SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Thomas, McNerney & Partners II L.P. (Last) (First) (Middle) 60 SOUTH SIXTH STREET, SUITE 3620 (Street) MINNEAPOLIS MN 55402 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol Auspex Pharmaceuticals, Inc. [ ASPX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 05/14/2014
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	05/14/2014		X		65,839(1)	A	$3.879	5,232,624(2)	I	see footnote(3)
Common Stock	05/14/2014		S(4)		12,400(5)	D	$20.598	5,220,224(6)	I	see footnote(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Common Stock Warrant	$3.879	05/14/2014		X			65,839(1)	(7)	05/22/2014	Common Stock	65,839(1)	$0.00	0	I(3)	see footnote(3)

1. Name and Address of Reporting Person* Thomas, McNerney & Partners II L.P. (Last) (First) (Middle) 60 SOUTH SIXTH STREET, SUITE 3620 (Street) MINNEAPOLIS MN 55402 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* TMP Associates II LP (Last) (First) (Middle) 60 SOUTH SIXTH STREET, SUITE 3620 (Street) MINNEAPOLIS MN 55402 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* TMP Nominee II, LLC (Last) (First) (Middle) 60 SOUTH SIXTH STREET, SUITE 3620 (Street) MINNEAPOLIS MN 55402 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. The securities are held as follows: 64,918 shares by Thomas, McNerney & Partners II, L.P. ("TMP II"), 678 shares by TMP Nominee II, LLC ("TMPN II") and 243 shares by TMP Associates II, L.P. ("TMPA II").

2. Includes 5,159,369 shares held in the name of TMP II; 53,345 shares held in the name of TMPN II; and 19,910 shares held in the name of TMPA II.

3. The securities are held in the name of TMP II, TMPN II and TMPA II. Thomas, McNerney & Partners II, LLC ("TMP II LLC") is the general partner of TMP II and TMPA II.

4. On May 14, 2014, TMP II, TMPN II, and TMPA II exercised warrants to purchase an aggregate 65,839 shares of Auspex Pharmaceuticals, Inc. ("Auspex") common stock for $3.879 per share. The warrants were exercised on a cashless basis, resulting in Auspex withholding 12,400 of the warrant shares to pay the exercise price and issuing a net 53,439 shares of common stock.

5. The securities were disposed of as follows: 12,226 shares by TMP II, 128 shares by TMPN II and 46 shares by TMPA II.

6. Includes 5,147,143 shares held in the name of TMP II; 53,217 shares held in the name of TMPN II; and 19,864 shares held in the name lf TMPA II.

7. The warrant was immediately exercisable.

Remarks:

	Thomas McNerney & Partners II, L.P., By: Thomas McNerney & Partners II, LLC By: /s/ Susan Haedt by power of attorney	09/09/2014
	By Thomas McNerney & Partners II, LLC By: /s/ Susan Haedt by power of attorney	09/09/2014
	By: Alex Zisson, Manager, By: /s/ Susan Haedt by power of attorney	09/09/2014
	** Signature of Reporting Person	Date
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