331111 SH DFND 1,2 331111 0 0 Union Pacific Corp COM 907818108 350 32312 SH DFND 32312 0 0 UNITED THERAPEUTICS CORP COM 91307C102 11429 88840 SH DFND 1,2 88840 0 0 VALEANT PHARMACEUTICALS INTE CALL 91911K902 1113 972 SH Call DFND 1,2 0 0 0 VALEANT PHARMACEUTICALS INTE COM 91911K102 12930 98550 SH DFND 1,2 98550 0 0 VANDA PHARMACEUTICALS INC COM 921659108 2267 218390 SH DFND 1,2 218390 0 0 Verint Systems Inc COM 92343X100 842 151468 SH DFND 151468 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 16847 150000 SH DFND 1,2 150000 0 0 VF Corp COM 918204108 316 47900 SH DFND 47900 0 0 Yum! Brands Inc COM 988498101 287 39910 SH DFND 39910 0 0 ZAFGEN INC COM 98885E103 1908 97100 SH DFND 1,2 97100 0 0 ZS PHARMA INC COM 98979G105 811 20682 SH DFND 1,2 20682 0 0