SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Crawford Matthew S (Last) (First) (Middle) 1000 MAIN STREET SUITE 3250 (Street) HOUSTON TX 77002 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 08/09/2006	3. Issuer Name and Ticker or Trading Symbol INSITE VISION INC [ ISV ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	7,744,621	I	By Pinto Technology Ventures, L.P.(1)
Common Stock	128,000	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Common Stock Warrant (right to buy)	11/26/2005	05/26/2010	Common Stock	1,636,364	$0.6325	I	By Pinto Technology Ventures, L.P.(1)
Common Stock Warrant (right to buy)	01/11/2006	01/11/2011	Common Stock	400,000	$0.82	I	By Pinto Technology Ventures, L.P.(1)
Common Stock Warrant (right to buy)	08/14/2006	08/14/2011	Common Stock	458,015	$1.51	I	By Pinto Technology Ventures, L.P.(1)

Explanation of Responses:

1. These shares are held by Pinto Technology Ventures, L.P. ("Pinto LP"). Pinto TV GP Company LLC ("Pinto LLC") is the sole general partner of Pinto Technology Ventures GP, L.P. ("Pinto GP"), which serves as the sole general partner of Pinto LP. Matthew S. Crawford and Evan S. Melrose are managers of Pinto LLC. The Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of his pecuniary interest therein, or any shares held in his name

	/s/ Matthew S. Crawford	08/21/2006
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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