SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* AI Loxo Holdings LLC (Last) (First) (Middle) C/O ACCESS INDUSTRIES, INC. 730 FIFTH AVENUE, 20TH FLOOR (Street) NEW YORK NY 10019 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol Loxo Oncology, Inc. [ LOXO ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 08/06/2014
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	08/06/2014		C		1,368,339	A	$0(1)	1,368,339	D(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Convertible Preferred Stock	$0(1)	08/06/2014		C			1,124,999	(1)	(3)	Common Stock	1,124,999	$0(1)	0	D(2)
Series B Convertible Preferred Stock	$0(1)	08/06/2014		C			243,340	(1)	(3)	Common Stock	243,340	$0(1)	0	D(2)

1. Name and Address of Reporting Person* AI Loxo Holdings LLC (Last) (First) (Middle) C/O ACCESS INDUSTRIES, INC. 730 FIFTH AVENUE, 20TH FLOOR (Street) NEW YORK NY 10019 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* AI Value Holdings, LLC (Last) (First) (Middle) C/O ACCESS INDUSTRIES, INC. 730 FIFTH AVENUE, 20TH FL (Street) NEW YORK NY 10019 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* ACCESS INDUSTRIES MANAGEMENT, LLC (Last) (First) (Middle) 730 FIFTH AVENUE (Street) NEW YORK NY 10019 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Blavatnik Len (Last) (First) (Middle) C/O ACCESS INDUSTRIES, INC. 730 FIFTH AVENUE, 20TH FLOOR (Street) NEW YORK NY 10019 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. In connection with the consummation of the Issuer's initial public offering on August 6, 2014, each share of Series A Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into one (1) share of Common Stock for no additional consideration. All shares of Common Stock issued upon conversion were aggregated.

2. The securities reported are directly held by AI Loxo Holdings LLC ("AI Loxo"). AI Value Holdings, LLC ("AI Value") as the sole member of AI Loxo, Access Industries Management, LLC ("Access") as manager of AI Value, and Len Blavatnik as manager of Access, may be deemed to beneficially own the securities held directly by AI Loxo. AI Value, Access and Mr. Blavatnik disclaim beneficial ownership of these securities, except to the extent of its or his pecuniary interest therein, if any, and this Form 3 shall not be construed as an admission that any such reporting person is the beneficial owner of any such securities for purposes of Section 16 or any other purpose.

3. None.

Remarks:

	/s/ Alejandro Moreno for AI Loxo Holdings LLC	08/06/2014
	/s/ Alejandro Moreno for AI Value Holdings, LLC	08/06/2014
	/s/ Alejandro Moreno for Access Industries Management, LLC	08/06/2014
	/s/ Alejandro Moreno for Len Blavatnik	08/06/2014
	** Signature of Reporting Person	Date
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