Exhibit 4.2

Mailing Address: Location: PO Box 9431 Stn Prov Govt 2nd Floor—940 Blanshard Street Victoria BC V8W 9V3 Victoria BC www.corporateonline.gov.bc.ca 1 877 526-1526 CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies Notice of Articles BUSINESS CORPORATIONS ACT CAROL PREST This Notice of Articles was issued by the Registrar on: June 23, 2021 09:46 AM Pacific Time Incorporation Number: C1117210 Recognition Date and Time: Continued into British Columbia on May 2, 2017 09:30 AM Pacific Time NOTICE OF ARTICLES Name of Company: ZYMEWORKS INC. REGISTERED OFFICE INFORMATION Mailing Address: Delivery Address: SUITE 2600, THREE BENTALL CENTRE SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 VANCOUVER BC V7X 1L3 CANADA CANADA RECORDS OFFICE INFORMATION Mailing Address: Delivery Address: SUITE 2600, THREE BENTALL CENTRE SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 VANCOUVER BC V7X 1L3 CANADA CANADA

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DIRECTOR INFORMATION Last Name, First Name, Middle Name: Zoth, Lota Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA Last Name, First Name, Middle Name: Renton, Hollings C, Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA Last Name, First Name, Middle Name: Hillan, Kenneth J. Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA Last Name, First Name, Middle Name: Sacks, Natalie Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA Last Name, First Name, Middle Name: Neu, Kelvin Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA Last Name, First Name, Middle Name: Tehrani, Ali Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA

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Last Name, First Name, Middle Name: Cox, Troy Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA Last Name, First Name, Middle Name: Mahony, Susan Mailing Address: Delivery Address: SUITE 540—1385 WEST 8TH AVENUE SUITE 540—1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 VANCOUVER BC V6H 3V9 CANADA CANADA AUTHORIZED SHARE STRUCTURE 1. No Maximum Common Shares Without Par Value With Special Rights or Restrictions attached 2. No Maximum Preferred Shares Without Par Value With Special Rights or Restrictions attached

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