Partner

0001178913-14-000543.txt : 20140213 0001178913-14-000543.hdr.sgml : 20140213 20140213140358 ACCESSION NUMBER: 0001178913-14-000543 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20131231 FILED AS OF DATE: 20140213 DATE AS OF CHANGE: 20140213 EFFECTIVENESS DATE: 20140213 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 14604963 BUSINESS ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: PLATINUM HOUSE, 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 12-31-2013 12-31-2013 false SPHERA FUNDS MANAGEMENT LTD.

Platinum House, 21 Ha'arba'ah Street Tel Aviv L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received f the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Israel Mor Partner 972-3-6845520 /s/ Israel Mor Tel Aviv L3 02-13-2014 2 96 359010 1 0001599855 Sphera Global Healthcare GP Ltd. 2 0001599854 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ACADIA PHARMACEUTICALS INC COM 4225108 1499 60000 SH DFND 1,2 60000 0 0 ALLERGAN INC CALL 18490902 3332 30000 SH Call DFND 1,2 30000 0 0 AMGEN INC COM 31162100 7991 70000 SH DFND 1,2 70000 0 0 Apple Inc COM 37833100 3097 5520 SH DFND 5520 0 0 ARROWHEAD RESH CORP COM NEW 42797209 217 20000 SH DFND 1,2 20000 0 0 B/E Aerospace Inc COM 73302101 2324 26700 SH DFND 26700 0 0 Broadcom Corp CL A 111320107 2846 96000 SH DFND 96000 0 0 CSX Corp COM 126408103 2110 73325 SH DFND 73325 0 0 Chipotle Mexican Grill Inc COM 169656105 1305 2450 SH DFND 2450 0 0 CLOVIS ONCOLOGY INC COM 189464100 2712 45000 SH DFND 1,2 45000 0 0 COLGATE PALMOLIVE CO COM 194162103 3476 53299 SH DFND 53299 0 0 Copart Inc COM 217204106 2096 57200 SH DFND 57200 0 0 CYTRX CORP COM PAR $.001 232828509 1944 310000 SH DFND 1,2 310000 0 0 DISCOVERY LABORATORIES INC N COM NEW 254668403 1125 500000 SH DFND 1,2 500000 0 0 Foot Locker Inc COM 344849104 2284 55119 SH DFND 55119 0 0 GERON CORP COM 374163103 474 100000 SH DFND 1,2 100000 0 0 GILEAD SCIENCES INC COM 375558103 7064 94000 SH DFND 1,2 94000 0 0 GILEAD SCIENCES INC PUT 375558953 9018 120000 SH Put DFND 1,2 120000 0 0 INSMED INC COM PAR $.01 457669307 799 47000 SH DFND 1,2 47000 0 0 ISHARES MSCI AUST ETF 464287655 7750 67209 SH DFND 67209 0 0 ISHARES MSCI AUST ETF 464288752 2534 102000 SH DFND 102000 0 0 ISIS PHARMACEUTICALS INC COM 464330109 1195 30000 SH DFND 1,2 30000 0 0 JOHNSON & JOHNSON COM 478160104 714 7800 SH DFND 1,2 7800 0 0 JOHNSON & JOHNSON CALL 478160904 32057 350000 SH Call DFND 1,2 350000 0 0 Las Vegas Sands Corp COM 517834107 1946 24677 SH DFND 24677 0 0 MEDICINES CO COM 584688105 1699 44000 SH DFND 1,2 44000 0 0 MERRIMACK PHARMACEUTICALS IN CALL 590328900 533 100000 SH Call DFND 1,2 100000 0 0 NIKE Inc CL B 654106103 1179 14994 SH DFND 14994 0 0 ONCOTHYREON INC COM 682324108 1317 748336 SH DFND 1,2 748336 0 0 PFIZER INC COM 717081103 21517 702496 SH DFND 1,2 702496 0 0 PFIZER INC CALL 717081903 19974 652100 SH Call DFND 1,2 652100 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 1634 63471 SH DFND 1,2 63471 0 0 Precision Castparts Corp COM 740189105 2833 10520 SH DFND 10520 0 0 PRICELINE COM INC COM NEW 741503403 2296 1975 SH DFND 1975 0 0 QLT INC COM 746927102 1114 200000 SH DFND 1,2 200000 0 0 RELYPSA INC COM 759531106 750 30000 SH DFND 1,2 30000 0 0 REXAHN PHARMACEUTICALS INC COM 761640101 765 1500000 SH DFND 1,2 1500000 0 0 RIGEL PHARMACEUTICALS INC COM NEW 766559603 653 229100 SH DFND 1,2 229100 0 0 SAREPTA THERAPEUTICS INC COM 803607100 1630 80000 SH DFND 1,2 80000 0 0 SCHWAB CHARLES CORP NEW COM 808513105 2546 97927 SH DFND 97927 0 0 SEATTLE GENETICS INC COM 812578102 4898 122800 SH DFND 1,2 122800 0 0 Stericycle Inc COM 858912108 3269 28139 SH DFND 28139 0 0 TJX COS INC NEW COM 872540109 4156 65216 SH DFND 65216 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 6012 150000 SH DFND 1,2 150000 0 0 Teva Pharmaceutical Industries CALL 881624909 4008 100000 SH Call DFND 100000 0 0 VANDA PHARMACEUTICALS INC COM 921659108 1179 95000 SH DFND 1,2 95000 0 0 Walgreen Co COM 931422109 2028 35300 SH DFND 35300 0 0 YAHOO INC COM 984332106 1785 44138 SH DFND 44138 0 0 ARQULE INC COM 04269E107 626 291100 SH DFND 1,2 291100 0 0 ACCELERON PHARMA INC COM 00434H108 1980 50000 SH DFND 1,2 50000 0 0 AERIE PHARMACEUTICALS INC COM 00771V108 1976 110000 SH DFND 1,2 110000 0 0 AMBIT BIOSCIENCES CORP COM 02318X100 2256 233995 SH DFND 1,2 233995 0 0 BIOGEN IDEC INC COM 09062X103 3357 12000 SH DFND 1,2 12000 0 0 BLUEBIRD BIO INC COM 09609G100 1939 92435 SH DFND 1,2 92435 0 0 CONATUS PHARMACEUTICALS INC COM 20600T108 565 87600 SH DFND 1,2 87600 0 0 COSTCO WHSL CORP NEW COM 22160K105 3315 27854 SH DFND 27854 0 0 CYTOKINETICS INC COM NEW 23282W605 1086 167000 SH DFND 1,2 167000 0 0 ENANTA PHARMACEUTICALS INC COM 29251M106 690 25292 SH DFND 1,2 25292 0 0 GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 29365 550000 SH DFND 1,2 550000 0 0 INCYTE CORP COM 45337C102 6582 130000 SH DFND 1,2 130000 0 0 INFINITY PHARMACEUTICALS INC COM 45665G303 1381 100000 SH DFND 1,2 100000 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4005 345000 SH DFND 1,2 345000 0 0 KALOBIOS PHARMACEUTICALS INC COM 48344T100 1702 385000 SH DFND 1,2 385000 0 0 MEDIVATION INC COM 58501N101 1915 30000 SH DFND 1,2 30000 0 0 MERCK & CO INC NEW COM 58933Y105 14014 280000 SH DFND 1,2 280000 0 0 MERCK & CO INC NEW CALL 58933Y905 10010 200000 SH Call DFND 1,2 200000 0 0 NPS PHARMACEUTICALS INC COM 62936P103 3886 128000 SH DFND 1,2 128000 0 0 NOVARTIS A G SPONSORED ADR 66987V109 2411 30000 SH DFND 1,2 30000 0 0 OCERA THERAPEUTICS INC COM 67552A108 193 14881 SH DFND 1,2 14881 0 0 ONCOGENEX PHARMACEUTICALS IN COM 68230A106 618 74100 SH DFND 1,2 74100 0 0 ONCONOVA THERAPEUTICS INC COM 68232V108 1378 120000 SH DFND 1,2 120000 0 0 PTC THERAPEUTICS INC COM 69366J200 1249 73583 SH DFND 1,2 73583 0 0 PERNIX THERAPEUTICS HLDGS IN COM 71426V108 142 56500 SH DFND 1,2 56500 0 0 POWERSHARES QQQ TRUST UNIT SER 1 73935A104 7098 80700 SH DFND 80700 0 0 REPROS THERAPEUTICS INC COM NEW 76028H209 2196 120000 SH DFND 1,2 120000 0 0 SEALED AIR CORP NEW COM 81211K100 2384 70000 SH DFND 70000 0 0 SELECT SECTOR SPDR TR SBI MATERIALS 81369Y209 7541 136023 SH DFND 136023 0 0 SELECT SECTOR SPDR TR SBI MATERIALS 81369Y605 16676 762856 SH DFND 762856 0 0 SELECT SECTOR SPDR TR SBI MATERIALS 81369Y704 4945 94623 SH DFND 94623 0 0 SHIRE PLC SPONSORED ADR 82481R106 9184 65000 SH DFND 1,2 65000 0 0 SYNTA PHARMACEUTICALS CORP CALL 87162T906 524 100000 SH Call DFND 1,2 100000 0 0 TARGACEPT INC COM 87611R306 1245 300000 SH DFND 1,2 300000 0 0 TETRALOGIC PHARMACEUTICALS C COM 88165U109 1666 175000 SH DFND 1,2 175000 0 0 THERAVANCE INC COM 88338T104 1016 28500 SH DFND 1,2 28500 0 0 XENCOR INC COM 98401F105 1353 148000 SH DFND 1,2 148000 0 0 XENOPORT INC COM 98411C100 518 90000 SH DFND 1,2 90000 0 0 XOMA CORP DEL COM 98419J107 1077 160000 SH DFND 1,2 160000 0 0 PROTHENA CORP PLC SHS G72800108 1326 50000 SH DFND 1,2 50000 0 0 CHECK POINT SOFTWARE TECH LT ORD M22465104 3571 55353 SH DFND 55353 0 0 ELLOMAY CAPITAL LIMITED SHS M39927120 955 98953 SH DFND 98953 0 0 Orbotech Ltd ORD M75253100 2795 206754 SH DFND 206754 0 0 RADWARE Ltd ORD M81873107 1209 67268 SH DFND 67268 0 0 Silicom Ltd ORD M84116108 1729 37821 SH DFND 37821 0 0 SodaStream International Ltd PUT M9068E955 1986 40000 SH Put DFND 40000 0 0 PROSENSA HLDG N V SHS USD N71546100 899 192428 SH DFND 1,2 192428 0 0 SAPIENS INTL CORP N V SHS NEW N7716A151 793 102798 SH DFND 102798 0 0