Partner

0001178913-14-001658.txt : 20140514 0001178913-14-001658.hdr.sgml : 20140514 20140514120237 ACCESSION NUMBER: 0001178913-14-001658 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20140331 FILED AS OF DATE: 20140514 DATE AS OF CHANGE: 20140514 EFFECTIVENESS DATE: 20140514 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 14840130 BUSINESS ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 03-31-2014 03-31-2014 false SPHERA FUNDS MANAGEMENT LTD.

Platinum House, 21 Ha'arba'ah Street Tel Aviv L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received f the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 05-14-2014 2 114 438056 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ALLIANCE DATA SYSTEMS CORP COM 018581108 1252 4596 SH DFND 4596 0 0 BROADCOM CORP-CL A CL A 111320107 3542 112500 SH DFND 112500 0 0 CAESARSTONE SDOT-YAM LTD ORD SHS M20598104 426 7830 SH DFND 7830 0 0 CHECK POINT SOFTWARE TECH ORD M22465104 1793 26513 SH DFND 26513 0 0 COLGATE-PALMOLIVE CO COM 194162103 4074 62799 SH DFND 62799 0 0 COMPUGEN LTD ORD 2620859 726 69109 SH DFND 69109 0 0 COSTCO WHOLESALE CORP COM 22160K105 1721 15409 SH DFND 15409 0 0 CSX CORP COM 126408103 3384 116825 SH DFND 116825 0 0 CVS CAREMARK CORP COM 126650100 2680 35795 SH DFND 35795 0 0 ELLOMAY CAPITAL LTD SHS M39927120 995 100853 SH DFND 100853 0 0 ENERGY SELECT SECTOR SPDR HEDGEFUND SBI INT-ENERGY 81369Y506 3562 40000 SH DFND 40000 0 0 F5 NETWORKS INC COM 315616102 663 6222 SH DFND 6222 0 0 FINANCIAL SELECT SECTOR SPDR HEDGEFUND SBI INT-FINL 81369Y605 15206 680659 SH DFND 680659 0 0 GOOGLE INC-CL A CL A 38259P508 3192 2864 SH DFND 2864 0 0 HEALTH CARE SELECT SECTOR HEDGEFUND SBI HEALTHCARE 81369Y209 9321 159353 SH DFND 159353 0 0 INDUSTRIAL SELECT SECT SPDR HEDGEFUND SBI INT-INDS 81369Y704 2858 54623 SH DFND 54623 0 0 Ishares Russell 2000 Index PUT 464287955 690 3000 SH Put DFND 3000 0 0 LAS VEGAS SANDS CORP COM 517834107 2249 27847 SH DFND 27847 0 0 NCR CORPORATION COM 62886E108 1749 47840 SH DFND 47840 0 0 NIKE INC -CL B CL B 654106103 3659 49544 SH DFND 49544 0 0 NOVA MEASURING INSTRUMENTS US COM M7516K103 2029 181184 SH DFND 181184 0 0 Novartis AG SPONSORED ADR 66987V109 2049 24100 SH DFND 24100 0 0 ORBOTECH LTD ORD M75253100 3435 223174 SH DFND 223174 0 0 ORMAT TECHNOLOGIES INC COM 686688102 704 23472 SH DFND 23472 0 0 PERRIGO CO SHS G97822103 5584 36106 SH DFND 36106 0 0 PRECISION CASTPARTS CORP COM 740189105 3165 12520 SH DFND 12520 0 0 PRICELINE.COM INC COM NEW 741503403 2672 2242 SH DFND 2242 0 0 SCHWAB (CHARLES) CORP COM 808513105 1891 69200 SH DFND 69200 0 0 SILICOM LTD ORD M84116108 1991 32088 SH DFND 32088 0 0 SPDR EURO STOXX 50 ETF HEDGEFUND EURO STOXX 50 78463X202 3541 83000 SH DFND 83000 0 0 STERICYCLE INC COM 858912108 1072 9439 SH DFND 9439 0 0 Teva Pharmaceutical Industries CALL 881624909 1321 1000 SH Call DFND 1000 0 0 Teva Pharmaceutical Industries ADR 881624209 1458 27600 SH DFND 27600 0 0 TJX COMPANIES INC COM 872540109 4544 74916 SH DFND 74916 0 0 WALGREEN CO COM 931422109 3397 51453 SH DFND 51453 0 0 Acceleron Pharma Inc COM 00434H108 690 20000 SH DFND 1,2 20000 0 0 Aerie Pharmaceuticals Inc COM 00771V108 2384 112500 SH DFND 1,2 112500 0 0 Ambit Biosciences Corp COM 02318X100 1354 148468 SH DFND 1,2 148468 0 0 Amgen Inc COM 31162100 8634 70000 SH DFND 1,2 70000 0 0 Ampio Pharmaceuticals Inc COM 03209T109 1429 225000 SH DFND 1,2 225000 0 0 Aquinox Pharmaceuticals Inc COM 03842B101 2419 190000 SH DFND 1,2 190000 0 0 Auxilium Pharmaceuticals Inc CALL 05334D907 332 935 SH Call DFND 1,2 935 0 0 Biodel Inc COM NEW 09064M204 775 283900 SH DFND 1,2 283900 0 0 Biogen Idec Inc COM 09062X103 5200 17000 SH DFND 1,2 17000 0 0 BioLine RX Ltd SPONSORED ADR 09071M106 1338 600000 SH DFND 1,2 600000 0 0 BioMarin Pharmaceutical Inc NOTE 1.875% 4/2 09061GAD3 2387 35000 SH DFND 1,2 35000 0 0 Bluebird Bio Inc COM 09609G100 1306 57435 SH DFND 1,2 57435 0 0 Cell Therapeutics Inc COM NPV NEW 2012 150934883 1360 400000 SH DFND 1,2 400000 0 0 Clovis Oncology Inc COM 189464100 2771 40000 SH DFND 1,2 40000 0 0 Conatus Pharmaceuticals Inc COM 20600T108 651 80000 SH DFND 1,2 80000 0 0 Corcept Therapeutics Inc CALL 218352902 124 1206 SH Call DFND 1,2 1206 0 0 Curis Inc COM 231269101 1237 438800 SH DFND 1,2 438800 0 0 Cytokinetics Inc CALL 23282W905 16 131 SH Call DFND 1,2 131 0 0 Cytokinetics Inc COM NEW 23282W605 1235 130000 SH DFND 1,2 130000 0 0 CytRx Corp COM PAR $.001 232828509 1413 405000 SH DFND 1,2 405000 0 0 Dipexium Pharmaceuticals Inc COM 25456J104 1255 125000 SH DFND 1,2 125000 0 0 Discovery Laboratories Inc COM NEW 254668403 1075 500000 SH DFND 1,2 500000 0 0 Eli Lilly & Co COM 532457108 17658 300000 SH DFND 1,2 300000 0 0 FivePrime Therapeutics Inc COM 33830X104 1769 90000 SH DFND 1,2 90000 0 0 Flexion Therapeutics Inc COM 33938J106 1710 103955 SH DFND 1,2 103955 0 0 Galectin Therapeutics Inc *W EXP 03/28/201 363225111 1225 80000 SH DFND 1,2 80000 0 0 Galmed Pharmaceuticals Ltd SHS M47238106 1950 170000 SH DFND 1,2 170000 0 0 GenVec Inc COM NEW 37246C307 1524 575000 SH DFND 1,2 575000 0 0 Gilead Sciences Inc CALL 375558903 1140 2000 SH Call DFND 1,2 2000 0 0 Gilead Sciences Inc COM 375558103 6661 94000 SH DFND 1,2 94000 0 0 GlaxoSmithKline PLC CALL 37733W905 878 3000 SH Call DFND 1,2 3000 0 0 GlaxoSmithKline PLC SPONSORED ADR 37733W105 34730 650000 SH DFND 1,2 650000 0 0 GlycoMimetics Inc COM 38000Q102 1731 106000 SH DFND 1,2 106000 0 0 Ignyta Inc COM 451731103 1702 205000 SH DFND 1,2 205000 0 0 Immunogen Inc COM 45253H101 515 34500 SH DFND 1,2 34500 0 0 Immunomedics Inc COM 452907108 1263 300000 SH DFND 1,2 300000 0 0 Impax Laboratories Inc CALL 45256B901 335 1000 SH Call DFND 1,2 1000 0 0 Incyte Corp Ltd COM 45337C102 4442 83000 SH DFND 1,2 83000 0 0 Insmed Inc CALL 457669907 355 1000 SH Call DFND 1,2 1000 0 0 Insmed Inc COM PAR $.01 457669307 1333 70000 SH DFND 1,2 70000 0 0 Intra-Cellular Therapies Inc COM 46116X101 1818 100000 SH DFND 1,2 100000 0 0 Ironwood Pharmaceuticals Inc COM CL A 46333X108 1386 112484 SH DFND 1,2 112484 0 0 Johnson & Johnson COM 478160104 21964 223600 SH DFND 1,2 223600 0 0 KaloBios Pharmaceuticals Inc COM 48344T100 976 360000 SH DFND 1,2 360000 0 0 MacroGenics Inc COM 556099109 1141 41000 SH DFND 1,2 41000 0 0 Medivation Inc NOTE 2.625% 4/0 58501NAA9 1609 25000 SH DFND 1,2 25000 0 0 Merck & Co Inc COM 58933Y105 30088 530000 SH DFND 1,2 530000 0 0 Nektar Therapeutics COM 640268108 1212 100000 SH DFND 1,2 100000 0 0 Novartis AG SPONSORED ADR 66987V109 43386 511000 SH DFND 1,2 511000 0 0 NPS Pharmaceuticals Inc COM 62936P103 2335 78000 SH DFND 1,2 78000 0 0 Ocera Therapeutics Inc COM 67552A108 1278 121148 SH DFND 1,2 121148 0 0 Omeros Corp COM 682143102 1207 100000 SH DFND 1,2 100000 0 0 Oncothyreon Inc COM 682324108 2208 738336 SH DFND 1,2 738336 0 0 Peregrine Pharmaceuticals Inc COM NEW 713661304 1216 640000 SH DFND 1,2 640000 0 0 Pfizer Inc CALL 717081903 82 2000 SH Call DFND 1,2 2000 0 0 Pfizer Inc COM 717081103 27450 854596 SH DFND 1,2 854596 0 0 Prothena Corp PLC SHS G72800108 2107 55000 SH DFND 1,2 55000 0 0 QLT Inc COM 746927102 1112 200000 SH DFND 1,2 200000 0 0 Redhill Biopharma Ltd SPONSORED ADS 757468103 2428 1714880 SH DFND 1,2 1714880 0 0 Regado Biosciences Inc COM 75874Q107 2504 200000 SH DFND 1,2 200000 0 0 Relypsa Inc COM 759531106 1410 47300 SH DFND 1,2 47300 0 0 Rexahn Pharmaceuticals Inc COM 761640101 2167 2006200 SH DFND 1,2 2006200 0 0 Sanofi SPONSORED ADR 80105N105 33378 320000 SH DFND 1,2 320000 0 0 Seattle Genetics Inc COM 812578102 5823 127800 SH DFND 1,2 127800 0 0 SPDR S&P Biotech ETF PUT 78464A950 3620 2800 SH Put DFND 1,2 2800 0 0 Summit Corp PLC COM 86606G101 1753 10921656 SH DFND 1,2 10921656 0 0 TetraLogic Pharmaceuticals Cor COM 88165U109 1276 200000 SH DFND 1,2 200000 0 0 Teva Pharmaceutical Industries CALL 881624909 1210 2000 SH Call DFND 1,2 2000 0 0 Teva Pharmaceutical Industries ADR 881624209 1797 34000 SH DFND 1,2 34000 0 0 TG Therapeutics Inc COM 88322Q108 1380 200000 SH DFND 1,2 200000 0 0 Tonix Pharmaceuticals Holding COM NEW 890260201 1041 100000 SH DFND 1,2 100000 0 0 Trevena Inc COM 89532E109 1965 250000 SH DFND 1,2 250000 0 0 uniQure B.V. SHS N90064101 1555 100000 SH DFND 1,2 100000 0 0 United Therapeutics Corp COM 91307C102 4702 50000 SH DFND 1,2 50000 0 0 Vanda Pharmaceuticals Inc COM 921659108 1056 65000 SH DFND 1,2 65000 0 0 Vertex Pharmaceuticals Inc CALL 92532F900 543 500 SH Call DFND 1,2 500 0 0 Vertex Pharmaceuticals Inc COM 92532F100 1414 20000 SH DFND 1,2 20000 0 0 Vical Inc COM 925602104 387 300000 SH DFND 1,2 300000 0 0 Xencor Inc COM 98401F105 1173 100000 SH DFND 1,2 100000 0 0