SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Versant Venture Capital II, LP (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol HELICOS BIOSCIENCES CORP [ HLCS ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 09/18/2009
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	09/18/2009		P		242,931	A	$2.5728(1)	10,709,818(2)	I	Versant Venture Capital II, L.P.

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Warrant to Purchase Common Stock	$2.49	09/18/2009		P		160,821		09/18/2009	03/05/2015	Common Stock	160,821	$0.0828	5,192,770(2)	I	Versant Venture Capital II, L.P.

1. Name and Address of Reporting Person* Versant Venture Capital II, LP (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Samuels Camille D (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* LINK WILLIAM J PHD (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* ROBERTSON REBECCA B (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* JAFFE ROSS A MD (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Bolzon Bradley J PhD (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Warden Charles M (Last) (First) (Middle) 3000 SAND HILL RD., #4-210 (Street) MENLO PARK CA 94025 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. The reported securities are included within units purchased by the Filing Person for $2.57275 per unit. Each unit consists of (i) one share of common stock and (ii) one warrant to purchase 0.662 shares of common stock (representing the closing bid price plus an additional amount for the warrants). Unit were not issued or certificated. The shares of common stock are immediately separable and were issued separately.

2. Each of the Reporting Persons disclaims beneficial ownership of the shares reported, except to the extent of his or her pecuniary interest therein.

Remarks:

Samuel D. Colella, Donald D. Milder and Barbara N. Lubash are also part of this reporting group but are reporting on a separate form due to the limitations on the number of joint filers permitted on one form.

	Robin L. Praeger, Attorney-in-Fact for all Reporting Persons	09/21/2009
	Robin L. Praeger, Attorney-in-Fact for Camille D. Samuels	09/21/2009
	Robin L. Praeger, Attorney-in-Fact for William J. Link, Ph.D.	09/21/2009
	Robin L. Praeger, Attorney-in-Fact for Rebecca B. Robertson	09/21/2009
	Robin L. Praeger, Attorney-in-Fact for Ross A. Jaffe, M.D.	09/21/2009
	Robin L. Praeger, Attorney-in-Fact Bradley J. Bolzon, Ph.D.	09/21/2009
	Robin L. Praeger, Attorney-in-Fact for Charles M. Warden	09/21/2009
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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