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  <element id="clvs_InvestorsTypeDomain" name="InvestorsTypeDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_ExistingInvestorsMember" name="ExistingInvestorsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_PfizerIncorporationMember" name="PfizerIncorporationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_ConvertiblePreferredStockAdditionalTextualAbstract" name="ConvertiblePreferredStockAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedPriorVestingOutstandingNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedPriorVestingOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="clvs_ShareBasedCompensationSharesUnderStockOptionPlansPretaxIntrinsicValueClosingStockPrice" name="ShareBasedCompensationSharesUnderStockOptionPlansPretaxIntrinsicValueClosingStockPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="clvs_PaymentOnTerritoryExpansionMember" name="PaymentOnTerritoryExpansionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_FutureExpectedDevelopmentAndRegulatoryPayment" name="FutureExpectedDevelopmentAndRegulatoryPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="clvs_FairValueAssetsLevelOneAndLevelTwoTransfersAmount" name="FairValueAssetsLevelOneAndLevelTwoTransfersAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="clvs_ConvertiblePromissoryNotesTextualAbstract" name="ConvertiblePromissoryNotesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_ConvertiblePromissoryNotesAdditionalTextualAbstract" name="ConvertiblePromissoryNotesAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_AvailableForSaleSecuritiesTextualAbstract" name="AvailableForSaleSecuritiesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_FinancialInstrumentsAndFairValueMeasurementTextualAbstract" name="FinancialInstrumentsAndFairValueMeasurementTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_ShareBasedCompensationTextualAbstract" name="ShareBasedCompensationTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_ShareBasedCompensationAdditionalTextualAbstract" name="ShareBasedCompensationAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_MaximumIssuableValueOfPreferredStock" name="MaximumIssuableValueOfPreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="clvs_LicenseAgreementsLicensorsNameAxis" name="LicenseAgreementsLicensorsNameAxis" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsLicensorsNameDomain" name="LicenseAgreementsLicensorsNameDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsLicensorClavisPharmaMember" name="LicenseAgreementsLicensorClavisPharmaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsPaymentTypeAxis" name="LicenseAgreementsPaymentTypeAxis" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsPaymentTypeDomain" name="LicenseAgreementsPaymentTypeDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_UpFrontLicensePaymentMember" name="UpFrontLicensePaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementLicenseTermsAxis" name="LicenseAgreementLicenseTermsAxis" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementLicenseTermsDomain" name="LicenseAgreementLicenseTermsDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsLicensorAvilaTherapeuticsMember" name="LicenseAgreementsLicensorAvilaTherapeuticsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_InLicensingArrangementCostsUpFrontPayment" name="InLicensingArrangementCostsUpFrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="clvs_RegulatoryMilestonePaymentMember" name="RegulatoryMilestonePaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_MaximumLicensorDevelopmentCostsReimbursable" name="MaximumLicensorDevelopmentCostsReimbursable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="clvs_LicenseAgreementsLicensorPfizerMember" name="LicenseAgreementsLicensorPfizerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_PrincipalBalanceAndAccruedUnpaidInterest" name="PrincipalBalanceAndAccruedUnpaidInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="clvs_SalesMilestonePaymentsUnderInLicensingAgreements" name="SalesMilestonePaymentsUnderInLicensingAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="clvs_FutureExpectedDevelopmentRegulatoryAndSalesMilestonePayments" name="FutureExpectedDevelopmentRegulatoryAndSalesMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="clvs_BasisOfPresentationPolicyTextBlock" name="BasisOfPresentationPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_NetProceedsFromIssuanceOfCommonStock" name="NetProceedsFromIssuanceOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="clvs_EquityOfferingAbstract" name="EquityOfferingAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_EquityOfferingTextBlock" name="EquityOfferingTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_EquityOfferingTextualAbstract" name="EquityOfferingTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsLicensorAstraZenecaUKLtdMember" name="LicenseAgreementsLicensorAstraZenecaUKLtdMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsKITMember" name="LicenseAgreementsKITMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="clvs_LicenseAgreementsLicensorArrayBioPharmaIncMember" name="LicenseAgreementsLicensorArrayBioPharmaIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
</schema>
