Partner

0001178913-14-002610.txt : 20140812 0001178913-14-002610.hdr.sgml : 20140812 20140811091452 ACCESSION NUMBER: 0001178913-14-002610 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20140630 FILED AS OF DATE: 20140811 DATE AS OF CHANGE: 20140811 EFFECTIVENESS DATE: 20140811 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 141029112 BUSINESS ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 06-30-2014 06-30-2014 false SPHERA FUNDS MANAGEMENT LTD.

Platinum House, 21 Ha'arba'ah Street Tel Aviv L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received f the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 08-10-2014 2 105 412400 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml Achillion Pharmaceuticals Inc COM 00448Q201 1136 150000 SH DFND 1,2 150000 0 0 Acorda Therapeutics Inc COM 00484M106 5057 150000 SH DFND 1,2 150000 0 0 Actinium Pharmaceuticals Inc COM 00507W107 2166 300000 SH DFND 1,2 300000 0 0 Aerie Pharmaceuticals Inc COM 00771V108 2725 110000 SH DFND 1,2 110000 0 0 Agios Pharmaceuticals Inc COM 00847X104 1146 25000 SH DFND 1,2 25000 0 0 Akebia Therapeutics Inc COM 00972D105 2015 72500 SH DFND 1,2 72500 0 0 Allergan Inc/United States COM 18490102 6769 40000 SH DFND 1,2 40000 0 0 Ambit Biosciences Corp COM 02318X100 1918 277568 SH DFND 1,2 277568 0 0 Amgen Inc COM 31162100 4735 40000 SH DFND 1,2 40000 0 0 Amgen Inc CALL 31162900 1120 1238 SH Call DFND 1,2 1238 0 0 Ampio Pharmaceuticals Inc COM 03209T109 2605 312000 SH DFND 1,2 312000 0 0 Aquinox Pharmaceuticals Inc COM 03842B101 1780 190000 SH DFND 1,2 190000 0 0 Array BioPharma Inc COM 04269X105 1300 285000 SH DFND 1,2 285000 0 0 Arrowhead Research Corp COM NEW 42797209 1431 100000 SH DFND 1,2 100000 0 0 Auxilium Pharmaceuticals Inc CALL 05334D907 40 935 SH Call DFND 1,2 935 0 0 AVANIR Pharmaceuticals Inc CL A NEW 05348P401 5640 1000000 SH DFND 1,2 1000000 0 0 Biogen Idec Inc COM 09062X103 6937 22000 SH DFND 1,2 22000 0 0 BioLine RX Ltd SPONSORED ADR 09071M106 1248 600000 SH DFND 1,2 600000 0 0 BioMarin Pharmaceutical Inc COM 09061G101 7465 120000 SH DFND 1,2 120000 0 0 Celladon Corp COM 15117E107 2403 150000 SH DFND 1,2 150000 0 0 Clovis Oncology Inc COM 189464100 4348 105000 SH DFND 1,2 105000 0 0 Corium International Inc COM 21887L107 537 69100 SH DFND 1,2 69100 0 0 Cytokinetics Inc COM NEW 23282W605 311 65100 SH DFND 1,2 65100 0 0 CytRx Corp COM PAR $.001 232828509 1672 400000 SH DFND 1,2 400000 0 0 Dipexium Pharmaceuticals Inc COM 25456J104 916 94400 SH DFND 1,2 94400 0 0 Discovery Laboratories Inc COM NEW 254668403 890 500000 SH DFND 1,2 500000 0 0 Dyax Corp COM 26746E103 6240 650000 SH DFND 1,2 650000 0 0 Eli Lilly & Co COM 532457108 6217 100000 SH DFND 1,2 100000 0 0 Epizyme Inc COM 29428V104 3522 113188 SH DFND 1,2 113188 0 0 Galmed Pharmaceuticals Ltd SHS M47238106 1656 170000 SH DFND 1,2 170000 0 0 GenVec Inc COM NEW 37246C307 1478 575000 SH DFND 1,2 575000 0 0 Gilead Sciences Inc COM 375558103 4146 50000 SH DFND 1,2 50000 0 0 Gilead Sciences Inc CALL 375558903 1158 1000 SH Call DFND 1,2 1000 0 0 Gilead Sciences Inc CALL 375558903 850 1000 SH Call DFND 1,2 1000 0 0 GlaxoSmithKline PLC SPONSORED ADR 37733W105 16044 300000 SH DFND 1,2 300000 0 0 GlaxoSmithKline PLC CALL 37733W905 698 3000 SH Call DFND 1,2 3000 0 0 Ignyta Inc COM 451731103 1863 205000 SH DFND 1,2 205000 0 0 Immunomedics Inc COM 452907108 2008 550000 SH DFND 1,2 550000 0 0 Impax Laboratories Inc CALL 45256B901 550 1000 SH Call DFND 1,2 1000 0 0 Incyte Corp Ltd COM 45337C102 4120 73000 SH DFND 1,2 73000 0 0 Insmed Inc COM PAR $.01 457669307 1586 79400 SH DFND 1,2 79400 0 0 Insmed Inc CALL 457669907 293 1000 SH Call DFND 1,2 1000 0 0 Intra-Cellular Therapies Inc COM 46116X101 1590 94300 SH DFND 1,2 94300 0 0 Johnson & Johnson COM 478160104 22347 213600 SH DFND 1,2 213600 0 0 KaloBios Pharmaceuticals Inc COM 48344T100 821 360000 SH DFND 1,2 360000 0 0 MacroGenics Inc COM 556099109 2412 111000 SH DFND 1,2 111000 0 0 Medivation Inc COM 58501N101 5396 70000 SH DFND 1,2 70000 0 0 Merck & Co Inc COM 58933Y105 24876 430000 SH DFND 1,2 430000 0 0 Novartis AG SPONSORED ADR 66987V109 41033 511000 SH DFND 1,2 511000 0 0 NPS Pharmaceuticals Inc COM 62936P103 1619 49000 SH DFND 1,2 49000 0 0 Ocera Therapeutics Inc COM 67552A108 971 127048 SH DFND 1,2 127048 0 0 OncoMed Pharmaceuticals Inc COM 68234X102 1748 75000 SH DFND 1,2 75000 0 0 Oncothyreon Inc COM 682324108 2392 738336 SH DFND 1,2 738336 0 0 Pfizer Inc COM 717081103 19428 654596 SH DFND 1,2 654596 0 0 Pharmacyclics Inc COM 716933106 4486 50000 SH DFND 1,2 50000 0 0 Prosensa Holding BV SHS USD N71546100 1578 125000 SH DFND 1,2 125000 0 0 PTC Therapeutics Inc COM 69366J200 3921 150000 SH DFND 1,2 150000 0 0 Puma Biotechnology Inc COM 74587V107 1650 25000 SH DFND 1,2 25000 0 0 Receptos Inc COM 756207106 2556 60000 SH DFND 1,2 60000 0 0 Redhill Biopharma Ltd SPONSORED ADS 757468103 9243 1546880 SH DFND 1,2 1546880 0 0 RXi Pharmaceuticals Corp COM NEW 74979C303 531 175815 SH DFND 1,2 175815 0 0 SALIX PHARMACEUTICALS LT CALL 795435906 915 500 SH Call DFND 1,2 500 0 0 Sanofi SPONSORED ADR 80105N105 9310 120000 SH DFND 1,2 120000 0 0 Seattle Genetics Inc COM 812578102 11391 297800 SH DFND 1,2 297800 0 0 Shire PLC SPONSORED ADR 82481R106 8226 180000 SH DFND 1,2 180000 0 0 StemCells Inc COM NEW 85857R204 1015 500000 SH DFND 1,2 500000 0 0 Summit Corp PLC COM 86606G101 455 313583 SH DFND 1,2 313583 0 0 TetraLogic Pharmaceuticals Cor COM 88165U109 1178 200000 SH DFND 1,2 200000 0 0 Tetraphase Pharmaceuticals Inc COM 88165N105 2671 198000 SH DFND 1,2 198000 0 0 Teva Pharmaceutical Industries ADR 881624209 18347 350000 SH DFND 1,2 350000 0 0 Teva Pharmaceutical Industries CALL 881624909 970 2000 SH Call DFND 1,2 2000 0 0 TG Therapeutics Inc COM 88322Q108 563 60000 SH DFND 1,2 60000 0 0 Trevena Inc COM 89532E109 1927 341000 SH DFND 1,2 341000 0 0 Vanda Pharmaceuticals Inc COM 921659108 2265 140000 SH DFND 1,2 140000 0 0 Vertex Pharmaceuticals Inc CALL 92532F900 1905 1000 SH Call DFND 1,2 1000 0 0 Vertex Pharmaceuticals Inc PUT 92532F950 13 1500 SH Put DFND 1,2 1500 0 0 AutoNation Inc COM 05329W102 3139 52600 SH DFND 52600 0 0 B Communications Ltd SHS M15629104 16141 241705 SH DFND 241705 0 0 Broadcom Corp CL A 111320107 2937 79120 SH DFND 79120 0 0 Caesarstone Sdot-Yam Ltd ORD SHS M20598104 2925 59600 SH DFND 59600 0 0 Colgate-Palmolive Co COM 194162103 3259 47799 SH DFND 47799 0 0 CSX Corp COM 126408103 4570 148325 SH DFND 148325 0 0 CVS Caremark Corp COM 126650100 1454 19295 SH DFND 19295 0 0 Ellomay Capital Ltd SHS M39927120 660 20564 SH DFND 20564 0 0 Google Inc CL A 38259P508 2212 3784 SH DFND 3784 0 0 Google Inc CL C 38259P706 2612 4540 SH DFND 4540 0 0 Health Care Select Sector SPDR SBI HEALTHCARE 81369Y209 1786 29353 SH DFND 29353 0 0 Lumenis Ltd SHS CL B M6778Q121 0 245 SH DFND 245 0 0 Novartis AG SPONSORED ADR 66987V109 2001 22100 SH DFND 22100 0 0 Orbotech Ltd ORD M75253100 5216 343602 SH DFND 343602 0 0 Ormat Technologies Inc COM 686688102 677 23472 SH DFND 23472 0 0 Penske Automotive Group Inc COM 70959W103 1452 29327 SH DFND 29327 0 0 priceline.com Inc COM NEW 741503403 2324 1932 SH DFND 1932 0 0 Sonic Automotive Inc CL A 83545G102 1334 50000 SH DFND 50000 0 0 SPDR S&P 500 ETF Trust CALL 78462F903 338 1500 SH Call DFND 1500 0 0 Teva Pharmaceutical Industries PUT 881624959 80 1000 SH Put DFND 1000 0 0 Teva Pharmaceutical Industries CALL 881624909 270 1210 SH Call DFND 1210 0 0 Teva Pharmaceutical Industries ADR 881624209 4954 94500 SH DFND 94500 0 0 TJX Cos Inc CALL 872540909 69 500 SH Call DFND 500 0 0 TJX Cos Inc COM 872540109 1377 25916 SH DFND 25916 0 0 TOP Image Systems Ltd ORD M87896102 79 20000 SH DFND 20000 0 0 Towers Watson & Co CL A 891894107 4351 41740 SH DFND 41740 0 0 Verint Systems Inc COM 92343X100 6600 134550 SH DFND 134550 0 0 Walgreen Co COM 931422109 4521 60993 SH DFND 60993 0 0 Yum! Brands Inc COM 988498101 4582 56433 SH DFND 56433 0 0